Abstract：
:Severe acute inflammation in chronic inflammatory bowel disease is associated with large wound areas and ulcerations that show spontaneous hemorrhage or marked friability. Therefore, an enormous potential of hemostasis and wound healing is required. Coagulation studies demonstrate a deficiency of factor XIII that is important for both clot formation and wound healing. Consequently, the substitution of factor XIII may be beneficial; the first case reports present favorable clinical results. In a prospective pilot study, we treated 12 patients with therapy-resistant ulcerative colitis. The colitis activity index (CAI) and the endoscopic score (ES) according to Rachmilewitz were elevated; all patients suffered from hematochezia. After substitution therapy with factor XIII concentrate (1,250 U/d) the stool frequency dropped and no further hematochezia was detected. The CAI and the ES declined highly significantly. Because of these encouraging results two placebo-controlled multicenter trials have been initiated. In the first study, patients with acute stage of ulcerative colitis associated with severe intestinal blood loss are treated with two different dosages of factor XIII concentrate (1,250 and 500 U/d, respectively) or placebo for 10 days. In the second trial, patients with therapy-resistant ulcerative colitis with a lack of remission in spite of a consequent therapy for 2 weeks are included; factor XIII concentrate or placebo is administered for 10 days. The aim of both trials is an end of intestinal bleeding and the fostering of a more effective wound-healing process.
journal_name
Semin Thromb Hemostjournal_title
Seminars in thrombosis and hemostasisauthors
Lorenz R,Olbert P,Born Pdoi
10.1055/s-2007-999045subject
Has Abstractpub_date
1996-01-01 00:00:00pages
451-5issue
5eissn
0094-6176issn
1098-9064journal_volume
22pub_type
杂志文章,评审abstract：:Asymptomatic pulmonary embolism (PE) is present in at least one-third of patients with deep venous thrombosis (DVT). However, knowledge about its influence on the prognosis of patients is limited. The aim of this study was to assess the prognostic impact of asymptomatic PE in patients with DVT and to explore risk fact...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0036-1584351
更新日期：2017-02-01 00:00:00
abstract：:We present three clinical cases that illustrate some of the key features of the diagnosis and management of immune-mediated heparin-induced thrombocytopenia (HIT). The importance of having a high clinical suspicion for HIT in the appropriate clinical setting is emphasized. Early therapeutic decisions should be based o...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2004-831040
更新日期：2004-06-01 00:00:00
abstract：:Heparin preparations have been used for prophylaxis and treatment of deep vein thrombosis for many years. Several biologic effects of heparin are known. Since 1978, there have been several reports about reversible elevation in serum values of AST and ALT in patients and healthy volunteers given heparin in small and hi...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1055/s-2007-1002654
更新日期：1991-10-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) are thrombotic microangiopathies (TMAs) that can present in pregnancy. The presentation can be with typical microangiopathic features and thrombocytopenia, but there is also a significant risk of in-utero fetal loss. TTP presents m...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1587683
更新日期：2016-10-01 00:00:00
abstract：:Unfractionated heparin and LMMH were substituted with different lipophilic organic compounds. Specifically endpoint attached (LMMH-tyramine and LMMH-tyramine-FITC) and nonspecifically substituted heparins (acylated heparins, and LMMH-biotin and LMMH-cholesterol hemisuccinate) were obtained. The lipophilically substitu...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2007-1001902
更新日期：1994-01-01 00:00:00
abstract：:Hip replacement surgery carries a high risk of thromboembolic complications, and pharmacological prophylaxis is routinely adopted in clinical practice. Meta-analyses have indicated that low molecular weight heparins (LMWHs) are clinically superior to conventional prophylaxis with unfractionated heparin. These analyses...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:The pathophysiology of heparin-induced thrombocytopenia (HIT) is now known to be a complex process which involves platelets, vascular endothelium, and leukocytes. The activation products from these sites also contribute to the activation of coagulation and to the fibrinolytic deficit. While many of the markers of hemo...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:The quiescent vascular system in the adult body represents the imbalanced net outcome of overproduction of endogenous angiogenesis inhibitors and reduced levels of angiogenic factors. While some endogenous inhibitors are expressed under physiological conditions, they can also be generated in association with tumor gro...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2004-822973
