Psychometric evaluation of ADAS-Cog and NTB for measuring drug response.

Abstract:

AIMS:To conduct a psychometric analysis to determine the adequacy of instruments that measure cognition in Alzheimer's disease trials. BACKGROUND:Both the Alzheimer's Disease Assessment Scale - Cognition (ADAS-Cog) and the Neuropsychological Test Battery (NTB) are validated outcome measures for clinical trials in Alzheimer's disease and are approved also for regulatory purposes. However, it is not clear how comparable they are in measuring cognitive function. In fact, many recent trials in Alzheimer's disease patients have failed and it has been questioned if ADAS-Cog still is a sensitive measure. MATERIALS AND METHODS:The present paper examines the psychometric properties of ADAS-Cog and NTB, based on a post hoc analysis of data from a clinical trial (NCT01024660), which was conducted by AstraZeneca, in mild-to-moderate Alzheimer's disease (AD) patients, with a Mini Mental State Examination (MMSE) Total score 16-24. Acceptability, reliability, different types of validity and ability to detect change were assessed using relevant statistical methods. Total scores of both tests, as well as separate domains of both tests, including the Wechsler Memory Scale (WMS), Rey Auditory Verbal Learning Test (RAVLT) and Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency Condition, were analyzed. RESULTS:Overall, NTB performed well, with acceptable reliability and ability to detect change, while ADAS-Cog had insufficient psychometric properties, including ceiling effects in 8 out of a total of 11 ADAS-Cog items in mild AD patients, as well as low test-retest reliability in some of the items. DISCUSSION:Based on a direct comparison on the same patient sample, we see advantages of the NTB compared with the ADAS-Cog for the evaluation of cognitive function in the population of mild-to-moderate AD patients. The results suggest that not all of ADAS-Cog items are relevant for both mild and moderate AD population. CONCLUSIONS:This validation study demonstrates satisfactory psychometric properties of the NTB, while ADAS-Cog was found to be psychometrically inadequate.

journal_name

Acta Neurol Scand

authors

Karin A,Hannesdottir K,Jaeger J,Annas P,Segerdahl M,Karlsson P,Sjögren N,von Rosen T,Miller F

doi

10.1111/ane.12153

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

114-22

issue

2

eissn

0001-6314

issn

1600-0404

journal_volume

129

pub_type

杂志文章
  • Nasal spray desmopressin treatment of bladder dysfunction in patients with multiple sclerosis.

    abstract::Bladder dysfunction with increased voiding frequency and incontinence is a common problem in patients with multiple sclerosis (MS). In the present study, the effect of the synthetic vasopressin analogue, desmopressin, was evaluated on the voiding frequency in 26 patients with MS suffering from socially handicapping vo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.1996.tb00035.x

    authors: Fredrikson S

    更新日期:1996-07-01 00:00:00

  • Epidemiological and clinical characteristics of myasthenia gravis in Belgrade, Yugoslavia (1983-1992).

    abstract::This is the first epidemiological study of myasthenia gravis (MG) in the area of Belgrade. During the survey period (1983 1992), 124 incidental cases of MG were observed, producing an average annual incidence rate of 7.1 per million population (women, 8.3; men, 5.8). Age and sex specific incidence rates for females de...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb00733.x

    authors: Lavrnić D,Jarebinski M,Rakocević-Stojanović V,Stević Z,Lavrnić S,Pavlović S,Trikić R,Tripković I,Nesković V,Apostolski S

    更新日期:1999-09-01 00:00:00

  • Familial recurrent cranial nerve palsies.

    abstract::Family cases of recurrent cranial nerve palsies are seldom reported. This paper presents a family with recurrent facial and ocular nerve palsies in 2 brothers. Their father and his sister had Bell's palsies. Examinations provided no explanation. Six previous reports of families with recurrent cranial nerve palsies are...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb03699.x

    authors: Sørensen TT

    更新日期:1988-12-01 00:00:00

  • Haplotype analysis of the DM1 locus in the Serbian population.

    abstract:OBJECTIVES:Analysis of the CTG-repeat number and three biallelic markers, Alu(+/-), HinfI(+/-), and TaqI(+/-), in the DMPK gene in healthy and myotonic dystrophy type 1 (DM1) Serbian individuals. Also, the consideration of haplotypes in the light of the proposed models of CTG-repeat evolution and origin of the DM1 muta...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00402.x

    authors: Krndija D,Savić D,Mladenović J,Rakocević-Stojanović V,Apostolski S,Todorović S,Romac S

