Cloning and sequence analysis of linear plasmid telomeres of the bacterium Borrelia burgdorferi.

abstract：:MreB shares a common prokaryotic ancestor with actin and is present in almost all rod-shaped bacteria. MreB proteins have been implicated in a range of important cell processes, including cell morphogenesis, chromosome segregation and cell polarity. The mreB gene frequently lies at the beginning of a cluster of genes,...

journal_title：Molecular microbiology

authors： Formstone A,Errington J

更新日期：2005-03-01 00:00:00

abstract：:In Escherichia coli, initiation of chromosome replication requires that DnaA binds to R boxes (9-mer repeats) in oriC, the unique chromosomal replication origin. At the time of initiation, integration host factor (IHF) also binds to a specific site in oriC. IHF stimulates open complex formation by DnaA on supercoiled ...

journal_title：Molecular microbiology

authors： Grimwade JE,Ryan VT,Leonard AC

更新日期：2000-02-01 00:00:00

abstract：:Bacteriophages recognize and bind to their hosts with the help of receptor-binding proteins (RBPs) that emanate from the phage particle in the form of fibers or tailspikes. RBPs show a great variability in their shapes, sizes, and location on the particle. Some RBPs are known to depolymerize surface polysaccharides of...

journal_title：Molecular microbiology

authors： Prokhorov NS,Riccio C,Zdorovenko EL,Shneider MM,Browning C,Knirel YA,Leiman PG,Letarov AV

更新日期：2017-08-01 00:00:00

abstract：:Cryptococcus neoformans is a pathogenic yeast that causes life-threatening meningoencephalitis and grows well on mycological media regardless of inoculum size. Interestingly, a deletion of the global repressor TUP1 in C. neoformans uncovered a density-dependent growth phenotype reminiscent of the quorum-sensing phenom...

journal_title：Molecular microbiology

authors： Lee H,Chang YC,Nardone G,Kwon-Chung KJ

更新日期：2007-05-01 00:00:00

abstract：:Chromalveolates like the diatom Phaeodactylum tricornutum arose through the uptake of a red alga by a phagotrophic protist, a process termed secondary endosymbiosis. In consequence, the plastids are surrounded by two additional membranes compared with primary plastids. This plastid morphology poses additional barriers...

journal_title：Molecular microbiology

authors： Hempel F,Felsner G,Maier UG

更新日期：2010-05-01 00:00:00

abstract：:The outer membrane channel TolC is a key component of multidrug efflux and type I secretion transporters in Escherichia coli. Mutational inactivation of TolC renders cells highly susceptible to antibiotics and leads to defects in secretion of protein toxins. Despite impairment of various transport functions, no growth...

journal_title：Molecular microbiology

authors： Dhamdhere G,Zgurskaya HI

更新日期：2010-08-01 00:00:00

abstract：:The flexible pilus of Aeromonas hydrophila is a morphologically and biochemically unique organelle which binds eukaryotic cell surfaces and whose expression is induced by specific physiochemical conditions. fxp, the structural gene coding for the flexible pilus subunit, was localized on a 7.6kb plasmid of A. hydrophil...

journal_title：Molecular microbiology

authors： Ho AS,Sohel I,Schoolnik GK

更新日期：1992-09-01 00:00:00

abstract：:We have identified and characterized three genes, SUT1, SUT2 and SUT3, that encode glucose transporters of the yeast Pichia stipitis. When expressed in a Saccharomyces cerevisiae hxt null mutant strain that is unable to take up monosaccharides, all three proteins restored growth on glucose. Sequencing of the genes rev...

journal_title：Molecular microbiology

authors： Weierstall T,Hollenberg CP,Boles E

更新日期：1999-02-01 00:00:00

abstract：:PrkC was shown to be a eukaryotic-like (Hanks-type) protein kinase from Bacillus subtilis with a structural organization similar to that of the eukaryotic sensor Ser/Thr or Tyr kinases (e.g. the TGF beta or PDGF receptors). The molecule consists of a catalytic domain located in the cytoplasm, joined by a single transm...

