Does laughter predict onset of functional disability and mortality among older Japanese adults? the JAGES prospective cohort study.

Abstract:

BACKGROUND:While laughter is broadly recognized as a good medicine, a potential preventive effect of laughter on disability and death is still being debated. Accordingly, we investigated the association between the frequency of laughter and onset of functional disability and all-cause mortality among the older adults in Japan. METHODS:The data for a 3-year follow-up cohort including 14,233 individuals (50.3% men) aged ≥ 65 years who could independently perform the activities of daily living and participated in the Japan Gerontological Evaluation Study were analyzed. The participants were classified into four categories according to their frequency of laughter (almost every day, 1-5 days/week, 1-3 days/month, and never or almost never). We estimated the risks of functional disability and all-cause mortality in each category using a Cox proportional hazards model. RESULTS:During follow-up, 605 (4.3%) individuals developed functional disability, identified by new certification for the requirement of Long-Term Care Insurance, and 659 (4.6%) deaths were noted. After adjusting for the potential confounders, the multivariate-adjusted hazard ratio of functional disability increased with a decrease in the frequency of laughter (p for trend = 0.04). The risk of functional disability was 1.42 times higher for individuals who laughed never or almost never than for those who laughed almost every day. No such association was observed with the risk of all-cause mortality (p for trend = 0.39). CONCLUSIONS:Low frequency of laughter is associated with increased risks of functional disability. Laughter may be an early predictor of functional disability later on in life.

journal_name

J Epidemiol

journal_title

Journal of epidemiology

authors

Tamada Y,Takeuchi K,Yamaguchi C,Saito M,Ohira T,Shirai K,Kondo K

doi

10.2188/jea.JE20200051

subject

Has Abstract

pub_date

2020-05-16 00:00:00

eissn

0917-5040

issn

1349-9092

pub_type

杂志文章
  • Research activities of cancer epidemiology in Japan.

    abstract::Cancer epidemiology in Japan has been led by the large-scale population based cohort studies. Permanent registration system has made follow-up easier and more efficient. Low cancer incidence and mortality rates led the researchers to investigate possible preventive factors in diet and life style, in addition to the st...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.2188/jea.6.3sup_19

    authors: Watanabe S,Sobue T,Kinjyo Y

    更新日期:1996-08-01 00:00:00

  • Effectiveness of aquatic exercise and balneotherapy: a summary of systematic reviews based on randomized controlled trials of water immersion therapies.

    abstract:BACKGROUND:The objective of this review was to summarize findings on aquatic exercise and balneotherapy and to assess the quality of systematic reviews based on randomized controlled trials. METHODS:Studies were eligible if they were systematic reviews based on randomized clinical trials (with or without a meta-analys...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.2188/jea.je20090030

    authors: Kamioka H,Tsutani K,Okuizumi H,Mutoh Y,Ohta M,Handa S,Okada S,Kitayuguchi J,Kamada M,Shiozawa N,Honda T

    更新日期:2010-01-01 00:00:00

  • Health related research in Bangladesh: MEDLINE based analysis.

    abstract:BACKGROUND:Health research is not a priority sector in Bangladesh. By and large, physicians and academicians are neither interested nor are they properly trained to conduct quality research. The objective of this study is to quantify the volume of researches related to health in Bangladesh with a view to propose remedi...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.9.235

    authors: Rahman M,Laz TH,Fukui T

    更新日期:1999-08-01 00:00:00

  • It takes a village: Fixed-effects analysis of neighborhood collective efficacy and children's development.

    abstract:BACKGROUND:Previous studies suggest that neighborhood social capital is associated with children's mental health. The purpose of this study was to examine the association between neighborhood collective efficacy and children's psychosocial development. METHODS:We used data on children and their parents (n = 918) who w...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.1016/j.je.2016.08.018

    authors: Ichikawa K,Fujiwara T,Kawachi I

    更新日期:2017-08-01 00:00:00

  • High Tomato and Tomato Product Consumption is Protective Against the Decline in Handgrip Strength Among Japanese Adults: The Oroshisho Study.

    abstract:BACKGROUND:There is scarce epidemiological evidence regarding the relationships of the consumption of different types of vegetables or fruits with change in skeletal muscle strength. We prospectively examined the relationships among Japanese adults, using handgrip strength to assess skeletal muscle strength. METHODS:A...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.JE20170029

    authors: Ren Z,Huang C,Momma H,Cui Y,Niu K,Sugiyama S,Nanno M,Nagatomi R

    更新日期:2018-09-05 00:00:00

  • Reproducibility and validity of dietary patterns assessed by a food frequency questionnaire used in the 5-year follow-up survey of the Japan Public Health Center-Based Prospective Study.

    abstract:BACKGROUND:Analysis of dietary pattern is increasingly popular in nutritional epidemiology. However, few studies have examined the validity and reproducibility of dietary patterns. We assessed the reproducibility and validity of dietary patterns identified by a food frequency questionnaire (FFQ) used in the 5-year foll...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je20110087

    authors: Nanri A,Shimazu T,Ishihara J,Takachi R,Mizoue T,Inoue M,Tsugane S,JPHC FFQ Validation Study Group.

