Neuroendocrine Disturbances in Neurodegenerative Disorders: A Scoping Review.

Abstract:

BACKGROUND:Neurodegenerative diseases cause progressive irreversible neuronal loss that has broad downstream effects. The neuroendocrine system regulates homeostasis of circuits that control critical functions such as the stress response, metabolism, reproduction, fluid balance, and glucose control. These systems are frequently disrupted in neurodegenerative disorders yet often overlooked in clinical practice. OBJECTIVE:This review aims to gather the available data regarding these disturbances in Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Huntington's disease and also to demonstrate the volume of literature in these individual arenas. METHODS:Using the scoping review framework, a literature search was performed in PubMed to identify relevant articles published within the past 30 years (January 1988 to November 2018). The search criteria produced a total of 2022 articles, 328 of which were identified as relevant to this review. RESULTS:Several major themes emerged from this review. These neuroendocrine disturbances may be a precursor to the illness, a part of the primary pathophysiology, or a direct consequence of the disease or independent of it. They have the potential to further understanding of the disease, exacerbate the underlying pathology, or provide therapeutic benefit. CONCLUSIONS:By synthesizing the data from a systems' perspective, we aim to broaden how clinicians think about these illnesses and provide care.

journal_name

Psychosomatics

journal_title

Psychosomatics

authors

Newhouse A,Chemali Z

doi

10.1016/j.psym.2019.11.002

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

105-115

issue

2

eissn

0033-3182

issn

1545-7206

pii

S0033-3182(19)30223-3

journal_volume

61

pub_type

杂志文章,评审
  • How do delirium and dementia increase length of stay of elderly general medical inpatients?

    abstract::The purpose of this study was to identify the proximate causes through which dementia and delirium extend length of stay (LOS) in elderly general hospital patients. Among 93 patients age >/=65 years admitted to a tertiary-care teaching hospital through the emergency department, admission ratings of cognitive impairmen...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.45.3.235

    authors: Saravay SM,Kaplowitz M,Kurek J,Zeman D,Pollack S,Novik S,Knowlton S,Brendel M,Hoffman L

    更新日期:2004-05-01 00:00:00

  • The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT): a new tool for the psychosocial evaluation of pre-transplant candidates.

    abstract:BACKGROUND:While medical criteria have been well established for each end-organ system, psychosocial listing criteria are less standardized. To address this limitation, we developed and tested a new assessment tool: the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT). METHODS:The SIPAT was deve...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/j.psym.2011.12.012

    authors: Maldonado JR,Dubois HC,David EE,Sher Y,Lolak S,Dyal J,Witten D

    更新日期:2012-03-01 00:00:00

  • Somatization or psychosomatic symptoms?

    abstract::The author describes some problems emerging from the approach to and comprehension of somatization symptoms, discussing ambiguities regarding somatization seen in the current classification manuals (ICD-10 and DSM-IV). Then the author presents a case report of a man who presented with a bizarre symptom of feminization...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.47.2.163

    authors: Avila LA

    更新日期:2006-03-01 00:00:00

  • Alexithymia and life satisfaction in primary healthcare patients.

    abstract::The relationship between life satisfaction and alexithymia was studied in a sample of 229 patients as a part of a naturalistic follow-up study of depression in Finnish primary health care. The measures were the abbreviated Life Satisfaction Scale and the 20-item Toronto Alexithymia Scale. Depression was assessed by te...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.48.6.523

    authors: Mattila AK,Poutanen O,Koivisto AM,Salokangas RK,Joukamaa M

    更新日期:2007-11-01 00:00:00

  • Neuropsychiatric scurvy.

    abstract:BACKGROUND:Scurvy is a disease with well-known peripheral symptoms, such as bleeding and pain. METHODS:The clinical and historical evidence for a distinct form of scurvy affecting the central nervous system, called neuropsychiatric scurvy, is reviewed. Pathophysiologic factors are described, as well as its diagnosis a...

    journal_title:Psychosomatics

    pub_type: 杂志文章,评审

    doi:10.1016/j.psym.2014.05.010

    authors: Brown TM

    更新日期:2015-01-01 00:00:00

  • Change in psychosocial functioning and quality of life of patients with body dysmorphic disorder treated with fluoxetine: a placebo-controlled study.

    abstract::In a 12-week placebo-controlled study of fluoxetine in the treatment of body dysmorphic disorder, the authors investigated change in psychosocial functioning and mental health-related quality of life in 60 subjects. The subjects were assessed with the LIFE-RIFT (a measure of impaired functioning), Social and Occupatio...

