Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations.

abstract：:The linearity of the pharmacokinetics of the metamizol metabolites 4-methyl-amino-antipyrine (4-MAA), 4-amino-antipyrine (4-AA), 4-formyl-aminoantipyrine (4-FAA), and 4-acetyl-amino-antipyrine (4-AcAA) has been studied after administration to 15 healthy male volunteers of single oral doses of 750, 1500, and 3000 mg me...

journal_title：European journal of clinical pharmacology

authors： Vlahov V,Badian M,Verho M,Bacracheva N

更新日期：1990-01-01 00:00:00

abstract：:Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was repl...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Nagai T,Mano T,Arai H,Kodaka R,Matsuoka T,Itagaki Y,Ono J,Okada S

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Intravenous (IV) magnesium sulfate (MgSO4) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. METHODS:To explore the pharmacokinetics (PK) of IV MgSO4 in this population, we collected retrospect...

journal_title：European journal of clinical pharmacology

authors： Rower JE,Liu X,Yu T,Mundorff M,Sherwin CM,Johnson MD

更新日期：2017-03-01 00:00:00

abstract：:We report the first placebo controlled parallel group study of once daily endralazine (5-20 mg) in hypertension uncontrolled by a beta-blocker plus a diuretic. Following a 4-week run-in period 22 patients with a sitting mean arterial pressure (MAP) greater than 110 mm Hg were entered into the study and received either...

journal_title：European journal of clinical pharmacology

authors： McGourty JC,Silas JH,Pidgeon J

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To gain insight into the experiences and handling of adverse drug reactions (ADRs) by the staffs of public primary healthcare (PHC) clinics in Eastern Cape Province, South Africa, as well as their perceptions of related adherence challenges in the treatment and follow-up of human immunodeficiency virus (HIV)-po...

journal_title：European journal of clinical pharmacology

authors： Ruud KW,Srinivas SC,Toverud EL

更新日期：2012-09-01 00:00:00

abstract：:Some physicians regard patients of Geriatric Units as a homogeneous population with respect to digoxin dosage requirements. Others advocate the use of pharmacokinetic models in prescribing digoxin for the elderly. Sixty in-patients of Geriatric Units were studied and the results compared with those previously obtained...

journal_title：European journal of clinical pharmacology

authors： Dobbs RJ,Royston JP,O'Neill CJ,Deshmukh AA,Nicholson PW,Denham MJ,Dobbs SM

更新日期：1987-01-01 00:00:00

abstract：:In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone. The rise in serum insulin levels per...

journal_title：European journal of clinical pharmacology

authors： Mulder H,Schopman W Sr,van der Lely AJ

更新日期：1991-01-01 00:00:00

abstract：:Serotonin (5-HT) stimulates prolactin release. In the present study the ability of dexfenfluramine to increase serum prolactin was used as an index of central 5-HT function after acute and chronic pretreatment of volunteers with fluoxetine. Following a single-blind, random design, on each experimental day each volunte...

journal_title：European journal of clinical pharmacology

authors： Sommers DK,van Wyk M,Snyman JR

更新日期：1994-01-01 00:00:00

abstract：:The kinetics and dynamics of single doses (5 mg p.o.) of the optical isomers of acenocoumarol (R-AC and S-AC) were followed in healthy subjects and the effect on them of cimetidine 800 mg/day was also investigated. The AC enantiomers differed greatly in their pharmacokinetics. The mean residence time (MRT) of R-AC was...

journal_title：European journal of clinical pharmacology

authors： Thijssen HH,Janssen GM,Baars LG

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevale...

journal_title：European journal of clinical pharmacology

authors： van Orten-Luiten AC,Janse A,Dhonukshe-Rutten RA,Witkamp RF

更新日期：2016-05-01 00:00:00

abstract：:The systemic effects of single and multiple doses of inhaled fluticasone propionate (FP) and budesonide were examined in 24 healthy male volunteers (age range 18-29 years). The study was of an open, placebo-controlled, randomized, three-way crossover design. On each study day, multiple blood samples were taken over a ...

journal_title：European journal of clinical pharmacology

authors： Lönnebo A,Grahnén A,Jansson B,Brundin RM,Ling-Andersson A,Eckernäs SA

更新日期：1996-01-01 00:00:00

abstract：:The pharmacokinetics of a new sustained-release preparation of theophylline (Dilatrane à Action Prolongée capsules filled with homogenous microgranules) has been after its studied administration to 7 healthy volunteers at 8 p.m. in order to achieve therapeutic levels at night and in the morning. In separate trials the...

journal_title：European journal of clinical pharmacology

authors： Soubeyrand J,Comet F,Gillet A,Georges D,Brazier JL

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of repaglinide, a novel oral prandial glucose regulator, with that of glibenclamide, an oral hypoglycaemic agent, in the treatment of patients with type 2 diabetes. METHODS:This was a 14-week, double-blind, parallel-group trail in which a total of 195 type 2 diabetic patien...

journal_title：European journal of clinical pharmacology

authors： Landgraf R,Bilo HJ,Müller PG

更新日期：1999-05-01 00:00:00

abstract：:The diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a.m., after a 12 h fast, following randomized administration of Placebo (PL), or Defl...