    更新日期:2012-01-01 00:00:00

  • Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake.

    abstract:BACKGROUND:Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes. Since studies considering folate intake are limited, we examined the association between folate intake and serum folate levels, accordi...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je2007417

    authors: Nishio K,Goto Y,Kondo T,Ito S,Ishida Y,Kawai S,Naito M,Wakai K,Hamajima N

    更新日期:2008-01-01 00:00:00

  • Respiratory symptoms and hamsters or other pets: a large-sized population survey in Saitama Prefecture.

    abstract:BACKGROUND:Keeping hamsters as pets has been increasing markedly. Clinical reports have suggested that hamster or other pet ownership is associated with respiratory symptoms. However, this association has not been fully investigated by population-based studies in Japan. The aim of the present study was to investigate t...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.15.9

    authors: Suzuki K,Kayaba K,Tanuma T,Kitazawa J,Yanagawa H

    更新日期:2005-01-01 00:00:00

  • HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.

    abstract:BACKGROUND:We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women. METHODS:A total of 119 patients with invasive cervical squamous cell carcinoma were compared to 119 age- and menopausal...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je20090155

    authors: Hosono S,Kawase T,Matsuo K,Watanabe M,Kajiyama H,Hirose K,Suzuki T,Kidokoro K,Ito H,Nakanishi T,Yatabe Y,Hamajima N,Kikkawa F,Tajima K,Tanaka H

    更新日期:2010-01-01 00:00:00

  • The lack of relationship between an endothelin-1 gene polymorphism (Ala288ser) and incidence of hypertension: a retrospective cohort study among Japanese workers.

    abstract:BACKGROUND:Some case-control association studies revealed the relationship between some endothelin-1 (ET-1) gene polymorphisms and blood pressure. Because no report was available about the relationship between any ET-1 gene polymorphism and incidence of hypertension, we examined the relationship between novel ET-1 gene...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.14.129

    authors: Kaetsu A,Kishimoto T,Osaki Y,Okamoto M,Fukumoto S,Kurozawa Y

    更新日期:2004-07-01 00:00:00

  • Smoking during pregnancy increases risks of various obstetric complications: a case-cohort study of the Japan Perinatal Registry Network database.

    abstract:BACKGROUND:The adverse effects of maternal smoking on the health of pregnant women have been examined mostly on a disease-by-disease basis. The aims of this study were to evaluate simultaneously the effects of smoking during pregnancy on various obstetric complications, using data from a large medical database, and to ...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je20100092

    authors: Hayashi K,Matsuda Y,Kawamichi Y,Shiozaki A,Saito S

    更新日期:2011-01-01 00:00:00

  • Night Work, Rotating Shift Work and the Risk of Cancer in Japanese Men and Women: the JACC Study.

    abstract:BACKGROUND:Limited epidemiological evidence has suggested a positive relationship between night shift work and the risk of cancer. Herein, we investigated the prospective association between different forms of work schedule and the risk of numerous cancers and all-cause cancer among Japanese men and women. METHODS:Thi...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.JE20200208

    authors: Arafa A,Eshak ES,Iso H,Muraki I,Tamakoshi A

    更新日期:2020-08-15 00:00:00

  • Association between nocturnal breastfeeding and snacking habits and the risk of early childhood caries in 18- to 23-month-old Japanese children.

    abstract:BACKGROUND:Early childhood caries (ECC) is one of the most prevalent chronic diseases among children. The aim of this cross-sectional study was to investigate the association between nocturnal breastfeeding, snacking habits, or other risk factors and ECC in 18- to 23-month-old Japanese children. METHODS:Study subjects...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.JE20140097

    authors: Nakayama Y,Mori M

    更新日期:2015-01-01 00:00:00

  • Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method.

    abstract::We examined apolipoprotein E (Apo E) polymorphism and methylenetetrahydrofolate reductase (MTHFR) 677 C to T mutation by using the polymerase chain reaction (PCR) method in 100 elderly Japanese aged 60 or more, and assessed whether these genetic factors are associated with an increased risk for the clinical phenotypes...