    journal_title:Psychosomatics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1176/appi.psy.45.5.438

    authors: Phillips KA,Rasmussen SA

    更新日期:2004-09-01 00:00:00

  • Ready, set, relax: biofeedback-assisted relaxation training (BART) in a pediatric psychiatry consultation service.

    abstract:BACKGROUND:Biofeedback-assisted relaxation training (BART) can treat several common pediatric presentations, including chronic pain and anxiety. Its effectiveness, applicability to a variety of conditions, and equipment portability make it an ideal treatment approach for use in an inpatient pediatric consultation-liais...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/j.psym.2014.06.003

    authors: McKenna K,Gallagher KA,Forbes PW,Ibeziako P

    更新日期:2015-07-01 00:00:00

  • Comparing symptoms of delirium in adults and children.

    abstract::Delirium is presumed to be the same syndrome in all ages. Comparing pediatric and adult studies, the authors found many of the same symptoms reported, but often at significantly different rates. Sleep-wake disturbance, fluctuating symptoms, impaired attention, irritability, agitation, affective lability, and confusion...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.47.4.320

    authors: Turkel SB,Trzepacz PT,Tavaré CJ

    更新日期:2006-07-01 00:00:00

  • Electroconvulsive therapy in a candidate for heart transplant with an implantable cardiovertor defibrillator and cardiac contractility modulator.

    abstract:BACKGROUND:Electroconvulsive therapy (ECT) can be life-saving in treating depression, even for high-risk cardiac patients. A 56-year-old man with type 2 diabetes and dilated cardiomyopathy, using both a defibrillator and an experimental cardiac contractility modulator, had had episodes of severe depression superimposed...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.49.4.341

    authors: Lynch AM,Pandurangi AK,Levenson JL

    更新日期:2008-07-01 00:00:00

  • Congestive heart failure and depression in older adults: clinical course and health services use 6 months after hospitalization.

    abstract::The course of depression and the economic consequences in the 6-month period after hospitalization for congestive heart failure were examined in a prospective observational cohort study involving 203 older adults (mean age=76.8 years, SD=7.8). At discharge, 73 of 203 subjects (36%) were depressed according to the scre...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.44.5.367

    authors: Fulop G,Strain JJ,Stettin G

    更新日期:2003-09-01 00:00:00

  • Adolescent cancer survivors. Psychosocial and familial adaptation.

    abstract::Adolescent cancer survivors were compared with nondiseased control subjects on measures of adaptation, coping, body image, sexual adjustment, psychopathology, and family functioning. Cancer survivors reported no major difficulties in social competence, overall coping, and family communication. Although their school te...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/S0033-3182(94)71739-4

    authors: Madan-Swain A,Brown RT,Sexson SB,Baldwin K,Pais R,Ragab A

    更新日期:1994-09-01 00:00:00

  • A Randomized Double-Blind Controlled Trial Comparing Davanloo Intensive Short-Term Dynamic Psychotherapy as Internet-Delivered Vs Treatment as Usual for Medically Unexplained Pain: A 6-Month Pilot Study.

    abstract:BACKGROUND:Research has shown that Intensive Short-Term Dynamic Psychotherapy (ISTDP) can effectively decrease pain intensity and improve quality of life in patients with medically unexplained pain. OBJECTIVE:Understanding that not all patients with medically unexplained pain have access to in-person ISTDP, this study...

    journal_title:Psychosomatics

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psym.2016.01.001

    authors: Chavooshi B,Mohammadkhani P,Dolatshahi B

    更新日期:2016-05-01 00:00:00

  • The etiology of depression in Parkinson's disease patients.

    abstract::Depression is the major psychiatric complication of Parkinson's disease, and it occurs in approximately one-third of all cases. Diagnosis of depression is complicated by the overlap of depressive and parkinsonian symptoms. Its etiology is not fully understood but involves changes in dopamine and serotonin. Depression ...

    journal_title:Psychosomatics

    pub_type: 杂志文章,评审

    doi:10.1016/S0033-3182(91)72039-2

    authors: Guze BH,Barrio JC

    更新日期:1991-10-01 00:00:00

  • The state of the service: a survey of psychiatry resident education in psychosomatic medicine.

    abstract:BACKGROUND:Although required by the Accreditation Council for Graduate Medical Education, training of general psychiatry residents in Psychosomatic Medicine (PM) varies significantly between programs. In 1996, the Academy of Psychosomatic Medicine (APM) developed guidelines for residency training in PM. Since then, the...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/j.psym.2013.07.005

    authors: Heinrich TW,Schwartz AC,Zimbrean PC,Wright MT,Academy of Psychosomatic Medicine's Residency Education Subcommittee.