    更新日期:2005-04-01 00:00:00

  • Meningeal carcinomatosis: CSF cytology, immunocytochemistry and biochemical tumor markers.

    abstract::CSF cytology, immunocytochemistry and biochemical tumor markers were compared in 12 patients with a meningeal carcinomatosis regarding diagnostic significance and therapy control; 50 samples were investigated. Cytology was tumor-positive in 39 samples and immunocytochemistry in 45 samples. Intrathecally produced tumor...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1994.tb02653.x

    authors: Oschmann P,Kaps M,Völker J,Dorndorf W

    更新日期:1994-05-01 00:00:00

  • Turns-amplitude analysis and motor unit potential analysis in myasthenia gravis.

    abstract:OBJECTIVES:The aims of this study were to investigate myopathic changes in myasthenia gravis (MG) by using turns-amplitude analysis (TAA) and quantitative motor unit potential duration analysis (MUPan), to correlate myopathic changes with severity and duration of the disease and the results of diagnostic tests includin...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2000.90303.x

    authors: Odabasi Z,Kuruoglu R,Oh SJ

    更新日期:2000-05-01 00:00:00

  • Studies on the clustering of multiple sclerosis in Finland I: Comparison between the domiciles and places of birth in selected subpopulations.

    abstract::Further studies pm yjr rofr,op;phu pg ,i;yo;r dv;rtpdod (MS) IN Finland were carried out in three different types of geographical unit: in counties, combined clerical districts, and single clerical district. For longitudinal studies, the prevalence of MS by present domicile was compared to that by place of birth, and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb01362.x

    authors: Wikström J,Palo J

    更新日期:1975-02-01 00:00:00

  • Memory with emotional content, brain amygdala and Alzheimer's disease.

    abstract:OBJECTIVES:A highly adaptive aspect of human memory is the enhancement of explicit, consciously accessible memory by emotional stimuli. We studied the performance of Alzheimer's disease (AD) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala an...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2008.01132.x

    authors: Schultz RR,de Castro CC,Bertolucci PH

    更新日期:2009-08-01 00:00:00

  • EMG before and after cervical anterior discectomy.

    abstract:INTRODUCTION:In patients with cervical root syndromes, the relation between clinical findings and EMG results, the value of the registration of the H-reflex latency of the flexor carpi radial muscle (HFCR) and the rate of recovery of EMG abnormalities following surgery are unclear. METHODS:In 68 patients with cervical...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.1995.tb00138.x

    authors: van den Bent MJ,Oosting J,Laman DM,van Duijn H

    更新日期:1995-10-01 00:00:00

  • Algorithm for lamotrigine dose adjustment before, during, and after pregnancy.

    abstract:BACKGROUND:Treatment with lamotrigine (LTG) during pregnancy is associated with a pronounced risk of seizure deterioration, because pregnancy accelerates LTG elimination. The extent to which pregnancy affects LTG pharmacokinetics is unpredictable and varies considerably among patients. AIM:We propose an algorithm for ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01627.x

    authors: Sabers A

    更新日期:2012-07-01 00:00:00

  • Psychological characteristics of patients with myotonic dystrophy type 1.

    abstract:OBJECTIVES:Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy. It is associated with motor symptoms but patients also display non-motor symptoms such as particular personality traits. Studies have reported mixed results about personality characteristics which may be attributable to small ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12356

    authors: Bertrand JA,Jean S,Laberge L,Gagnon C,Mathieu J,Gagnon JF,Richer L

    更新日期:2015-07-01 00:00:00

  • Clinical features of the spinal form of multiple sclerosis.

    abstract::Out of a data pool of 1271 patients with Multiple Sclerosis (MS) a total of 109 cases are selected having a sole spinal symptomatology throughout the course of the disease. This group differs in three particular features from the non-spinal forms of MS: In this group there is a higher percentage of females, the age at...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1978.tb02832.x

    authors: Poser S,Herrmann-Gremmels I,Wikström J,Poser W

    更新日期:1978-02-01 00:00:00

  • Restless legs syndrome and cerebrovascular/cardiovascular events: Systematic review and meta-analysis.

    abstract:OBJECTIVE:We performed a systematic review and meta-analysis to evaluate the proposed association of restless legs syndrome (RLS) with cerebrovascular/cardiovascular outcomes. METHODS:We calculated the corresponding odds ratios on the prevalence of cerebrovascular/cardiovascular risk factors and standardized mean diff...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ane.12848

    authors: Katsanos AH,Kosmidou M,Konitsiotis S,Tsivgoulis G,Fiolaki A,Kyritsis AP,Giannopoulos S

