Abstract:
BACKGROUND:Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age-related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. METHODS:We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-α. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally. RESULTS:Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent. CONCLUSIONS:Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.
journal_name
J Epidemioljournal_title
Journal of epidemiologyauthors
Kheradmand M,Niimura H,Kuwabara K,Nakahata N,Nakamura A,Ogawa S,Mantjoro EM,Shimatani K,Nerome Y,Owaki T,Kusano K,Takezaki Tdoi
10.2188/jea.je20130054subject
Has Abstractpub_date
2013-01-01 00:00:00pages
457-65issue
6eissn
0917-5040issn
1349-9092pii
DN/JST.JSTAGE/jea/JE20130054journal_volume
23pub_type
杂志文章abstract:OBJECTIVE:This study surveyed the sexual behaviour of commercial sex workers and their clients in an attempt to identify factors of transmission of STDs (including HIV/AIDS) and to control their epidemics in Cambodia and South-East Asia. DESIGN:Cross-sectional study. SETTING:Trained questioners asked items of the que...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.9.175
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:The northeast has the lowest incidence of breast cancer of all regions in Thailand, although national rates are increasing. The heterogeneity in subnational trends necessitates a comprehensive evaluation of breast cancer incidence trends and projections to provide evidence for future region-specific strategi...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20170045
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:To clarify the role of physical activity in preventing disability in Japan, we investigated the association between amount of leisure-time physical activity and incidence of disability among the young elderly. METHODS:In the New Integrated Suburban Seniority Investigation (NISSIN) project conducted from 199...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.1016/j.je.2016.11.004
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:In research using accelerometers to measure physical activity, the number of accelerometers that can be utilized in a study and the study duration are both constrained. It means that increasing the number of accelerometer wearing days for all subjects leads to a decrease in the total number of participants t...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20180095
更新日期:2019-11-05 00:00:00
abstract:BACKGROUND:Asian dust events are caused by dust storms that originate in the deserts of China and Mongolia and drift across East Asia. We hypothesized that the dust events would increase incidence of out-of-hospital cardiac arrests by triggering acute events or exacerbating chronic diseases. METHODS:We analyzed the Ut...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20140179
更新日期:2015-01-01 00:00:00
abstract::BackgroundBreaches of ethics undermine the practice of medicine. In Japan, two major scandals involving clinical research and drug marketing occurred after the publication of clinical trials. To study the effects of those scandals, we evaluated changes in the use of first-generation angiotensin II receptor blockers (A...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20200181
更新日期:2020-07-04 00:00:00
abstract:BACKGROUND:Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20150183
更新日期:2016-07-05 00:00:00
abstract:BACKGROUND:Glucose intolerance in patients with amyotrophic lateral sclerosis (ALS) has been inconsistently reported. Evidence for the association of ALS and diabetes mellitus is limited. We aimed to assess the overall and age- and sex-specific risks of ALS among patients with diabetes in Taiwan. METHODS:The study coh...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20140176
更新日期:2015-01-01 00:00:00
abstract::In Japan, the spread of immunization and the development of antibiotics and antituberculosis drugs have dramatically decreased the mortality rate from infectious diseases since World War II. Alterations in health practices, such as decreasing the intake of salty foods and strict management of hypertension, have result...
journal_title:Journal of epidemiology
pub_type: 杂志文章,评审
doi:10.2188/jea.6.3sup_165
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:The adverse effects of maternal smoking on the health of pregnant women have been examined mostly on a disease-by-disease basis. The aims of this study were to evaluate simultaneously the effects of smoking during pregnancy on various obstetric complications, using data from a large medical database, and to ...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20100092
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The life expectancy is an important measure for describing health status among population. Several studies from the United States and Europe showed the harm of smoking by describing the life expectancies with different smoking status. No such study is examined in Japan, the country with the world's highest l...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.17.31
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Large-scale outbreaks of measles occurred in 2013 and 2014 in rural Guangxi, a region in Southwest China with high coverage for measles-containing vaccine (MCV). This study aimed to estimate the timely vaccination coverage, the timely-and-complete vaccination coverage, and the median delay period for MCV amo...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.1016/j.je.2016.08.006
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Health research is not a priority sector in Bangladesh. By and large, physicians and academicians are neither interested nor are they properly trained to conduct quality research. The objective of this study is to quantify the volume of researches related to health in Bangladesh with a view to propose remedi...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.9.235
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Individuals with a self-reported history of sexually transmitted infection (STI) are at high risk for depression. However, little is known about how social support affects the association between STI and depression among young women in Canada. METHODS:Data were drawn from the Canadian Community Health Surve...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20090133
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Urbanizing rural areas in China face a rapidly growing cardiovascular disease burden. Epidemiologic studies and effective preventive strategies are urgently needed. METHODS:The Fangshan Cohort Study is a prospective study that began in 2008 and targets local residents aged 40 years or older living in 3 town...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20120230
