Abstract：
OBJECTIVE:The purpose of this study was to test the hypothesis that polymorphisms in the endothelial PAS domain protein 1 (EPAS1) gene are associated with the susceptibility to high altitude pulmonary edema (HAPE) in Han Chinese. METHODS:This study enrolled 153 HAPE patients (HAPE-p), matched with Han Chinese resistant to HAPE (HAPE-r) and local highland Tibetans from Yushu earthquake construction population in Qinghai where the altitude is more than 3500 m above sea level. The polymorphism of EPAS1 chr2:46441523(hg18) was genotyped by polymerase chain reaction restriction fragment length polymorphism and confirmed by DNA sequencing. RESULTS:The frequencies of EPAS1 chr2:46441523(hg18) polymorphism C allele were significantly higher in the HAPE-p group than in the HAPE-r group (P < .001), but the frequencies of heterozygous C/G were significantly higher in the HAPE-r group than in the HAPE-p group (P < .001). Moreover, the frequencies of the EPAS1 chr2:46441523(hg18) polymorphism G allele were significantly higher in the highland Tibetan group than in the HAPE-p and HAPE-r groups. CONCLUSIONS:The EPAS1 chr2:46441523(hg18) polymorphism C is strongly associated with susceptibility to HAPE in Han Chinese, and the EPAS1 chr2:46441523(hg18) polymorphism G is present at high frequency and may be associated with high altitude adaptation in the Tibetans.
journal_name
Wilderness Environ Medjournal_title
Wilderness & environmental medicineauthors
Yang YZ,Wang YP,Qi YJ,Du Y,Ma L,Ga Q,Ge RLdoi
10.1016/j.wem.2013.05.006subject
Has Abstractpub_date
2013-12-01 00:00:00pages
315-20issue
4eissn
1080-6032issn
1545-1534pii
S1080-6032(13)00150-6journal_volume
24pub_type
杂志文章abstract：:The ability to control water-borne diseases is critical for soldiers, hikers, and others who may need to drink directly from an outdoor source. Water-borne protozoan parasites that are specifically of concern are Giardia and Cryptosporidium because of their resistance to halogen disinfection. The purpose of this study...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1580/1080-6032(1997)008[0096:eoiwpt]2.3.co;2
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abstract：:We present 3 cases of severe hyponatremia occurring on a commercially guided river rafting trip on the Colorado River in Grand Canyon National Park. All 3 women appeared to have been overhydrating because of concern about dehydration and required evacuation within 24 hours of each other after the staggered onset of sy...
journal_title：Wilderness & environmental medicine
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journal_title：Wilderness & environmental medicine
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更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:The presence of coliform bacteria indicates a watershed risk for harboring microbes capable of causing human disease. We hypothesized that water from watersheds that have different human- or animal-use patterns would have differing risks for the presence of coliform bacteria. METHODS; Water was collected in w...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1580/pr05-05.1
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
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abstract：:Despite the presence of a number of anecdotal reports in the mountaineering literature, mucociliary dysfunction at high altitude has received little scientific attention. However, the dry, cold, thin air at high altitude has the potential to undermine normal mucociliary function. This seems increasingly likely in moun...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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abstract：OBJECTIVE:Portable electronic devices play an important role in the management of type 1 diabetes mellitus. Electromagnetic interference from electronic devices has been shown to impair the function of an avalanche transceiver in search mode (but not in transmitting mode). This study investigates the influence of elect...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2014.12.016
更新日期：2015-06-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2007-07-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2015.11.013
更新日期：2016-03-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2018.02.008
更新日期：2018-09-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.wem.2015.10.008
更新日期：2016-03-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2013.08.002
更新日期：2013-12-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2019.09.004
更新日期：2020-03-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1580/06-weme-or-013r.1
更新日期：2007-04-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2010.10.007
更新日期：2011-03-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1580/07-WEME-OR-092R1.1
更新日期：2007-01-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.wem.2014.11.006
更新日期：2015-06-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1580/1080-6032(1995)006[0220:pepaha]2.3.co;2
更新日期：1995-05-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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更新日期：2004-07-01 00:00:00
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journal_title：Wilderness & environmental medicine
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更新日期：2003-10-01 00:00:00
abstract：:Stingray envenomation is a common occurrence. X-ray evaluation of stingray wounds is an unnecessarily misunderstood diagnostic concept. We present the case of a patient stung by a stingray with a prolonged and complicated course and permanent disability due to a retained barb. The patient had undergone multiple medica...
journal_title：Wilderness & environmental medicine
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更新日期：2015-09-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2010.07.001
更新日期：2010-12-01 00:00:00
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journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:There are 3 pit viper species in Canada. Limited Canadian literature exists on the epidemiology of venomous snakebites and the treatment patterns with antivenom. This study described the epidemiology, the utilization of antivenom, and estimated expenditures due to forfeited antivenom for pit viper envenoma...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2018.06.005
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:We aimed to ascertain risk factors for acute mountain sickness (AMS) in miners exposed to chronic intermittent high altitude conditions. METHODS:All new hires (2009-2012) for mine employment (4000 m above sea level) were followed up for 12 months after first ascent. Demographics, physiologic data, and cigare...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION:Most recreational whitewater fatalities are caused by fixed underwater entrapment or by "flush drowning," an obscure term frequently associated with high-volume rivers, continuous rapids, cold water, and a lack of prolonged underwater entrapment. Although entrapment drowning is typically associated with su...
journal_title：Wilderness & environmental medicine
pub_type： 杂志文章
doi：10.1016/j.wem.2019.09.006
更新日期：2020-03-01 00:00:00
