Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis-infected rats.

Abstract:

:Gonadectomized male laboratory rats were given 0.06 mg/kg estradiol benzoate daily for 14 days before being inoculated with 50 third-stage larvae of Parastrongylus malaysiensis. Hormone treatment was continued until the rats were killed. The numbers of larvae in the brain and of adult worms in the pulmonary area of the rats were determined every 7 days after the inoculation. It was found that the rats treated daily with estradiol benzoate had significantly and consistently higher numbers of larvae and adult worms as compared with the controls. The number of total leukocytes increased significantly after the rats were infected. The results show that estradiol-treated rats become susceptible to P. malaysiensis infection, which may indicate that the immunosuppressive effects of testosterone observed in earlier studies may partly be caused by estradiol that was peripherally aromatized from testosterone.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Kamis AB,Ahmad RA,Badrul-Munir MZ

doi

10.1007/BF00932628

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

74-7

issue

1

eissn

0932-0113

issn

1432-1955

journal_volume

80

pub_type

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