    更新日期:2013-11-01 00:00:00

  • Consultants' conflicts: a case discussion of differences and their resolution.

    abstract::Conflicts among consultants are frequent in general hospitals. Unfortunately, such disputes are rarely resolved to the satisfaction of all concerned. The authors discuss the conflicts that may arise among consultants and review techniques that can lead to more effective collaboration. Authors review the literature on ...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.49.1.8

    authors: Caplan JP,Epstein LA,Stern TA

    更新日期:2008-01-01 00:00:00

  • Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial.

    abstract:BACKGROUND:Delirium is a serious postoperative condition for which few pharmacologic prevention trials have been conducted. OBJECTIVE:The authors tested the efficacy of perioperative olanzapine administration to prevent postoperative delirium in elderly patients after joint-replacement surgery. METHOD:The authors con...

    journal_title:Psychosomatics

    pub_type: 杂志文章,随机对照试验

    doi:10.1176/appi.psy.51.5.409

    authors: Larsen KA,Kelly SE,Stern TA,Bode RH Jr,Price LL,Hunter DJ,Gulczynski D,Bierbaum BE,Sweeney GA,Hoikala KA,Cotter JJ,Potter AW

    更新日期:2010-09-01 00:00:00

  • Increased risk of chronic obstructive pulmonary disease in patients with schizophrenia: a population-based study.

    abstract:OBJECTIVE:We investigated the prevalence and incidence of chronic obstructive pulmonary disease (COPD) among patients with schizophrenia in Taiwan. METHODS:From the database provided by the National Health Research Institute, we obtained a random sample of 766,427 subjects aged ≥18 years in 2005. Subjects with a prima...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/j.psym.2012.08.003

    authors: Hsu JH,Chien IC,Lin CH,Chou YJ,Chou P

    更新日期:2013-07-01 00:00:00

  • Personality disorder as a contraindication for liver transplantation in alcoholic cirrhosis.

    abstract::Severe personality disorder has been proposed as a contraindication for liver transplantation. Seventy-three subjects with alcoholic-related liver disease were evaluated for personality disorder and followed for 6 months. The subjects with severe personality disorder had higher rates of divorce, higher rates of comorb...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/S0033-3182(98)71282-4

    authors: Yates WR,LaBrecque DR,Pfab D

    更新日期:1998-11-01 00:00:00

  • Ophthalmologic effects of psychotropic medications.

    abstract::This article reviews the effects of psychotropic medications on the eye. Although some of these effects have been known for years, they have been largely ignored by psychiatrists. The ophthalmologic effects of antidepressants, neuroleptics, benzodiazepines, carbamazepine, and lithium in therapeutic doses and overdose ...

    journal_title:Psychosomatics

    pub_type: 杂志文章,评审

    doi:10.1016/S0033-3182(92)71965-3

    authors: Malone DA Jr,Camara EG,Krug JH Jr

    更新日期:1992-07-01 00:00:00

  • COMPRI--an instrument to detect patients with complex care needs: results from a European study.

    abstract::The authors developed a screening instrument to detect patients in need of complex care coordination at admission to a general hospital. On the basis of a series of risk factors for care complexity, the authors constructed a short, care complexity prediction instrument (COMPRI) and assessed its qualities. The COMPRI i...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.42.3.222

    authors: Huyse FJ,de Jonge P,Slaets JP,Herzog T,Lobo A,Lyons JS,Opmeer BC,Stein B,Arolt V,Balogh N,Cardoso G,Fink P,Rigatelli M

    更新日期:2001-05-01 00:00:00

  • The Millon Behavioral Health Inventory Life Threat Reactivity Scale as a predictor of mortality in patients awaiting heart transplantation.

    abstract::This study examined the Millon Behavioral Health Inventory Life Threat Reactivity Scale (LTRS) as a predictor of mortality in patients awaiting heart transplantation. The one-year mortality while awaiting cardiac transplantation was more than double for the high-risk group based on the LTRS scores. The high-risk group...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/S0033-3182(99)71270-3

    authors: Coffman KL,Brandwin M

    更新日期:1999-01-01 00:00:00

  • Predictors of quality of life in patients with implantable cardioverter defibrillators.

    abstract::Few studies have prospectively examined characteristics of implantable cardioverter defibrillator (ICD) patients as predictors of postimplant outcome. In this study the authors considered the association between preimplant psychological characteristics, ICD shocks, and postimplant quality of life at short- and long-te...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.46.5.451

    authors: Sears SF,Lewis TS,Kuhl EA,Conti JB

    更新日期:2005-09-01 00:00:00

  • Psychometric properties of the 20-item toronto alexithymia scale and prevalence of alexithymia in a finnish adolescent population.

