Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorogenic hyperprolactinemia.


BACKGROUND:Antipsychotic drugs have many side effects, including elevation of prolactin levels through tuberoinfundibular dopamine-receptor blockade. Although a number of studies claim that aripiprazole is a prolactin-sparing antipsychotic drug that may even lower prolactin levels, there has not been an exhaustive evaluation of this claim. OBJECTIVE:The authors analyzed the burgeoning literature suggesting that aripiprazole is efficacious in treating iatrogenic and tumorogenic hyperprolactinemia. METHOD:The authors conducted a literature search for case studies, reports, and placebo-controlled trials that measured prolactin levels in adult patients taking aripiprazole. RESULTS:The search identified 17 studies, in which 3,489 psychotic patients were given aripiprazole alone, as an adjuvant to haloperidol or risperidone, or to treat psychosis with a concomitant prolactinoma. Across all studies, aripiprazole lowered prolactin levels an average of 74.3%, even in psychotic patients with prolactinoma, whereas haloperidol and risperidone increased prolactin levels by as much as 272%. CONCLUSION:These findings suggest that aripiprazole may play an important niche role in treating psychotic patients sensitive to elevated prolactin and patients with prolactin-secreting pituitary tumors.






Hoffer ZS,Roth RL,Mathews M




Has Abstract


2009-07-01 00:00:00














  • Are doctors who have been ill more compassionate? Attitudes of resident physicians regarding personal health issues and the expression of compassion in clinical care.

    abstract:BACKGROUND:Compassion is an attribute central to professionalism and modern clinical care, yet little is known about how compassion is acquired and preserved in medical training. We sought to understand whether personal illness experiences are thought by residents to foster compassion. METHODS:The authors surveyed 155...


    pub_type: 杂志文章


    authors: Roberts LW,Warner TD,Moutier C,Geppert CM,Green Hammond KA

    更新日期:2011-07-01 00:00:00

  • Symptoms of posttraumatic stress disorder in patients who have had a myocardial infarction.

    abstract::Symptoms of posttraumatic stress disorder (PTSD) and risk factors for recurrent ischemia were evaluated in 65 survivors of a myocardial infarction (MI) at baseline and 6 months afterward. PTSD patients had more uncontrolled cardiovascular risk factors at baseline. Patients with PTSD (N=14) were offered trauma-focused ...


    pub_type: 杂志文章


    authors: Shemesh E,Koren-Michowitz M,Yehuda R,Milo-Cotter O,Murdock E,Vered Z,Shneider BL,Gorman JM,Cotter G

    更新日期:2006-05-01 00:00:00

  • White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls.

    abstract:BACKGROUND:Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression. It has been proposed that carotid atherosclerosis may predispose to WMLs by inducing cerebral hypoperfusion. This hemodynamic effect of carotid atherosclerosis could be important for the formation of ...


    pub_type: 杂志文章


    authors: Devantier TA,Nørgaard BL,Poulsen MK,Garde E,Øvrehus KA,Marwan M,Achenbach S,Dey D,Sørensen LH,Videbech P

    更新日期:2016-07-01 00:00:00

  • Utilization of medical specialists by anxiety disorder patients.

    abstract::The purpose of this study was to determine the utilization of medical specialists by anxiety disorder patients. The setting was a university's clinical outpatient drug trails for anxiety disorders. The participants were subjects identified by advertisement and diagnosed by psychiatric interviews and, in some instances...


    pub_type: 杂志文章


    authors: Kennedy BL,Schwab JJ

    更新日期:1997-03-01 00:00:00

  • Recurring episodes of Bell's mania after cerebrovascular accident.

    abstract:BACKGROUND:Bell's mania (mania with delirium) is an acute neurobehavioral syndrome of unknown etiology that is characterized by the rapid onset of grandiosity, psychomotor excitement, emotional lability, psychosis, and sleep disruption consistent with mania, coupled with alterations in sensorium, and disorientation cha...


    pub_type: 杂志文章


    authors: Bobo WV,Murphy MJ,Heckers SH

    更新日期:2009-05-01 00:00:00

  • Proactive psychiatric consultation services reduce length of stay for admissions to an inpatient medical team.

    abstract:BACKGROUND:Some studies suggest intensive psychiatric consultation services facilitate medical care and reduce length of stay (LOS) in general hospitals. OBJECTIVE:To compare LOS between a consultation-as-usual model and a proactive consultation model involving review of all admissions, rapid consultation, and close f...


