Abstract：
OBJECTIVES:Clinical disorders occurring in HIV-infected patients on antiretroviral therapy (ART) have been linked to mitochondrial dysfunction, for example, lactic acidosis and lipodystrophy. Mitochondrial membrane potential (delta psi m) is the most direct measure of the state of energization of the mitochondria. We analysed delta psi m, of peripheral blood mononuclear cells (PBMCs) in HIV-negative, healthy subjects (n=8), HIV-infected, treatment-naive patients (n=30), and HIV-infected patients on ART (n=58). The influence of ART was analysed in six patients who started their first regimen. METHODS:The delta psi m of PBMC was measured by flow cytometry using the dye JC-1. RESULTS:The delta psi m was significantly lower in HIV-infected patients than in HIV-negative controls. This difference was detected in both treated (P = 0.0001) and untreated patients (P = 0.001). The delta psi m of PBMCs was highly correlated with CD4+ T-cell count in therapy-naive patients (P = 0.002, r = 0.546) and in treated patients (P = 0.028, r = 0.288). The delta psi m increased significantly in therapy-naive patients after starting ART (P = 0.001). Patients with lipoatrophy had significantly lower delta psi m than patients without lipodystrophy or with lipohypertrophy (P = 0.023). CONCLUSIONS:In HIV-infected persons delta psi m is significantly reduced. Patients with lipoatrophy have significantly reduced delta psi m. This is the first study showing that the delta psi m of PBMCs is highly correlated with CD4+ T-cell count in HIV infection.
journal_name
Antivir Therjournal_title
Antiviral therapyauthors
Sternfeld T,Schmid M,Tischleder A,Mudra S,Schlamp A,Kost BP,Gruber R,Youle M,Bogner JR,Goebel FDsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
769-78issue
5eissn
1359-6535issn
2040-2058journal_volume
12pub_type
临床试验,杂志文章abstract：:Antiretroviral treatment with three nucleoside reverse transcriptase inhibitors (NRTIs) is widely used, but the combination of abacavir, didanosine and stavudine has never been investigated. We describe the surprising and consistent genotypic and phenotypic outcome in patients failing this combination. As part of a Da...
journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Little is known about non-adherence to HBV therapy. This study aimed to investigate the relationship between self-reported missed days of antiviral therapy and HBV virological breakthrough and factors associated with virological breakthrough. METHODS:A cross-sectional survey of 211 HBV patients receiving or...
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pub_type： 杂志文章,多中心研究
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journal_title：Antiviral therapy
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章,多中心研究
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更新日期：2007-01-01 00:00:00
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journal_title：Antiviral therapy
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP3358
更新日期：2020-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP2694
更新日期：2014-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP3281
更新日期：2019-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2010-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP1558
更新日期：2010-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：Antiviral therapy
pub_type： 杂志文章,随机对照试验
doi：
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journal_title：Antiviral therapy
pub_type： 临床试验,杂志文章
doi：
更新日期：2006-01-01 00:00:00
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doi：10.3851/IMP2749
更新日期：2014-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Antiviral therapy
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验,评审
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journal_title：Antiviral therapy
pub_type： 杂志文章
doi：10.3851/IMP3342
更新日期：2019-01-01 00:00:00