更新日期：2004-02-01 00:00:00
abstract：:Protein S is a vitamin K-dependent plasma glycoprotein circulating in plasma at a concentration of around 350 nM. Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex. Protein S in plasma has multiple a...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0037-1604092
更新日期：2018-03-01 00:00:00
abstract：:The polymorphism in the composition and actions of heparin and the parallel complexity of the thrombotic process have led to the design of a cautious, methodical, and pragmatic program of development of the first low molecular heparin fraction presently available in France (CY 216). The main idea was always to present...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 临床试验,历史文章,杂志文章,随机对照试验
doi：10.1055/s-2007-1002737
更新日期：1989-10-01 00:00:00
abstract：:This epilogue represents a final summary of the issues discussed and highlighted at the International Summit on Differentiation of Low Molecular Weight Heparins (LMWHs). International scientists and physicians presented and discussed the physicochemical differences between LMWHs, and concluded that different productio...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Severe trauma is the leading cause of death globally. Though improved resuscitation, particularly early initiation, has reduced the 24-hour mortality rate, the overall morbidity and 30-day mortality remain high mostly due to massive hemorrhage and head injury in the early stages and sepsis and multiorgan failure later...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0039-3402428
更新日期：2020-03-01 00:00:00
abstract：:Immune thrombocytopenic purpura (ITP) is a bleeding disorder and is traditionally divided in acute and chronic forms based on the duration of the disease. Chronic ITP is characterized by a persistence of thrombocytopenia for more than 6 months. Ten to 20% of children with ITP and almost all adults will develop the chr...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-996054
更新日期：1998-01-01 00:00:00
abstract：:The articular problems of patients with hemophilia begin in infancy when minor injuries result in hemarthroses. Early continuous prophylaxis (from cradle to college) is of paramount importance because the immature skeleton is very sensitive to the complications of hemophilia; severe structural deficiencies may develop...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2005-922223
更新日期：2005-11-01 00:00:00
abstract：:The increased prevalence of the laboratory diagnosis of von Willebrand disease (vWD) in women presenting with menorrhagia has raised concerns regarding certain specifics in vWD testing in women, including when vWD testing should be done in relation to menses and whether testing should be done while the patient is not ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2006-947861
更新日期：2006-07-01 00:00:00
abstract：:Platelet-type von Willebrand disease (PT-VWD) and type 2B von Willebrand disease (2B-VWD) are rare bleeding disorders characterized by increased ristocetin-induced platelet aggregation (RIPA) at low concentrations of ristocetin. Diagnosis of either condition is not easy and the differential diagnosis between the two e...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0033-1364183
更新日期：2014-03-01 00:00:00
abstract：:Most plasma proteins are present in both normal and atherosclerotic intima, and their concentrations in intimal interstitial fluid are directly related to plasma concentration and molecular size. All intimal samples also contain soluble fibrin-fibrinogen-related antigens, consisting of variable mixtures of fibrinogen ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2007-999030
更新日期：1996-01-01 00:00:00
abstract：:It is generally accepted that the initial event in coagulation and intravascular thrombus formation is the exposure of the flowing blood to cell-surface protein, such as tissue factor (TF). Vascular injury and/or atherosclerotic plaque complication is responsible for this exposure, leading to clinical manifestations s...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0035-1564045
更新日期：2015-10-01 00:00:00
abstract：:Oral anticoagulants (OAs) are the drugs of choice for the prevention of recurrence and death in patients with venous thromboembolism (VTE). Oral anticoagulant treatment (OAT) aims to retard blood coagulation to obtain maximum protection against thromboembolic events with the lowest risk of bleeding. The intensity of O...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2006-955460