    pub_type: 临床试验,杂志文章


    authors: Desan PH,Zimbrean PC,Weinstein AJ,Bozzo JE,Sledge WH

    更新日期:2011-11-01 00:00:00

  • A curriculum in clinical sexuality for arthritis health care professionals.

    abstract::The results of an experimental training program in sexologic interviewing for a multidisciplinary arthritis patient care team are reported. The program included didactic instruction, observation and practice of interviewing skills, a seminar, and a case presentation. Trainees had gained more knowledge than control sub...


    pub_type: 杂志文章


    authors: Blake DJ,Weaver W,Maisiak R,Alarcon GS,Brown S

    更新日期:1990-04-01 00:00:00

  • Psychoneuroendocrine aspects of temporolimbic epilepsy. Part I. Brain, reproductive steroids, and emotions.

    abstract::The temporolimbic structures of the brain that subserve emotional representation are highly epileptogenic and play an important role in the modulation of hormonal secretion and mediation of hormonal feedback. Estrogen is highly epileptogenic and exerts energizing and antidepressant effects. Excessive estrogen influenc...


    pub_type: 杂志文章,评审


    authors: Herzog AG

    更新日期:1999-03-01 00:00:00

  • Sexual abuse in patients with anorexia nervosa and bulimia.

    abstract::Few studies have documented the extent and nature of sexual abuse among women who later come to treatment for anorexia nervosa or bulimia. This comparison study reports on a sample of 158 patients admitted to an eating-disorder unit, of whom 60 gave a history of sexual abuse, compared to 98 with no history of abuse. F...


    pub_type: 杂志文章


    authors: Hall RC,Tice L,Beresford TP,Wooley B,Hall AK

    更新日期:1989-01-01 00:00:00

  • Relationship of self-perceptions of memory and worry to objective measures of memory and cognition in the general population.

    abstract::This investigation compared how perceived memory ability or level of worry about memory related to performance on objective tests of memory and cognition. Data from 1,488 participants from the Baltimore cohort of the Epidemiologic Catchment Area study were analyzed. Significant associations were found between self-rat...


    pub_type: 杂志文章


    authors: Podewils LJ,McLay RN,Rebok GW,Lyketsos CG

    更新日期:2003-11-01 00:00:00

  • Somatization in primary care. Prevalence, health care utilization, and general practitioner recognition.

    abstract::To study the prevalence of somatoform disorders (SDs) in primary care, a questionnaire including the modified 25-item version of the Symptom Checklist-90 was administered to 191 patients consecutively consulting their family physician. A stratified sample of the patients was interviewed with the Schedules for Clinical...


    pub_type: 杂志文章


    authors: Fink P,Sørensen L,Engberg M,Holm M,Munk-Jørgensen P

    更新日期:1999-07-01 00:00:00

  • Psychiatric aspects of the eosinophilia-myalgia syndrome.

    abstract::The eosinophilia-myalgia syndrome (EMS) is a rare systemic disease caused by presumably contaminated L-tryptophan. Thirteen outpatients with EMS were found to have a high degree of depression, anxiety, and difficulty adjusting to illness. Pre-EMS history of major depression but not EMS severity predicted poor adjustme...


    pub_type: 杂志文章


    authors: Epstein SA,Krahn L,Clauw DJ,Gomes AP,Weigert S,Goldberg RL

    更新日期:1995-01-01 00:00:00

  • Pseudoseizures, families, and unspeakable dilemmas.

    abstract::Fourteen videotaped family interviews of patients with diagnosed pseudoseizures were studied to determine the relationship of the symptoms to unspeakable dilemmas as forced choices imposed by family or social circumstances under conditions that also require the ensuing distress to be hidden. An unspeakable dilemma was...


    pub_type: 杂志文章


    authors: Griffith JL,Polles A,Griffith ME

    更新日期:1998-03-01 00:00:00

  • Preoperative and perioperative predictors of reactive and persistent depression after cardiac surgery: a three-month follow-up study.

    abstract:BACKGROUND:Depression is commonly reported in patients after cardiac surgery and increases the risk of postoperative cardiac morbidity or mortality or both. Although preoperative depression has been implicated as the strongest predictor of depression after surgery, the characteristics thought to influence reactive or p...


