Abstract:
BACKGROUND:We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women. METHODS:A total of 119 patients with invasive cervical squamous cell carcinoma were compared to 119 age- and menopausal status-matched non-cancer controls. Blood samples were taken from all cases and controls and lifestyle information was collected by means of a self-administered questionnaire. The estimated impact of HLA-A alleles on cervical cancer risk was evaluated by unconditional logistic regression models. RESULTS:The frequency of HLA-A(*)0206 among cases was significantly lower than among controls (P = 0.006). There was an inverse association between A(*)0206 and cervical cancer risk (odds ratio [OR] = 0.31, 95% confidence interval [95% CI] = 0.15 to 0.65, P = 0.002), and a positive association for HLA-A(*)2402 (OR = 1.76, 95% CI = 1.00 to 3.09, P = 0.048). After correction for multiple comparisons, A(*)0206 was significantly associated with reduced cervical cancer risk (corrected P = 0.036). Furthermore, the inverse association between A(*)0206 and cervical cancer risk was independent of smoking status (never smoker: OR = 0.37, 95% CI = 0.15 to 0.90; ever smoker: OR = 0.23, 95% CI = 0.06 to 0.89). CONCLUSIONS:There was an inverse association between HLA-A(*)0206 and cervical cancer risk among Japanese women, which suggests that HLA-A polymorphism influences cervical cancer risk. Further investigation in other populations is thus warranted.
journal_name
J Epidemioljournal_title
Journal of epidemiologyauthors
Hosono S,Kawase T,Matsuo K,Watanabe M,Kajiyama H,Hirose K,Suzuki T,Kidokoro K,Ito H,Nakanishi T,Yatabe Y,Hamajima N,Kikkawa F,Tajima K,Tanaka Hdoi
10.2188/jea.je20090155subject
Has Abstractpub_date
2010-01-01 00:00:00pages
295-301issue
4eissn
0917-5040issn
1349-9092pii
JST.JSTAGE/jea/JE20090155journal_volume
20pub_type
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