Abstract:
:The clinical utility of genotypic drug resistance testing (DRT) in HIV-infected children on antiretroviral therapy (ART) is not well understood. HIV-infected patients aged <19 years undergoing DRT for virological failure were retrospectively enrolled. Indications for DRT and changes in HIV RNA load were recorded. Between January 2000 and December 2006, 57 patients had DRT. The most common indication for DRT was poor ART adherence (57.7% of patients). ART was changed in 50.9% of patients after DRT. Poor adherence was cited by clinicians for not changing ART significantly more often than any other reason (47.3%, P < 0.001). After DRT, significant improvement in HIV RNA load occurred independent of ART changes, though patients whose ART was modified were more likely to become undetectable (31.5% versus 7.0%, P < 0.001). Poor adherence was a significant factor for ordering DRT and for not changing ART in HIV-infected children.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Dehority W,Deville JG,Lujan-Zilbermann J,Spector SA,Viani RMdoi
10.1177/0956462412473958subject
Has Abstractpub_date
2013-07-01 00:00:00pages
549-53issue
7eissn
0956-4624issn
1758-1052pii
0956462412473958journal_volume
24pub_type
杂志文章abstract::This study employed culture and polymerase chain reaction (PCR) to examine the prevalence of Ureaplasma urealyticum, Mycoplasma hominis, Mycoplasma genitalium, Mycoplasma fermentans, Mycoplasma penetrans and Mycoplasma pirum in 210 HIV/AIDS patients, 455 sexually transmitted infection (STI) clinic attendees and 245 he...
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
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