journal_title：Molecular microbiology

authors： Madec E,Laszkiewicz A,Iwanicki A,Obuchowski M,Séror S

更新日期：2002-10-01 00:00:00

abstract：:Expression of Escherichia coli hupA and hupB, the structural genes encoding the most abundant nucleoid-associated proteins HUalpha and HUbeta has been studied during cold shock. This article demonstrates that: (i) transcriptional expression of hupA is blocked following a sudden temperature downshift (from 37 degrees C...

journal_title：Molecular microbiology

authors： Giangrossi M,Giuliodori AM,Gualerzi CO,Pon CL

更新日期：2002-04-01 00:00:00

abstract：:Borrelia hermsii, an agent of relapsing fever, avoids the host's immune response by means of multiphasic antigenic variation. Serotype specificity is determined by variable antigens called the Vmp lipoproteins. Through recombination between linear plasmids a formerly silent vmp gene replaces another vmp gene at a telo...

journal_title：Molecular microbiology

authors： Barbour AG,Burman N,Carter CJ,Kitten T,Bergström S

更新日期：1991-02-01 00:00:00

abstract：:The expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer. Owing to end product inhibition of the first ste...

journal_title：Molecular microbiology

authors： Becker B,Feller A,el Alami M,Dubois E,Piérard A

更新日期：1998-07-01 00:00:00

abstract：:The Clostridium difficile toxA and toxB genes, encoding cytotoxic and enterotoxic proteins responsible for antibiotic-associated colitis and pseudomembranous colitis, were shown to be transcribed both from gene-specific promoters and from promoters of upstream genes. However, the gene-specific transcripts represented ...

journal_title：Molecular microbiology

authors： Dupuy B,Sonenshein AL

更新日期：1998-01-01 00:00:00

abstract：:N-glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N-glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid-linked core-oligosaccharide to...

journal_title：Molecular microbiology

authors： Hauptmann P,Riel C,Kunz-Schughart LA,Fröhlich KU,Madeo F,Lehle L

更新日期：2006-02-01 00:00:00

abstract：:We report the identification and functional analysis of katN, a gene encoding a non-haem catalase of Salmonella enterica serotype Typhimurium. katN, which is not present in Escherichia coli, is located between the yciGFE and yciD E. coli homologues in the Salmonella genome. Its predicted protein product has a molecula...

journal_title：Molecular microbiology

authors： Robbe-Saule V,Coynault C,Ibanez-Ruiz M,Hermant D,Norel F

更新日期：2001-03-01 00:00:00

abstract：:The mechanisms of transcription repression and derepression in vivo are not fully understood. We have obtained evidence that begins to clarify the minimum requirements for counteracting nucleosomal repression in vivo. Location of the TATA element near the nucleosome dyad does not block RNA polymerase II transcription ...

journal_title：Molecular microbiology

authors： Moss DR,Laybourn PJ

更新日期：2000-06-01 00:00:00

abstract：:The AbcR small RNAs (sRNAs) are a fascinating example of two highly conserved sRNAs that differ tremendously at the functional level among organisms. From their transcriptional activation to their regulatory capabilities, the AbcR sRNAs exhibit varying characteristics in three well-studied bacteria belonging to the Rh...

journal_title：Molecular microbiology

authors： Sheehan LM,Caswell CC

更新日期：2018-01-01 00:00:00

abstract：:Induction of the sugar-phosphate transport system in Escherichia coli by external glucose-6-phosphate is regulated by the UhpABC regulatory proteins. UhpA protein is required for uhpT transcription and is related to response regulators of two-component regulatory systems. UhpA and its homologues appear to be composed ...

journal_title：Molecular microbiology

authors： Webber CA,Kadner RJ

更新日期：1995-03-01 00:00:00

abstract：:Despite their high genomic synteny, the Leishmania major and Leishmania infantum species exhibit extensive differences in mRNA expression patterns throughout the parasite's development. Yet, the underlying mechanisms for this species-specific differential gene expression are largely unknown. Here we report that Short ...

journal_title：Molecular microbiology

authors： Müller M,Padmanabhan PK,Papadopoulou B

更新日期：2010-07-01 00:00:00

abstract：:Iron is a member of a small group of nutrients that limits aquatic primary production. Mechanisms for utilizing iron have to be efficient and adapted according to the ecological niche. In respect to iron acquisition cyanobacteria, prokaryotic oxygen evolving photosynthetic organisms can be divided into siderophore- an...