    journal_title:Journal of epidemiology

    pub_type: 临床试验,杂志文章

    doi:10.2188/jea.10.163

    authors: Nishiyama M,Kato Y,Hashimoto M,Yukawa S,Omori K

    更新日期:2000-05-01 00:00:00

  • Pathophysiologic mechanisms of obesity and related metabolic disorders: an epidemiologic study using questionnaire and serologic biomarkers.

    abstract:BACKGROUND:It is still unclear whether individuals with the same degree of obesity but different weight histories since young adulthood have different insulin concentration, prevalence of metabolic syndrome components and their clustering. METHODS:A cross-sectional study was conducted on 3,399 (for weight difference a...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.17.141

    authors: Yatsuya H

    更新日期:2007-09-01 00:00:00

  • Health promotion activities in Japan.

    abstract::In Japan, the spread of immunization and the development of antibiotics and antituberculosis drugs have dramatically decreased the mortality rate from infectious diseases since World War II. Alterations in health practices, such as decreasing the intake of salty foods and strict management of hypertension, have result...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.2188/jea.6.3sup_165

    authors: Takeshita T,Morimoto K

    更新日期:1996-08-01 00:00:00

  • Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide: a cross-sectional study in Japan.

    abstract:BACKGROUND:Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. METHODS:...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je20120087

    authors: Suzuki K,Ishii J,Kitagawa F,Kuno A,Kusuhara Y,Ochiai J,Ichino N,Osakabe K,Sugimoto K,Yamada H,Ito Y,Hamajima N,Inoue T

    更新日期:2013-01-01 00:00:00

  • The validity of nursery teachers' report on the physical activity of young children.

    abstract::This study examined the validity of nursery teachers' report on the physical activity of young children. Subjects were twenty-one children aged 3 to 4 years (12 boys and 9 girls) at a nursery in Toyama Prefecture, Japan. Children were equipped with the Actiwatch (Mini-mitter Company Inc.) activity monitor and the Calo...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.12.367

    authors: Chen X,Sekine M,Hamanishi S,Wang H,Hayashikawa Y,Yamagami T,Kagamimori S

    更新日期:2002-09-01 00:00:00

  • Smoking and colorectal cancer in a non-Western population: a prospective cohort study in Japan.

    abstract:BACKGROUND:The risk of colorectal cancer in relation to smoking habits has been examined mostly in Caucasians, and evidence for other ethnic groups is still scarce. METHODS:Our data came from the Japan Collaborative Cohort (JACC) Study. From 1988 through 1990, 25,260 men and 34,619 women aged 40-79 years completed a q...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.13.323

    authors: Wakai K,Hayakawa N,Kojima M,Tamakoshi K,Watanabe Y,Suzuki K,Hashimoto S,Tokudome S,Toyoshima H,Ito Y,Tamakoshi A,JACC Study Group.

    更新日期:2003-11-01 00:00:00

  • The relationship between Asian dust events and out-of-hospital cardiac arrests in Japan.

    abstract:BACKGROUND:Asian dust events are caused by dust storms that originate in the deserts of China and Mongolia and drift across East Asia. We hypothesized that the dust events would increase incidence of out-of-hospital cardiac arrests by triggering acute events or exacerbating chronic diseases. METHODS:We analyzed the Ut...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.JE20140179

    authors: Nakamura T,Hashizume M,Ueda K,Kubo T,Shimizu A,Okamura T,Nishiwaki Y

    更新日期:2015-01-01 00:00:00

  • Relationship of food intake and dietary patterns with blood pressure levels among middle-aged Japanese men.

    abstract::To investigate the relationship of food intake habits and dietary patterns to blood pressure, a cross-sectional study was conducted for 473 middle-aged Japanese males. After adjustment for age, residence, occupation, body mass index and alcohol consumption, mean systolic and diastolic blood pressure (SBP and DBP) were...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.8.106

    authors: Takashima Y,Iwase Y,Yoshida M,Kokaze A,Takagi Y,Taubono Y,Tsugane S,Takahashi T,Iitoi Y,Akabane M,Watanabe S,Akamatsu T

    更新日期:1998-06-01 00:00:00

  • Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study.

    abstract:BACKGROUND:Although birth weight is considered as a fetal determinant of the development of adult-onset diabetes mellitus (DM), its public health importance relative to adult body mass index (BMI) remains unclear. We aimed to examine the association between adult-onset DM and birth weight in relation to adult BMI. MET...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.1016/j.je.2016.08.016

    authors: Katanoda K,Noda M,Goto A,Mizunuma H,Lee JS,Hayashi K

    更新日期:2017-09-01 00:00:00

  • Risk profiles for endometriosis in Japanese women: results from a repeated survey of self-reports.

