Abstract:
:Six members of a family had a neurologic disease with autosomal dominant transmission and adolescent onset of progressive wasting of predominantly distal axial muscles and muscles innervated by cranial nerves V, VII, X, and XII, leading to severe morbidity in adulthood. Muscle biopsy of the propositus revealed "ragged-red" fibers, while electromyography and autopsy material were consisted with a neurogenic disease. The case seemed unique to any clinicogenetic nosology, because it was associated with a cardiac conduction defect, a mitochondrial abnormality in skeletal muscle, and a course, distribution, and degree of weakness that included features of both chronic spinal muscular atrophy and amyotrophic lateral sclerosis.
journal_name
Neurologyjournal_title
Neurologyauthors
Dobkin BH,Verity MAdoi
10.1212/wnl.26.8.754subject
Has Abstractpub_date
1976-08-01 00:00:00pages
754-63issue
8eissn
0028-3878issn
1526-632Xjournal_volume
26pub_type
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