Abstract：
BACKGROUND:First-episode secondary mania in human immunodeficiency virus (HIV) infection has been described among samples of predominantly Caucasian, HIV-positive male patients in developed countries. OBJECTIVE:The goal of this study was to compare the demographic and clinical characteristics of HIV-positive patients with early-onset and late-onset first-episode secondary mania in HIV infection. There were previous findings of an association between late-onset mania and severe cognitive impairment. METHOD:Subjects were HIV inpatients with clinically-confirmed mania, who received standard demographic, psychiatric, physical, and laboratory assessments. Early-onset patients had CD4 cell counts > 200 mm(3); late-onset patients had CD4 cell counts < or = 200 mm(3). RESULTS:There were no demographic or cognitive differences between early-onset and late-onset mania patients, and high rates of psychotic symptoms in both groups. However, late-onset patients had more manic symptoms. CONCLUSION:Late-onset HIV mania patients had more severe psychopathology and, thus, demonstrated a greater need for highly active retroviral therapy.
journal_name
Psychosomaticsjournal_title
Psychosomaticsauthors
Nakimuli-Mpungu E,Musisi S,Kiwuwa Mpungu S,Katabira Edoi
10.1176/appi.psy.49.6.530subject
Has Abstractpub_date
2008-11-01 00:00:00pages
530-4issue
6eissn
0033-3182issn
1545-7206pii
49/6/530journal_volume
49pub_type
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