Impact of donor and recipient age difference on long-term allograft survival after living donor renal transplantation: analysis of 478 cases.

Abstract:

INTRODUCTION:Either deceased or living-related renal transplantation constitutes the best therapeutic option for patients with end-stage renal disease. In this retrospective study, an attempt to identify parameters that affect allograft survival in living donor renal transplantation was made. METHODS:Between January 2000 and July 2012, 478 adult patients received a renal transplant from a living-related donor in our center and their records were retrospectively reviewed in November 2012. Data concerning donor age, recipient age, donor/recipient age difference, donor/recipient gender, and ABO compatibility/incompatibility were recorded and associated with renal allograft survival rate. RESULTS:Renal allograft survival rate was 96%, 89.5%, and 77.7% in the first, fifth, and 10th yr after transplantation, respectively. Only the difference between donor and recipient age was statistically significant in relation to graft survival. In cases with age difference >13 yr, graft survival rate was lower from the third yr onward. CONCLUSIONS:Only the age difference between donor and recipient exerts an adverse impact on graft outcome after living donor renal transplantation, whereas donor age, recipient age, donor/recipient gender, and ABO incompatibility do not significantly influence renal allograft survival.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Kostakis ID,Moris DN,Barlas A,Bokos I,Darema M,Theodoropoulou E,Karaolanis G,Kostakis A,Boletis I,Zavos G

doi

10.1111/ctr.12219

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

838-43

issue

6

eissn

0902-0063

issn

1399-0012

journal_volume

27

pub_type

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