更新日期：2006-11-01 00:00:00
abstract：:Coagulation factor XII (FXII), formerly known as Hageman factor, is a plasma glycoprotein which exerts a kaleidoscope of biological functions, including the initiation of the intrinsic pathway of blood coagulation, the activation of the kallikrein-kinin system, and the generation of bradykinin and angiotensin. The lar...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1571338
更新日期：2016-09-01 00:00:00
abstract：:Human microbiota is a term conventionally used to define the normal flora of microbes living in all of us, most of which are resident in the gastrointestinal tract. Despite it having been known for some time that the vast majority of intestinal bacteria exert a strong influence on human life, recent technologic breakt...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1597903
更新日期：2017-09-01 00:00:00
abstract：:Persons with hematologic malignancies bleed for a variety of reasons, including alterations in platelet function and numbers, clotting factor deficiencies, circulating anticoagulants, and defects in vascular integrity. The management of bleeding begins with a full characterization of the hemostatic defect. Vitamin K d...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-976178
更新日期：2007-06-01 00:00:00
abstract：:There is ample evidence of an increased risk of venous thromboembolism (VTE) in inflammatory bowel disease (IBD). Recent large studies have quantified this risk showing that IBD patients run a 1.5 to 3.6 higher risk of developing VTE than healthy controls. The development of VTE in IBD seems to be multifactorial, resu...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0033-1343886
更新日期：2013-07-01 00:00:00
abstract：:With the advent of highly active antiretroviral therapy (HAART), dramatic improvements have been made in the quality and length of life in people living with HIV/AIDS (PLWA). Complications that are seen with increasing frequency in this group include venous thromboembolism events (VTE) and cardiovascular disease. Rece...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1328887
更新日期：2012-11-01 00:00:00
abstract：:Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. In the past two decades, more than 180 mutations in the FXI gene have been reported in patients with FXI deficiency, five of which show a founder effect (Cys38Arg, Gln88Stop, Cys128Stop, Glu117stop, an...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0029-1225764
更新日期：2009-06-01 00:00:00
abstract：:Schizophrenia, a disabling mental disorder, is characterized by brain atrophy, especially in the superior temporal gyrus and the medial temporal lobe, which includes the hippocampus and the amygdala. The model that better explains brain atrophy includes a trigger and a predisposing condition. The trigger is exemplifie...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0033-1357505
更新日期：2013-11-01 00:00:00
abstract：:Despite the improved therapeutic advances in the management of acute promyelocytic leukemia (APL), a significant early mortality during induction, also referred to as early death (ED), remains an obstacle for further improvement in outcome. Hemorrhagic complications are the most common cause of morbidity and mortality...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0039-1693478
更新日期：2019-09-01 00:00:00
abstract：:Rivaroxaban is approved in Europe and the United States for thromboprophylaxis following total joint arthroplasty. As the rate of obesity increases, confirming safety and efficacy in this patient population is paramount. This retrospective chart review assessed the efficacy and safety of rivaroxaban between two body m...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0038-1676319
更新日期：2019-03-01 00:00:00
abstract：:Physical injuries, especially road traffic injuries, are a leading cause of death and morbidity worldwide, ranking fifth among the leading causes of death in the United States. Immediate and early trauma deaths are mainly determined by primary brain injuries and/or hemorrhages, whereas late mortality is caused by seco...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0030-1254047
更新日期：2010-06-01 00:00:00
abstract：:Defective systemic fibrinolysis and articular persistence of fibrinlike material are well recognized in RA. Perturbation of the major plasma protease inhibitors, A1AT, A2MG, and AT III, was explored in RA, psoriatic arthritis, and Reiter's syndrome. Experimental evidence is presented and assessed with respect to the p...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2007-1004400
更新日期：1985-10-01 00:00:00