journal_title：European journal of clinical pharmacology

authors： Pagano G,Lombardi A,Ferraris GM,Imbimbo B,Cavallo Perin P

更新日期：1982-01-01 00:00:00

abstract：:The levels of doxycycline in serum, bile and the gallbladder wall were determined in 25 patients during cholecystectomy, by means of bioassay after previous intravenous administration of doxycycline. The mean biliary level exceeded 20 microgram/ml, and the mean level in the gallbladder wall was greater than 2 microgra...

journal_title：European journal of clinical pharmacology

authors： Moorthi K,Wiederholt K

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:In vitro studies with human liver microsomes have suggested that the oxidative conversion of mexiletine (MX) to its metabolites is catalyzed by CYP2D6 and is significantly impaired in microsomes with the CYP2D6*10/*10 genotype. Therefore, we examined the influence of the CYP2D6*10 allele on MX pharmacokinetic...

journal_title：European journal of clinical pharmacology

authors： Otani M,Fukuda T,Naohara M,Maune H,Senda C,Yamamoto I,Azuma J

更新日期：2003-09-01 00:00:00

abstract：:The effects of sodium nitroprusside (SNP) and 3-morpholino sydnonimine (SIN-1), isosorbide dinitrate (ISDN) and glyceryl trinitrate (GTN), and molsidomine (the inactive precursur of SIN-1) on monocyte chemotaxis and cyclic GMP (cGMP) concentration were studied. SNP and SIN-1 inhibited monocyte N-formyl-methionyl-leucy...

journal_title：European journal of clinical pharmacology

authors： Bath PM

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (...

journal_title：European journal of clinical pharmacology

authors： Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Intragastric pH-metry is widely used to evaluate the efficacy of antisecretory drugs, but statistical interpretation of the measurements has not yet been standardised. METHODS:The effects of single morning (N = 9) or evening (N = 7) doses of the H2-receptor antagonist famotidine, 20 mg (QUAMATELR. Gedeon Ric...

journal_title：European journal of clinical pharmacology

authors： Hunyady B,Juricskay I,Nagy L,Garamszegi M,Vincze A,Mózsik G

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Bosutinib is an oral, dual Src and Abl tyrosine kinase inhibitor (TKI) approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia resistant or intolerant to prior TKI therapy. Bosutinib is primarily metabolized by cytochrome P450 (CYP) 3A4, suggesting drug interaction potential with...

journal_title：European journal of clinical pharmacology

authors： Hsyu PH,Pignataro DS,Matschke K

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

journal_title：European journal of clinical pharmacology

authors： Avontuur JA,Buijk SL,Bruining HA

更新日期：1998-10-01 00:00:00

abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:This study was conducted to examine a complex effect of ciprofibrate therapy in patients with atherogenic lipoprotein phenotype. METHODS:Effects of ciprofibrate were studied on HDL subpopulations, HDL ability to esterify cholesterol (FER(HDL)), susceptibility of LDL to oxidation as well as on in vivo oxidat...

journal_title：European journal of clinical pharmacology

authors： Raslová K,Dobiásová M,Nagyová A,Fábry R,Rauchová H,Dusinská M

更新日期：1998-11-01 00:00:00

abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

journal_title：European journal of clinical pharmacology

authors： Steinijans VW,Diletti E

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetic profiles of transdermal timolol 6 and 24 mg (as 5 and 20% w/v patches) was studied in four healthy young volunteers. To assess its bioavailability, the pharmacokinetics of an IV infusion of timolol maleate 5 mg was also determined in the same subjects. When the 20% (w/v) timolol patch was applied, ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Yamada T,Kikuchi K,Koyama E,Ishizaki T

更新日期：1993-01-01 00:00:00

abstract：:Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP,Forfang K

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The efficacy of beta-adrenergic blocking agents and acetylsalicylic acid in the secondary prevention of myocardial infarction has been well recognized since the beginning of the 1980s. In a previous paper, however, we reported a lower than expected use of these drugs during the period 1982 1988. In 1989 the r...

journal_title：European journal of clinical pharmacology

authors： Martínez M,Agustí A,Arnau JM,Vidal X,Laporte JR

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of the two most common CYP2C9 variant alleles (*2 and *3) on the maintenance dose of warfarin and on the quality of anticoagulation control in Brazilians. METHODS:Patients (n = 103) initiated warfarin therapy with 5 mg/day (or 2.5 mg/day when over 80 years old). The international norma...

journal_title：European journal of clinical pharmacology

authors： Lima MV,Ribeiro GS,Mesquita ET,Victer PR,Vianna-Jorge R

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The study was conducted to investigate whether oral co-administration with citrus juices significantly affects the pharmacokinetics and/or pharmacodynamics of pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy male subjects. Grapefruit juice and orange juice, which were both commercially a...

journal_title：European journal of clinical pharmacology

authors： Hashimoto K,Shirafuji T,Sekino H,Matsuoka O,Sekino H,Onnagawa O,Okamoto T,Kudo S,Azuma J

更新日期：1998-11-01 00:00:00

abstract：:The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers. The steady-state plasma concentration and AUC of indomethacin were significantly increased two- to threefold during treatment with diflunisal and its total clearance and total volume ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Verbesselt R,Tjandra-Maga TB,De Schepper PJ

更新日期：1989-01-01 00:00:00