journal_title：Molecular microbiology

authors： Rudolf M,Kranzler C,Lis H,Margulis K,Stevanovic M,Keren N,Schleiff E

更新日期：2015-08-01 00:00:00

abstract：:The polA gene of Escherichia coli encodes DNA polymerase I that is involved in DNA replication and repair. Despite the wide knowledge about structure and function of DNA polymerase I, there is little insight into the regulatory mechanisms involved in polA expression. DnaA is the initiator protein for DNA replication i...

journal_title：Molecular microbiology

authors： Quiñones A,Wandt G,Kleinstäuber S,Messer W

更新日期：1997-03-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:Computer analysis of the crystallographic structure of the A subunit of Escherichia coli heat-labile toxin (LT) was used to predict residues involved in NAD binding, catalysis and toxicity. Following site-directed mutagenesis, the mutants obtained could be divided into three groups. The first group contained fully ass...

journal_title：Molecular microbiology

authors： Pizza M,Domenighini M,Hol W,Giannelli V,Fontana MR,Giuliani MM,Magagnoli C,Peppoloni S,Manetti R,Rappuoli R

更新日期：1994-10-01 00:00:00

abstract：:Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA). Pregnancy-specific VSA (VSA(PAM)), which include the PfEMP1 variant VAR2CSA, are targets of IgG-mediated...

journal_title：Molecular microbiology

authors： Barfod L,Bernasconi NL,Dahlbäck M,Jarrossay D,Andersen PH,Salanti A,Ofori MF,Turner L,Resende M,Nielsen MA,Theander TG,Sallusto F,Lanzavecchia A,Hviid L

更新日期：2007-01-01 00:00:00

abstract：:Sensory adaptation of low-abundance chemoreceptors in Escherichia coli requires assistance from high-abundance receptors, because only high-abundance receptors carry the carboxyl-terminal pentapeptide sequence NWETF that enhances adaptational covalent modification. Using membrane vesicles containing both high-abundanc...

journal_title：Molecular microbiology

authors： Li M,Hazelbauer GL

更新日期：2005-06-01 00:00:00

abstract：:Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (sigma) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in some cases, cau...

journal_title：Molecular microbiology

authors： Manganelli R,Voskuil MI,Schoolnik GK,Dubnau E,Gomez M,Smith I

更新日期：2002-07-01 00:00:00

abstract：:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is exposed on the surface of infected erythrocytes where it both acts as an important pathogenicity factor in malaria and undergoes antigenic variation as a means of immune evasion. Because the mammalian erythrocyte lacks a protein secretory machinery ther...

journal_title：Molecular microbiology

authors： Papakrivos J,Newbold CI,Lingelbach K

更新日期：2005-02-01 00:00:00

abstract：:Although iron is an essential nutrient, its toxicity at high levels necessitates regulated transport. In Gram-negative bacteria a central target for regulation is the TonB protein, an energy transducer that couples the cytoplasmic membrane proton motive force to active transport of (FeIII)-siderophore complexes across...

journal_title：Molecular microbiology

authors： Young GM,Postle K

更新日期：1994-03-01 00:00:00

abstract：:Bacterial surface layers (S-layers) are extracellular protein networks that act as molecular sieves and protect a large variety of archaea and bacteria from hostile environments. Atomic force microscopy (AFM) was used to asses the S-layer of Coryne-bacterium glutamicum formed of PS2 proteins that assemble into hexamer...

journal_title：Molecular microbiology

authors： Scheuring S,Stahlberg H,Chami M,Houssin C,Rigaud JL,Engel A

更新日期：2002-05-01 00:00:00

abstract：:The td group I intron interrupting the thymidylate synthase (TS) gene of phage T4 is a mobile intron that encodes the homing endonuclease I-TevI. Efficient RNA splicing of the intron is required to restore function of the TS gene, while expression of I-TevI from within the intron is required to initiate intron mobilit...

journal_title：Molecular microbiology

authors： Gibb EA,Edgell DR

更新日期：2010-10-01 00:00:00