Abstract:
BACKGROUND:Anaemia has been linked with mortality in HIV infection. The mechanism of anaemia in the era of contemporary antiretroviral therapy is not understood. The aim of this study was to describe the association between anaemia and markers of immune activation and inflammation in a cohort of HIV-infected adults on stable antiretroviral therapy. METHODS:We performed a cross-sectional study of HIV-infected adults on antiretroviral therapy with HIV-1 RNA<1,000 copies/ml. Soluble and cellular markers of inflammation and immune activation were measured. Relationships between haemoglobin levels, anaemia (haemoglobin <13 g/dl for men and <12 g/dl for women) and mild anaemia (haemoglobin <14 g/dl for men and <13 g/dl for women) and these markers were explored using multivariable linear regression. RESULTS:Among the 147 participants, median age was 46 years, 78% were men, 68% were African American and 29% were Caucasian. Median body mass index (BMI) was 26.7 kg/m(2), nadir and current CD4(+) T-cell counts were 179 and 613 cells/mm(3), respectively, and 78% had HIV-1 RNA<50 copies/ml (range 20-600 copies/ml). Median (IQR) haemoglobin was 14.3 (13.1-15.1) g/dl; 14% were anaemic and 33% had at least mild anaemia. In multivariable analyses, mild anaemia was independently associated with female sex, older age, shorter duration of antiretroviral therapy, lower white blood cell count, higher platelet count, higher sCD14 and a greater number of CD14(dim)CD16(+) cells or 'patrolling' monocytes, which remained significant after further adjusting for race and BMI. CONCLUSIONS:Having haemoglobin <14 g/dl for men and <13 g/dl for women was independently associated with monocyte activation (sCD14 and CD14(dim)CD16(+) cells) in HIV-infected adults on stable antiretroviral therapy.
journal_name
Antivir Therjournal_title
Antiviral therapyauthors
Lipshultz HM,Hileman CO,Ahuja S,Funderburg NT,McComsey GAdoi
10.3851/IMP2940subject
Has Abstractpub_date
2015-01-01 00:00:00pages
521-7issue
5eissn
1359-6535issn
2040-2058journal_volume
20pub_type
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
pub_type: 杂志文章,多中心研究
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journal_title:Antiviral therapy
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Antiviral therapy
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更新日期:2008-01-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
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更新日期:2005-01-01 00:00:00
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
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pub_type: 杂志文章,多中心研究
doi:10.3851/IMP3188
更新日期:2018-01-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Antiviral therapy
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journal_title:Antiviral therapy
pub_type: 杂志文章,评审
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journal_title:Antiviral therapy
pub_type: 杂志文章
doi:
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journal_title:Antiviral therapy
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更新日期:2017-01-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-08-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 评论,杂志文章
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journal_title:Antiviral therapy
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 杂志文章,多中心研究
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Antiviral therapy
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更新日期:2011-01-01 00:00:00
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journal_title:Antiviral therapy
pub_type: 杂志文章
doi:10.3851/IMP1302
更新日期:2009-01-01 00:00:00