    pub_type: 杂志文章


    authors: Patron E,Messerotti Benvenuti S,Palomba D

    更新日期:2014-05-01 00:00:00

  • COMPRI--an instrument to detect patients with complex care needs: results from a European study.

    abstract::The authors developed a screening instrument to detect patients in need of complex care coordination at admission to a general hospital. On the basis of a series of risk factors for care complexity, the authors constructed a short, care complexity prediction instrument (COMPRI) and assessed its qualities. The COMPRI i...


    pub_type: 杂志文章


    authors: Huyse FJ,de Jonge P,Slaets JP,Herzog T,Lobo A,Lyons JS,Opmeer BC,Stein B,Arolt V,Balogh N,Cardoso G,Fink P,Rigatelli M

    更新日期:2001-05-01 00:00:00

  • Typical patterns in atypical anorexia nervosa.

    abstract::Only a few published accounts describe atypical anorexia nervosa. To provide more information about this eating-disorder subtype, 15 patients (12 females, 3 males) with atypical anorexia nervosa were studied. In general, the 12 female patients were characterized by 1) older age at onset and presentation, 2) recurring ...


    pub_type: 杂志文章


    authors: Shisslak CM,Crago M,Yates A

    更新日期:1989-07-01 00:00:00

  • Neuropsychiatric conditions associated with anesthesia exposure.

    abstract:BACKGROUND:Although anesthetics have been used for more than a century, their mechanisms of action remain poorly understood. Given that a number of intraoperative and postoperative neuropsychiatric syndromes have been linked to the use of anesthetics, practitioners should familiarize themselves with these conditions. ...


    pub_type: 杂志文章,评审


    authors: Gross AF,Stern TA

    更新日期:2014-01-01 00:00:00

  • Levels of depressive symptoms in spouses of people with lung cancer: effects of personality, social support, and caregiving burden.

    abstract::The authors sought to identify the personality correlates of depressive symptoms in 120 spouses of people with lung cancer. Spouses completed questionnaires, including measures of personality (neuroticism, extraversion, and interpersonal self-efficacy), social support, and caregiving burden. Their level of depressive ...


    pub_type: 杂志文章


    authors: Kim Y,Duberstein PR,Sörensen S,Larson MR

    更新日期:2005-03-01 00:00:00

  • Somatoform disorders and trauma in medically-admitted children, adolescents, and young adults: prevalence rates and psychosocial characteristics.

    abstract:OBJECTIVE:The purpose of this study is to describe past traumatic experiences in medically-admitted pediatric and young adult patients diagnosed with somatoform disorders and to explore the demographic, diagnostic, and psychosocial differences between those with and without trauma histories. METHODS:Retrospective medi...


    pub_type: 杂志文章


    authors: Thomson K,Randall E,Ibeziako P,Bujoreanu IS

    更新日期:2014-11-01 00:00:00

  • Electroconvulsive therapy in a candidate for heart transplant with an implantable cardiovertor defibrillator and cardiac contractility modulator.

    abstract:BACKGROUND:Electroconvulsive therapy (ECT) can be life-saving in treating depression, even for high-risk cardiac patients. A 56-year-old man with type 2 diabetes and dilated cardiomyopathy, using both a defibrillator and an experimental cardiac contractility modulator, had had episodes of severe depression superimposed...


    pub_type: 杂志文章


    authors: Lynch AM,Pandurangi AK,Levenson JL

    更新日期:2008-07-01 00:00:00

  • Factors associated with disability and depressive symptoms among individuals with diabetes: a community study in Quebec.

    abstract:BACKGROUND:The prevalence of diabetes in Canada is increasing. Multiple factors have been identified in the development of disability in diabetic patients, but the interaction of those risk factors is not clear. OBJECTIVE:The purpose of this paper was to assess the association between diabetes severity, health behavio...


    pub_type: 杂志文章


    authors: Schmitz N,Messier L,Nitka D,Ivanova A,Gariepy G,Wang J,Malla A,Boyer R,Lesage A,Strychar I

    更新日期:2011-03-01 00:00:00

  • Depression and anxiety in ambulatory patients with heart failure.

    abstract:BACKGROUND:Depression and anxiety are common in heart failure, but the prevalence, incidence, and relationship of these conditions to health service use and mortality remains uncertain. OBJECTIVE:The authors sought to delineate these parameters and identify patient factors predicting hospitalizations for heart failure...


