Abstract：
:The emergence of resistance against most of the drugs in current use against malaria has aggravated the disease burden in endemic regions. Several plants species have been used for treatment of malaria in traditional/cultural health systems. Bergenia ciliata, used traditionally for treatment of fever by local communities in the Himalayan Region, was evaluated for its plausible role as an antimalarial. Phytochemical screening of the ethanolic leaf extract of B. ciliata (ELEBC) revealed the presence of phenols, flavonoids, steroids and diterpenes. The extract showed good in vitro antiplasmodial activity, with an IC50 <10 μg/ml. Acute toxicity of the extract was observed to be >5 g/kg, which is considered toxicologically safe for oral administration. When tested in vivo, different concentrations of the extract (250 to 1,000 mg/kg) exhibited considerable chemosuppression on day 7, in a dose-dependent manner. Maximum chemosuppression was observed to be 87.50% at 1,000 mg/kg. Administration of ELEBC (750 and 1,000 mg/kg) significantly (p < 0.0005) enhanced the mean survival time of mice in comparison to infected control, which exhibited a mean survival time of 8.6 ± 1.5 days. Study reports presence of considerable in vitro and in vivo antimalarial activity in ethanolic leaf extract of B. ciliata for first time. Hence, the ethnopharmacological usage of the plant for treating fever is confirmed with experimental evidence.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Walter NS,Bagai U,Kalia Sdoi
10.1007/s00436-013-3487-zsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
3123-8issue
9eissn
0932-0113issn
1432-1955journal_volume
112pub_type
杂志文章abstract：:Increased gametocytemia in infections with resistant strains of Plasmodium species and their enhanced transmissibility are a matter of concern in planning and evaluating the impact of malaria control strategies. Various studies have determined weekly gametocyte carriage in response to antimalarial drugs in clinical tr...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3789-9
更新日期：2014-04-01 00:00:00
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journal_title：Parasitology research
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doi：10.1007/BF00931823
更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-003-1040-1
更新日期：2004-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-002-0775-4
更新日期：2003-03-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050550
更新日期：1999-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4788-1
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更新日期：2006-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
abstract：:Parasites from Flensburg fjord, northern German Baltic coast, were investigated under regard of the component, guild, and supra community level. At least, 28 host species of the guilds snails, planktonic and benthic crustaceans, and fish (exclusively small-sized species) were infected by 53 parasite species (28 autoge...
journal_title：Parasitology research
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doi：10.1007/s00436-008-1218-7
更新日期：2009-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0568-x
更新日期：2007-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-010-2193-3
更新日期：2011-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-6024-2
更新日期：2018-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5201-4
更新日期：2016-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3067-7
更新日期：2012-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050590
更新日期：1999-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050359
更新日期：1998-01-01 00:00:00
abstract：:The induction of protective immunity to Leishmania amazonensis was investigated by injection of parasite clones of low and medium virulence into susceptible mice. To this end, L. amazonensis were cloned by limiting dilution and the clones' virulence was evaluated by the course of infection in susceptible mice. Clones ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050321
更新日期：1997-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1071-8
更新日期：2008-09-01 00:00:00
abstract：:The endemic avifauna of Arabia is unique and characteristic through the whole region. Little is known about these birds and their ectoparasites. The Arabian partridge Alectoris melanocephala (Rüppell, 1835) and Philby's partridge Alectoris philbyi Lowe, 1934 are two endemic species which are distributed through the Sa...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5219-7
更新日期：2016-11-01 00:00:00
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journal_title：Parasitology research
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更新日期：2015-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-012-2919-5
更新日期：2012-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1067-4
更新日期：2008-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932628
更新日期：1994-01-01 00:00:00
abstract：:Both the oncospheral tegument and the hook region membrane (HRM) of Echinococcus multilocularis hexacanths originate from a syncytial binucleate complex that appears in the early stage of morphogenesis and organogenesis of the hexacanth larva. The primordium of this binucleate complex forms a binucleate syncytial cap ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5752-7
更新日期：2018-03-01 00:00:00
abstract：:The chemotherapeutic interventions against visceral leishmaniasis (VL) are limited and facing serious concerns of toxicity, high cost, and emerging drug resistance. There is a greater interest in new drug developments from traditionally used medicinal plants which offers unprecedented diversity in structures and bioac...
journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
abstract：:Numerous nematodes were found in the rectum of three fish species Synodontis ocellifer, S. nigrita, and S. schall (Mochokidae, Siluriformes) from the Gambia River and Mare Simenti, National Park Niokolo Koba, Senegal. A nematode species Raillietnema synodontisi Vassiliadès, 1973 (host S. ocellifer), is redescribed usi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0869-0
更新日期：2008-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06381-z
更新日期：2019-09-01 00:00:00
abstract：:Legionella were detected with the direct DNA extraction method, Legionella culture method, and free-living amoebae (FLA) culture method from weak alkaline carbonate spring water in Taiwan. Moreover, we also investigated the existence of Acanthamoeba, Hartmannella, and Naegleria, ubiquitous FLA in aquatic environments,...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2366-8
更新日期：2011-11-01 00:00:00
abstract：:Plasmodium falciparum (Pf) refurbishes the infected erythrocytes by exporting a myriad of parasite proteins to the host cell. A novel exported protein family 'Plasmodium Helical Interspersed Subtelomeric' (PHIST) has gained attention for its significant roles in parasite biology. Here, we have collected and analysed a...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-019-06420-9
更新日期：2019-10-01 00:00:00
abstract：:In April 2000, we collected and analyzed for parasites 174 feces belonging to 48 different and identified Cantabrian capercaillies (Tetrao urogallus cantabricus) from 39 lek sites in the Cantabrian Mountains (North Spain) and determined the factors related with prevalence and abundance of propagule excretion: (1) inte...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1015-3
更新日期：2008-08-01 00:00:00
