Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.

abstract：:The effects of in vivo administration of a pharmacologically toxic dose of the lipophilic cationic compound, MKT-077, were investigated in selected vital organs of the rat. MKT-077 (15 mg/kg body weight), administered by bolus i.v. injection every day for 5 days, did not detectably influence rat heart and kidney mitoc...

journal_title：Cancer research

authors： Weisberg EL,Koya K,Modica-Napolitano J,Li Y,Chen LB

更新日期：1996-02-01 00:00:00

abstract：:To assess whether CYP3A4 and CYP3A7 have a similar capacity to activate carcinogenic mycotoxins, we established cell lines stably expressing human CYP3A4 and CYP3A7, which are adult- and fetal-specific forms of cytochrome P450 in human livers, respectively. Each cDNA was introduced into CR-119 cells which had been est...

journal_title：Cancer research

authors： Hashimoto H,Nakagawa T,Yokoi T,Sawada M,Itoh S,Kamataki T

更新日期：1995-02-15 00:00:00

abstract：:Pim serine/threonine kinases contribute to prostate tumorigenesis and therapeutic resistance, yet Pim kinase inhibitors seem to have only limited effects on prostate cancer cell survival. Because overexpression of Bcl-2 family members are implicated in chemotherapeutic resistance in prostate cancer, we investigated th...

journal_title：Cancer research

authors： Song JH,Kraft AS

更新日期：2012-01-01 00:00:00

abstract：:The deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene on chromosome 18q21, encodes a neural cell adhesion molecule family protein that is most highly expressed in the nervous system. To address the hypothesis that DCC may play a role in glioma development and/or progression, we examined DCC ex...

journal_title：Cancer research

authors： Reyes-Mugica M,Rieger-Christ K,Ohgaki H,Ekstrand BC,Helie M,Kleinman G,Yahanda A,Fearon ER,Kleihues P,Reale MA

更新日期：1997-02-01 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:Medulloblastoma is frequently disseminated throughout the central nervous system by the time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality associated with metastatic medulloblastoma and little is known regarding the molecular mechanisms that promote tumor invasion. Previously, w...

journal_title：Cancer research

authors： Hernan R,Fasheh R,Calabrese C,Frank AJ,Maclean KH,Allard D,Barraclough R,Gilbertson RJ

更新日期：2003-01-01 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:Proteolysis-inducing factor (PIF) is a sulfated glycoprotein produced by cachexia-inducing tumors, which induces atrophy of skeletal muscle. PIF has been shown to bind specifically with high affinity (K(d), in nanomolar) to sarcolemma membranes from skeletal muscle of both the mouse and the pig, as well as murine myob...

journal_title：Cancer research

authors： Todorov PT,Wyke SM,Tisdale MJ

更新日期：2007-12-01 00:00:00

abstract：:Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is derived from cancer cells. However, it is not known how much of the circulating DNA is from cancer or from noncancer cells. By quantitative meth...

journal_title：Cancer research

authors： Jahr S,Hentze H,Englisch S,Hardt D,Fackelmayer FO,Hesch RD,Knippers R

更新日期：2001-02-15 00:00:00

abstract：:Glioblastoma multiforme lacks effective therapy options. Although deregulated kinase pathways are drivers of malignant progression in glioblastoma multiforme, glioma cells exhibit intrinsic resistance toward many kinase inhibitors, and the molecular basis of this resistance remains poorly understood. Here, we show tha...

journal_title：Cancer research

authors： Kaur A,Denisova OV,Qiao X,Jumppanen M,Peuhu E,Ahmed SU,Raheem O,Haapasalo H,Eriksson J,Chalmers AJ,Laakkonen P,Westermarck J

更新日期：2016-12-01 00:00:00

abstract：:Dendritic cells (DCs) need activation for the priming of antigen-specific immune responses. Recently activated DCs were described to prime in vitro strong T helper cell type 1 (Th(1)) responses, whereas at later time points, the same cells preferentially prime Th(2) cells [Langenkemp, A. et al., Nat. Immunol. 1: 311-3...

journal_title：Cancer research

authors： Camporeale A,Boni A,Iezzi G,Degl'Innocenti E,Grioni M,Mondino A,Bellone M