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The sentinel surveillance system in Japan provides estimates of nationwide influenza incidence. Although prefectural influenza incidences can be estimated using data from the current surveillance system, such estimates may be imprecise. METHODS:We calculated the numbers of sentinel medical institutions (SMI...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20130077
更新日期:2014-01-01 00:00:00
abstract::BackgroundResearch findings indicate that four health-related behaviours (HRBs), smoking, alcohol, diet, physical activity, do not co-occur within individuals by chance and therefore cluster. To date there is a lack of research investigating the clustering of these HRBs in the Japanese population.MethodsThe Japanese N...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20200120
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:Although birth weight is considered as a fetal determinant of the development of adult-onset diabetes mellitus (DM), its public health importance relative to adult body mass index (BMI) remains unclear. We aimed to examine the association between adult-onset DM and birth weight in relation to adult BMI. MET...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.1016/j.je.2016.08.016
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:We compared the birth weight of newborns born to foreign-born mothers (FBMs) and Taiwan-born mothers (TBMs), using data from the 2005-2006 Taiwan Birth Registry of singleton live births. METHODS:The Wilcox-Russell method, data restriction, and multiple linear regression were used to analyze the data. The ra...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20080096
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Perforated peptic ulcer (PPU) is associated with serious health and economic outcomes. However, few studies have estimated the incidence and health outcomes of PPU using a nationally representative sample in Asia. We estimated age- and sex-specific incidence and short-term mortality from PPU among Koreans an...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20120056
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The different profiles of e-cigarette users in different age groups have seldom been investigated, particularly in populations facing a high prevalence of cigarette smoking. This study aims to examine the prevalence and correlates of e-cigarette use separately for adolescents and adults in nationally represe...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20170300
更新日期:2019-04-05 00:00:00
abstract:BACKGROUND:The effect of active smoking on development of nonalcoholic fatty liver disease (NAFLD) is controversial, and there are limited clinical data on the relationship between passive smoking and NAFLD. We investigated whether active and passive smoking are associated with NAFLD. METHODS:A total of 8580 subjects ...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20120067
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Longitudinal assessment of the impact of tobacco price on smoking cessation is scarce. Our objective was to investigate the effect of a price increase in October 2010 on cessation rates according to gender, age, socioeconomic status, and level of tobacco dependence in Japan. METHODS:We used longitudinal dat...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20140183
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:While laughter is broadly recognized as a good medicine, a potential preventive effect of laughter on disability and death is still being debated. Accordingly, we investigated the association between the frequency of laughter and onset of functional disability and all-cause mortality among the older adults i...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20200051
更新日期:2020-05-16 00:00:00
abstract:BACKGROUND:We surveyed the emergency medical system (EMS) in Taiwan to provide information to policymakers responsible for decisions regarding the redistribution of national medical resources. METHODS:A systematic sampling method was used to randomly sample a representative database from the National Health Insurance ...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20080042
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:While the immunogenicity and effectiveness of seasonal influenza vaccines among subjects with severe motor and intellectual disability (SMID) are known to be diminished, the efficacy of the A/H1N1pdm vaccine has not been evaluated. METHODS:We prospectively evaluated 103 subjects with SMID (mean age, 41.7 ye...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20150036
更新日期:2016-06-05 00:00:00
abstract:BACKGROUND:There have been few prospective studies on diet and glucose abnormalities as determined by oral glucose tolerance test. METHODS:To investigate the impact of dietary factors on the development of glucose intolerance including diabetes and impaired glucose tolerance, we performed a follow-up survey of 1,075 s...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.13.251
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:The association between diabetes and paranasal sinus disease has not been thoroughly investigated. METHODS:We cross-sectionally investigated the association between diabetes and the presence of paranasal sinus disease, which was confirmed by a head MRI scan in 1350 adults who underwent a health screening pr...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.JE20140163
更新日期:2015-01-01 00:00:00
abstract::There are suggestions that women have higher relative risks of lung cancer than men given similar levels of tobacco exposure, implying that sex-related hormones may influence lung cancer risk. We evaluated the association between lung cancer risk and menstrual and reproductive factors on a subset of self-responding fe...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.13.22
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The present study examined the prevalence of diabetes in Japan during the late 1990s and early 2000s using the Japan Public Health Center-based Prospective Diabetes cohort. We also investigated the distributions of HbA1c values in noncompliant diabetic participants in the cohort. METHODS:A total of 28 183 r...
journal_title:Journal of epidemiology
pub_type: 杂志文章
doi:10.2188/jea.je20130196
更新日期:2014-01-01 00:00:00