    更新日期:2018-01-01 00:00:00

  • Serum elevation of high density lipoprotein (HDL) cholesterol in epileptic patients taking carbamazepine or phenytoin.

    abstract::Serum lipids and the cholesterol concentration in the high density lipoprotein (HDL) fraction were measured in epileptic patients taking either carbamazepine or phenytoin as single drug treatment. There was a significant increase in HDL-cholesterol levels in patients taking both phenytoin and carbamazepine. Serum tota...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb03067.x

    authors: O'Neill B,Callaghan N,Stapleton M,Molloy W

    更新日期:1982-02-01 00:00:00

  • Caregiver's burden in disorders of consciousness: a longitudinal study.

    abstract:OBJECTIVES:To study the changes in the burden of informal caregivers of patients with disorders of consciousness (DOC) over time. MATERIALS AND METHODS:Short Form-12, Family Strain Questionnaire, Beck Depression Inventory and Coping Orientations to Problem Experiences were administered. RESULTS:Data collected on 216 ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12550

    authors: Covelli V,Sattin D,Giovannetti AM,Scaratti C,Willems M,Leonardi M

    更新日期:2016-11-01 00:00:00

  • Pisa syndrome in a cohort of Alzheimer's disease patients.

    abstract::Three Alzheimer's disease patients with Pisa syndrome were presented. These patients were treated with cholinesterase inhibitors within a post-marketing surveillance study. The clinical and pharmacological histories of these patients suggest a relation between cholinesterase inhibitors and the pleurothotonus. The diff...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00388.x

    authors: Vanacore N,Suzzareddu G,Maggini M,Casula A,Capelli P,Raschetti R

    更新日期:2005-03-01 00:00:00

  • Decompressive craniectomy: technical note.

    abstract::Decompressive craniectomy is a neurosurgical technique in which a portion of the skull is removed to reduce intracranial pressure. The rationale for this procedure is based on the Monro-Kellie Doctrine; expanding the physical space confining edematous brain tissue after traumatic brain injury will reduce intracranial ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.2010.01397.x

    authors: Quinn TM,Taylor JJ,Magarik JA,Vought E,Kindy MS,Ellegala DB

    更新日期:2011-04-01 00:00:00

  • Decreased plasma alanine and isoleucine in Huntington's disease.

    abstract::Amino acid concentrations in plasma of patients with Huntington's disease (HD) were determined in 16 patients and 21 age- and sex-matched healthy controls. Alanine and isoleucine were significantly decreased in HD plasma whereas arginine, histidine, leucine, lysine, ornithine, proline, serine, threonine, tyrosine, and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb00438.x

    authors: Reilmann R,Rolf LH,Lange HW

    更新日期:1995-03-01 00:00:00

  • The evidence for switching dibenzazepines in people with epilepsy.

    abstract::The dibenzazepines particularly carbamazepine are associated with known adverse effects (AEs) and drug to drug interactions. Eslicarbazepine acetate (ESL) is structurally distinct from other members of the dibenzazepine family and has the advantage of once daily dosing. Observational and trial data report successful s...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.13248

    authors: Watkins L,O'Dwyer M,Oak K,Lawthom C,Maguire M,Thomas R,Shankar R

    更新日期:2020-08-01 00:00:00

  • Carotid artery stenting: Current state of evidence and future directions.

    abstract::Both carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for carotid artery stenosis. Several randomized controlled trials (RCTs) have compared CEA to CAS in the treatment of carotid artery stenosis. These studies have suggested that CAS is more strongly associated with periprocedural ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.13062

    authors: Lamanna A,Maingard J,Barras CD,Kok HK,Handelman G,Chandra RV,Thijs V,Brooks DM,Asadi H

    更新日期:2019-04-01 00:00:00

  • Cysticercosis of the cerebellopontine angle cistern mimicking epidermoid inclusion cyst.

    abstract::We report a case of a cystic lesion in the left cerebellopontine (CP) angle cistern. The magnetic resonance (MR) imaging features closely resembled an epidermoid inclusion cyst, and was interpreted as such. However, at surgery and on histopathological examination the lesion was found to be a cysticercus cyst. It may b...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb07359.x

    authors: Singh S,Gibikote SV,Bannur U,Chacko G,Korah IP,Rajshekhar V

    更新日期:1999-04-01 00:00:00

  • The increasing prevalence of Parkinson's disease in Estonia.