    abstract::The authors assessed, in an adolescent population sample, the internal consistency, test-retest stability, and factor structure of the Toronto Alexithymia Scale (TAS-20) and established the frequency of alexithymia in this age-group. Pupils (N=882; age-groups: 14-, 15-, and 16-year-olds) from two secondary schools com...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.48.2.154

    authors: Säkkinen P,Kaltiala-Heino R,Ranta K,Haataja R,Joukamaa M

    更新日期:2007-03-01 00:00:00

  • Clinical predictors of mental disorders among medical outpatients. Validation of the "S4" model.

    abstract::The authors previously reported four clinical cues that predicted a subgroup of ambulatory patients likely to have depressive and anxiety disorders. The authors' purpose in this study was to validate this model in another cohort of 185 consecutive adult referrals to a rheumatology clinic. The authors found 4 variables...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/S0033-3182(98)71302-7

    authors: Jackson JL,O'Malley PG,Kroenke K

    更新日期:1998-09-01 00:00:00

  • Clinical utility and use of DSM-IV and ICD-10 Criteria and The Memorial Delirium Assessment Scale in establishing a diagnosis of delirium after cardiac surgery.

    abstract::Authors evaluated the sensitivity and specificity of DSM-IV and ICD-10 criteria and the cutoff value of the Memorial Delirium Assessment Scale (MDAS) in diagnosing postoperative delirium in 260 cardiac surgery patients. Incidence of delirium diagnosed on the basis of DSM-IV and ICD-10 criteria, and with the use of the...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.49.1.73

    authors: Kazmierski J,Kowman M,Banach M,Fendler W,Okonski P,Banys A,Jaszewski R,Sobow T,Kloszewska I

    更新日期:2008-01-01 00:00:00

  • Psychoneuroendocrine aspects of temporolimbic epilepsy. Part I. Brain, reproductive steroids, and emotions.

    abstract::The temporolimbic structures of the brain that subserve emotional representation are highly epileptogenic and play an important role in the modulation of hormonal secretion and mediation of hormonal feedback. Estrogen is highly epileptogenic and exerts energizing and antidepressant effects. Excessive estrogen influenc...

    journal_title:Psychosomatics

    pub_type: 杂志文章,评审

    doi:10.1016/S0033-3182(99)71254-5

    authors: Herzog AG

    更新日期:1999-03-01 00:00:00

  • Psychiatric aspects of the eosinophilia-myalgia syndrome.

    abstract::The eosinophilia-myalgia syndrome (EMS) is a rare systemic disease caused by presumably contaminated L-tryptophan. Thirteen outpatients with EMS were found to have a high degree of depression, anxiety, and difficulty adjusting to illness. Pre-EMS history of major depression but not EMS severity predicted poor adjustme...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/s0033-3182(95)71703-0

    authors: Epstein SA,Krahn L,Clauw DJ,Gomes AP,Weigert S,Goldberg RL

    更新日期:1995-01-01 00:00:00

  • Patients with "organically unexplained symptoms" presenting to a borreliosis clinic: clinical and psychobehavioral characteristics and quality of life.

    abstract:OBJECTIVE:This study explores the prevalence of patients with "organically unexplained symptoms" presenting to a Lyme borreliosis clinic and describes their clinical and psychobehavioral characteristics as well as health-related quality of life. METHODS:Study instruments consisted of a set of self-rating questionnaire...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1016/j.psym.2012.08.012

    authors: Csallner G,Hofmann H,Hausteiner-Wiehle C

    更新日期:2013-07-01 00:00:00

  • Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorogenic hyperprolactinemia.

    abstract:BACKGROUND:Antipsychotic drugs have many side effects, including elevation of prolactin levels through tuberoinfundibular dopamine-receptor blockade. Although a number of studies claim that aripiprazole is a prolactin-sparing antipsychotic drug that may even lower prolactin levels, there has not been an exhaustive eval...

    journal_title:Psychosomatics

    pub_type: 杂志文章,评审

    doi:10.1176/appi.psy.50.4.317

    authors: Hoffer ZS,Roth RL,Mathews M

    更新日期:2009-07-01 00:00:00

  • Untreated trichotillomania and trichophagia: surgical emergency in a teenage girl.

    abstract::Trichophagia secondary to trichotillomania can be a potentially life-threatening condition if left untreated. This report documents the unique case of a 16-year-old girl whose untreated trichotillomania led to a trichobezoar requiring surgical intervention and follow-up psychiatric treatment. Challenges in the identif...

    journal_title:Psychosomatics

    pub_type: 杂志文章

    doi:10.1176/appi.psy.46.4.362

    authors: Salaam K,Carr J,Grewal H,Sholevar E,Baron D

    更新日期:2005-07-01 00:00:00