更新日期：2003-07-01 00:00:00

abstract：:Antigens in human adult feces related to carcinoembryonic antigen (CEA) were analyzed with respect to their molecular masses, CEA domain compositions, and N-terminal amino acid sequences. By avoiding perchloric acid treatment, new fecal antigens related to CEA were identified. The fecal antigens revealed by Western bl...

journal_title：Cancer research

authors： Henslee JG,Vachula EJ,Paxton RJ,Matias MS,Shively JE,Rittenhouse HG,Tomita JT

更新日期：1992-08-01 00:00:00

abstract：:Levels of epidermal growth factor receptor (EGF-R) and insulin-like growth factor receptor (IGF-R) in breast cancer tissue were evaluated. The binding of growth factors was compared to the content of estrogen receptors (ER) and progesterone receptors (PgR). EGF-R correlated negatively to the ER and PgR (Kendall correl...

journal_title：Cancer research

authors： Pekonen F,Partanen S,Mäkinen T,Rutanen EM

更新日期：1988-03-01 00:00:00

abstract：:Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that develop from other parts of the renal tubular system. To eluci...

journal_title：Cancer research

authors： Polascik TJ,Cairns P,Epstein JI,Fuzesi L,Ro JY,Marshall FF,Sidransky D,Schoenberg M

更新日期：1996-04-15 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:We studied the effects of interleukin-1 alpha (IL-1) and interleukin-6 (IL-6) on MCF-7 breast cancer cells to determine whether these cytokines act additively/synergistically to alter cell growth and metabolism. We found that IL-1 alone (1000 units/ml) inhibited cell growth to a greater degree (83.8%) than IL-6 alone ...

journal_title：Cancer research

authors： Danforth DN Jr,Sgagias MK

更新日期：1993-04-01 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:Capan 1, a human pancreatic cancer cell line, is routinely grown in 10% fetal calf serum (FCS). In order to characterize the factors needed for its proliferation, FCS was replaced by a synthetic serum (Ultroser G). For Capan 1 proliferation we found that Ultroser G was as efficient as FCS. A subfraction of Ultroser G ...

journal_title：Cancer research

authors： Clerc P,Bensaadi N,Pradel P,Estival A,Clemente F,Vaysse N

更新日期：1991-07-15 00:00:00

abstract：:Excess production of the proinflammatory IL6 has both local and systemic tumor-promoting activity in many cancers, including ovarian cancer. However, treatment of advanced ovarian cancer patients with a neutralizing IL6 antibody yielded little efficacy in a previous phase II clinical trial. Here, we report results tha...

journal_title：Cancer research

authors： Milagre CS,Gopinathan G,Everitt G,Thompson RG,Kulbe H,Zhong H,Hollingsworth RE,Grose R,Bowtell DD,Hochhauser D,Balkwill FR

更新日期：2015-04-01 00:00:00

abstract：:The human ether-a-go-go-related gene (herg) encodes a K+ current (IHERG) that plays a fundamental role in heart excitability by regulating the action potential repolarization (IKr); mutations of this gene are responsible for the chromosome 7-linked long QT syndrome (LQT2). In this report, we show that in a variety (n ...

journal_title：Cancer research

authors： Bianchi L,Wible B,Arcangeli A,Taglialatela M,Morra F,Castaldo P,Crociani O,Rosati B,Faravelli L,Olivotto M,Wanke E

更新日期：1998-02-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) expression by human breast cancer has been shown to predict poor patient outcome, as has amplification of the c-erbB-2 proto-oncogene. We have developed a quantitative immunohistochemical method for measuring protein levels of both receptors and have applied this to a series of ...

journal_title：Cancer research

authors： Robertson KW,Reeves JR,Smith G,Keith WN,Ozanne BW,Cooke TG,Stanton PD

更新日期：1996-08-15 00:00:00

abstract：:Molecular markers of pancreatic neoplasia could aid in the evaluation of visible pancreatic lesions and indicate neoplasia invisible to imaging. We evaluated methylation-specific PCR (MSP) assays that detect aberrantly methylated DNA for their use as markers of pancreatic neoplasia. Methylation analysis was done on pa...