    abstract:BACKGROUND:The prevalence and risk factors for endometriosis may differ according to diagnosis methodologies, such as study populations and diagnostic accuracy. We examined risk profiles in imaging-diagnosed endometriosis with and without surgical confirmation in a large population of Japanese women, as well as the dif...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.JE20140124

    authors: Yasui T,Hayashi K,Nagai K,Mizunuma H,Kubota T,Lee JS,Suzuki S

    更新日期:2015-01-01 00:00:00

  • Asthma-like disease in the children living in the neighborhood of Mt. Sakurajima.

    abstract::We conducted self-administered questionnaire surveys of school children living in the vicinity of Mt. Sakurajima using ATS-DLD questionnaire. In this paper, we report the results of analysis comparing the proportion of children with asthma-like disease in the area exposed to the volcanic ash and gases released by Mt. ...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.9.27

    authors: Uda H,Akiba S,Hatano H,Shinkura R

    更新日期:1999-02-01 00:00:00

  • The major source of antioxidants intake from typical diet among the rural farmer in north-eastern Japan in 1990s.

    abstract:BACKGROUND:Previous Japanese studies have led to the erroneous conclusion of antioxidant capacity (AOC) intakes of the overall Japanese diet due to limitations in the number and types of food measured, especially in rice and seafood intake. The aims of the study were to construct an AOC database of foods representative...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.JE20190237

    authors: Tsubota-Utsugi M,Watanabe J,Takebayashi J,Oki T,Tsubono Y,Ohkubo T

    更新日期:2020-01-25 00:00:00

  • Descriptive epidemiology of diabetes prevalence and HbA1c distributions based on a self-reported questionnaire and a health checkup in the JPHC diabetes study.

    abstract:BACKGROUND:The present study examined the prevalence of diabetes in Japan during the late 1990s and early 2000s using the Japan Public Health Center-based Prospective Diabetes cohort. We also investigated the distributions of HbA1c values in noncompliant diabetic participants in the cohort. METHODS:A total of 28 183 r...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je20130196

    authors: Kabeya Y,Kato M,Isogawa A,Takahashi Y,Matsushita Y,Goto A,Iso H,Inoue M,Mizoue T,Tsugane S,Kadowaki T,Noda M

    更新日期:2014-01-01 00:00:00

  • Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran Lipid and Glucose Study.

    abstract:OBJECTIVE:To examine the validity and reproducibility of food groups in the semi-quantitative food frequency questionnaire (FFQ) developed for the Tehran Lipid and Glucose Study (TLGS). METHODS:To evaluate the reproducibility of food groups included in the FFQ, 132 subjects (61 men and 71 women) aged 20 years or older...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.je20090083

    authors: Esfahani FH,Asghari G,Mirmiran P,Azizi F

    更新日期:2010-01-01 00:00:00

  • Regional correlation between estimated UVB levels and skin cancer mortality in Japan.

    abstract::Most ecological studies investigating the relationship between incidence and/or mortality of skin cancer and surrogate measures of ultraviolet radiation B (UVB) have been conducted among the Caucasian population. The objective of the present study was therefore to assess the geographical correlation between ambient UV...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.9.6sup_123

    authors: Takahashi K,Pan G,Feng Y,Ohtaki M,Watanabe S,Yamaguchi N

    更新日期:1999-12-01 00:00:00

  • Annual incidence rate of infectious diseases estimated from sentinel surveillance data in Japan.

    abstract:BACKGROUND:The estimation of incidence rates of infectious diseases based on the sentinel surveillance data is rather rare. We attempted to estimate these in 2000 in Japan by the surveillance data, and to evaluate their biases. METHODS:We used the incidences of influenza-like illness and 12 pediatric diseases in each ...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.13.136

    authors: Hashimoto S,Murakami Y,Taniguchi K,Shindo N,Osaka K,Fuchigami H,Nagai M

    更新日期:2003-05-01 00:00:00

  • Differing influence on delays in the case-finding process for tuberculosis between general physicians and specialists in Mongolia.

    abstract::The objective of this study is to compare the influence on delays in the tuberculosis case-finding process according to the types of medical facilities initially visited. The subjects include 107 patients 16 years and older who were diagnosed with bacteriologically confirmed pulmonary tuberculosis at nine tuberculosis...

    journal_title:Journal of epidemiology

    pub_type: 杂志文章

    doi:10.2188/jea.7.93

    authors: Enkhbat S,Toyota M,Yasuda N,Ohara H

    更新日期:1997-06-01 00:00:00