    pub_type: 杂志文章


    authors: Cully JA,Johnson M,Moffett ML,Khan M,Deswal A

    更新日期:2009-11-01 00:00:00

  • Beyond capacity: identifying ethical dilemmas underlying capacity evaluation requests.

    abstract:BACKGROUND:Psychiatric consultations involving the evaluation of patients' medical decision-making capacity often seem to have little to do with truly compromised patient autonomy. OBJECTIVE:The authors seek to examine hidden ethical dilemmas that lead to capacity evaluation requests. METHOD:The authors utilize the "...


    pub_type: 杂志文章


    authors: Kontos N,Freudenreich O,Querques J

    更新日期:2013-03-01 00:00:00

  • Adolescent cancer survivors. Psychosocial and familial adaptation.

    abstract::Adolescent cancer survivors were compared with nondiseased control subjects on measures of adaptation, coping, body image, sexual adjustment, psychopathology, and family functioning. Cancer survivors reported no major difficulties in social competence, overall coping, and family communication. Although their school te...


    pub_type: 杂志文章


    authors: Madan-Swain A,Brown RT,Sexson SB,Baldwin K,Pais R,Ragab A

    更新日期:1994-09-01 00:00:00

  • Vertigo "in the pink": The impact of female gender on psychiatric-psychosomatic comorbidity in benign paroxysmal positional vertigo patients.

    abstract:BACKGROUND:Comorbidity between vestibular and psychiatric disorders in predisposed individuals is underestimated, untreated, and may result in chronicization and poor quality of life. There are few studies concerning the type and the prevalence of psychiatric-psychosomatic distress in patients with benign paroxysmal po...


    pub_type: 杂志文章


    authors: Ferrari S,Monzani D,Baraldi S,Simoni E,Prati G,Forghieri M,Rigatelli M,Genovese E,Pingani L

    更新日期:2014-05-01 00:00:00

  • Ready, set, relax: biofeedback-assisted relaxation training (BART) in a pediatric psychiatry consultation service.

    abstract:BACKGROUND:Biofeedback-assisted relaxation training (BART) can treat several common pediatric presentations, including chronic pain and anxiety. Its effectiveness, applicability to a variety of conditions, and equipment portability make it an ideal treatment approach for use in an inpatient pediatric consultation-liais...


    pub_type: 杂志文章


    authors: McKenna K,Gallagher KA,Forbes PW,Ibeziako P

    更新日期:2015-07-01 00:00:00

  • Fluoxetine in pathologic skin-picking: open-label and double-blind results.

    abstract::Various studies suggest that selective serotonin reuptake inhibitors (SSRIs) may be useful in treating pathologic skin-picking. The authors investigated the effectiveness of fluoxetine in treating this behavior. Fifteen subjects with clinically significant skin-picking were recruited by newspaper advertisement. They r...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bloch MR,Elliott M,Thompson H,Koran LM

    更新日期:2001-07-01 00:00:00

  • Depression in Korean immigrants with hepatitis B and related liver diseases.

    abstract::The authors evaluated 50 Korean immigrants who had chronic viral hepatitis or who were healthy carriers for the hepatitis B virus in terms of the relationships between their depression scores, psychosocial stressors, social support, and biological markers of dysfunction. All participants completed a questionnaire, des...


    pub_type: 杂志文章


    authors: Kunkel EJ,Kim JS,Hann HW,Oyesanmi O,Menefee LA,Field HL,Lartey PL,Myers RE

    更新日期:2000-11-01 00:00:00

  • Gender differences in the disability (functional limitations) associated with cardiovascular disease: a general population study.

    abstract:BACKGROUND:Although it is widely believed that women with heart disease have poorer adjustment than men, the term 'adjustment' has typically been narrowly defined as depression. Gender differences in adjustment more broadly defined to encompass functional limitations in addition to depression have seldom been investiga...


    pub_type: 杂志文章


    authors: Scott KM,Collings SC

    更新日期:2012-01-01 00:00:00

  • Psychosocial effects on immune function: neuroendocrine pathways.

    abstract::Psychoneuroimmunology represents the newest interdisciplinary endeavor relevant to psychosomatic medicine. Work in this area is particularly exciting because it promises to reveal a more unified view of the individual and the complex interactions between social, psychological, neural, endocrinological, immunological, ...


    pub_type: 杂志文章,评审


    authors: Daruna JH,Morgan JE

    更新日期:1990-01-01 00:00:00