journal_title：Cancer research

authors： Matsubayashi H,Canto M,Sato N,Klein A,Abe T,Yamashita K,Yeo CJ,Kalloo A,Hruban R,Goggins M

更新日期：2006-01-15 00:00:00

abstract：:Aluminum sulfonated phthalocyanine has potential as a suitable photosensitizer for use in the photodynamic therapy of cancer. In the present study, cellular uptake and retention of the individual mono-, di-, tri-, and tetrasulfonated derivatives (AlS1-4Pc) were examined in tissue culture and in normal and neoplastic t...

journal_title：Cancer research

authors： Chan WS,Marshall JF,Svensen R,Bedwell J,Hart IR

更新日期：1990-08-01 00:00:00

abstract：:Methyl methanesulfonate (MMS), a direct-acting alkylating agent, is a strong brain carcinogen but a poor hepatocarcinogen in rats. To elucidate the mechanism(s) leading to tissue-specific carcinogenesis in response to MMS, we compared the activation of the stress-activated protein kinases (SAPKs), the c-Jun NH2-termin...

journal_title：Cancer research

authors： Suh Y,Kang UG,Kim YS,Kim WH,Park SC,Park JB

更新日期：2000-09-15 00:00:00

abstract：:Sixteen clones (RASK-1 to -16) of murine monoclonal antibodies were raised against ras Mr 21,000 protein (p21). The p21 produced by Escherichia coli with inserted v-Ki-ras genes was used as immunogen. RASK-1 was found to be specific for Ki-ras p21, whereas RASK-2 to -16 reacted with the p21s of Ki-, N-, and Ha-ras gen...

journal_title：Cancer research

authors： Yoshida K,Hamatani K,Koide H,Ikeda H,Nakamura N,Akiyama M,Tsuchiyama H,Nakayama E,Shiku H

更新日期：1988-10-01 00:00:00

abstract：:The frequency of H-ras, K-ras, and N-ras mutations and the presence of high-risk human papillomavirus (HPV 16, 18, and 33) DNA were studied in 75 paraffin-embedded specimens obtained from 68 Japanese patients with a variety of prostate carcinomas by using polymerase chain reaction and DNA hybridization with sequence-s...

journal_title：Cancer research

authors： Anwar K,Nakakuki K,Shiraishi T,Naiki H,Yatani R,Inuzuka M

更新日期：1992-11-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) promotes a multitude of diverse biological processes, including growth arrest of epithelial cells and proliferation of fibroblasts. Although the TGF-beta signaling pathways that promote inhibition of epithelial cell growth are well characterized, less is known about the mecha...

journal_title：Cancer research

authors： Rahimi RA,Andrianifahanana M,Wilkes MC,Edens M,Kottom TJ,Blenis J,Leof EB

更新日期：2009-01-01 00:00:00

abstract：:Immune effector cells integrate signals that define the nature and magnitude of the subsequent response. Experimental measures for immune cell-mediated lysis of tumors or virally infected targets rely on average responses of permeability or apoptotic changes within a population of targets. Here, we examined individual...

journal_title：Cancer research

authors： Buchser WJ,Laskow TC,Pavlik PJ,Lin HM,Lotze MT

更新日期：2012-06-15 00:00:00

abstract：:The semisynthetic anthracycline, 5-iminodaunorubicin (IM), was investigated to see whether modification of the benzoquinone moiety to produce a drug with low free radical potential would alter the cytotoxic and biochemical characteristics of this drug in comparison to Adriamycin (ADR), an agent with high free radical ...

journal_title：Cancer research

authors： Glazer RI,Hartman KD,Richardson CL

更新日期：1982-01-01 00:00:00

abstract：:8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H) -one (mitozolomide) demonstrates curative action against a range of murine tumor model systems. At single doses of between 20 and 40 mg/kg, the latter of which approximates the 10% lethal dose value in mice, the compound elicited cures against the L121...

journal_title：Cancer research

authors： Hickman JA,Stevens MF,Gibson NW,Langdon SP,Fizames C,Lavelle F,Atassi G,Lunt E,Tilson RM

更新日期：1985-07-01 00:00:00