    abstract:OBJECTIVES:A previous epidemiological study of Parkinson's disease (PD) in the county of Tartu, Estonia, found an adjusted prevalence rate of 152/100 000 persons. We aimed to determine PD prevalence almost 20 years later, as well as evaluate any dynamic changes in disease frequency compared to the first study. METHODS...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12948

    authors: Kadastik-Eerme L,Taba N,Asser T,Taba P

    更新日期:2018-09-01 00:00:00

  • Thymic lymphoepitheliomas and skeletal muscle expressing common antigen(s).

    abstract::Rabbit antiserum to a citric acid extract of human skeletal muscle (CA) stained epithelial thymoma cells as well as skeletal muscle. Thymomas from two myasthenia gravis (MG) patients showing no circulating anti-CA antibodies prior to thymectomy were also stained by the antiserum. Thus, in these patients as well, the t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb03300.x

    authors: Gilhus NE,Matre R,Aarli JA,Hofstad H,Thunold S

    更新日期:1986-04-01 00:00:00

  • Levetiracetam in Meige's syndrome.

    abstract::The spontaneous occurrence of blepharospasm and dystonic movements in face muscles, particularly those of the perioral and mandibular regions, has been named as Meige's disease which was first described by Henry Meige in 1910. We report the case of a woman with Meige's syndrome whose symptoms improved with the use of ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00624.x

    authors: Yardimci N,Karatas M,Kilinc M,Benli S

    更新日期:2006-07-01 00:00:00

  • Isolated seizures in rats do not cause neuronal injury.

    abstract:BACKGROUND:Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. METHODS:We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01521.x

    authors: Acosta MT,Munashinge J,Zhang L,Guerron DA,Vortmeyer A,Theodore WH

    更新日期:2012-01-01 00:00:00

  • Population-based incidence and clinical characteristics of idiopathic intracranial hypertension.

    abstract:OBJECTIVE:To validate the diagnosis of idiopathic intracranial hypertension (IIH) from the Swedish National Patient Register (NPR) and investigate the incidence of IIH, as well as co-morbidities and medication use in a large Swedish population-based sample. METHODS:We searched the NPR to find all patients ≥18 years ol...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12742

    authors: Sundholm A,Burkill S,Sveinsson O,Piehl F,Bahmanyar S,Nilsson Remahl AIM

    更新日期:2017-11-01 00:00:00

  • Hip fracture after first-ever stroke: a population-based study.

    abstract:OBJECTIVES:The aim of this study is to estimate the risk of hip fracture after first-ever stroke, using a nationwide population-base data set and a retrospective cohort design. MATERIALS AND METHODS:The cohort study involved 18,413 patients surviving a first-ever stroke during the 12-year period from 1997 to 2008. Ano...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12301

    authors: Lin HL,Lin HC,Tseng YF,Liao HH,Worly JA,Pan CY,Hsu CY

    更新日期:2015-03-01 00:00:00

  • Variations of brain stem auditory evoked potentials correlated to duration and severity of multiple sclerosis.

    abstract::A total of 158 recordings of brain stem auditory evoked potentials (BAEPs) were obtained in 121 patients with multiple sclerosis. A statistically significant increased incidence of abnormality and diffusely abnormal recordings was found with increasing duration and severity of symptoms. Alterations in follow-up record...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1980.tb01478.x

    authors: Kjaer M

    更新日期:1980-03-01 00:00:00

  • Superior cerebellar artery territory stroke.

    abstract:OBJECTIVES:The purpose of this study was to clarify etiologic factors, prior symptoms and clinical features of isole superior cerebellar artery (SCA) territory infarcts. METHODS:All data were collected from consecutive 21 patients with isole SCA infarcts involved on computerized tomography. RESULTS:The risk factors i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb07310.x

    authors: Erdemoglu AK,Duman T

    更新日期:1998-10-01 00:00:00

  • Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients.

    abstract:OBJECTIVE:The present study focused on human leukocyte antigen (HLA) DQB1, DQA1 and DRB1 allelic variation according to ethnicity and analyzed whether susceptibility to multiple sclerosis (MS) depends on population characteristics. METHODS:Eighty-eight healthy African-Brazilians and 92 healthy white Brazilians living ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00750.x

    authors: Alves-Leon SV,Papais-Alvarenga R,Magalhães M,Alvarenga M,Thuler LC,Fernández y Fernandez O

    更新日期:2007-05-01 00:00:00