Abstract:
:Depression and anxiety disorders are common clinical problems in organ transplant recipients, but there is a paucity of clinical data to inform the selection of psychopharmacologic treatment. The authors retrospectively compared 13 depressed organ transplant recipients treated with fluoxetine with 13 nondepressed matched control recipients and 11 transplant recipients treated with tricyclic antidepressants (nortriptyline or desipramine). Blood level:dose ratios and dose-response relationships for cyclosporine were virtually identical in all three groups before and during treatment. No increase in adverse clinical events was detected in either active treatment group compared with the control subjects. Fluoxetine appeared to be well tolerated by this population of transplant patients, and the authors failed to detect significant alterations in cyclosporine levels or graft function.
journal_name
Psychosomaticsjournal_title
Psychosomaticsauthors
Strouse TB,Fairbanks LA,Skotzko CE,Fawzy FIdoi
10.1016/S0033-3182(96)71594-3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
23-30issue
1eissn
0033-3182issn
1545-7206pii
S0033-3182(96)71594-3journal_volume
37pub_type
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