Rate and predictors of non-AIDS events in a cohort of HIV-infected patients with a CD4 T cell count above 500 cells/mm³.

abstract：:We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected control...

journal_title：AIDS research and human retroviruses

authors： Hasse B,Ledergerber B,Egger M,Flepp M,Bachmann S,Bernasconi E,Egger M,Guyot S,Hirschel B,Weber R,Günthard HF,Swiss HIV Cohort Study.

更新日期：2004-09-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:Foamy viruses are a genus of complex retroviruses that infect a wide variety of mammals. However, a clear association with any disease process has yet to be proven for these viruses. A higher human seroprevalence was reported in African populations, perhaps due to exposure to simian foamy viruses (SFV) endemic in prim...

journal_title：AIDS research and human retroviruses

authors： Goepfert PA,Ritter GD Jr,Peng X,Gbakima AA,Zhang Y,Mulligan MJ

更新日期：1996-12-10 00:00:00

abstract：:Sequences from the nef/LTR overlap region of the human immunodeficiency virus type 2 (HIV-2) genome were amplified from uncultured peripheral blood mononuclear cells (PBMCs) from 40 HIV-2-infected individuals in The Gambia, West Africa. Additional sequences from the plasma of three blood donors were also derived. Anal...

journal_title：AIDS research and human retroviruses

authors： Berry N,Ariyoshi K,Balfe P,Tedder R,Whittle H

更新日期：2001-02-10 00:00:00

abstract：:Abstract Multiple HIV-1 subtypes and circulating recombinant forms (CRFs) are known to cocirculate in Africa. In West Africa, the high prevalence of CRF02_AG, and cocirculation of subtype A, CRF01_AE, CRF06_cpx, and other complex intersubtype recombinants has been well documented. Mali, situated in the heart of West A...

journal_title：AIDS research and human retroviruses

authors： Imamichi H,Koita O,Dabitao D,Dao S,Ibrah M,Sogoba D,Dewar RL,Berg SC,Jiang MK,Parta M,Washington JA,Polis MA,Lane HC,Tounkara A

更新日期：2009-01-01 00:00:00

abstract：:Our goal has been to develop a safe and effective system that would allow us to explore the functions of the human immunodeficiency virus (HIV) envelope. We have generated a human lymphoid cell line (TF228.1.16) that stably expresses functional HIV envelope proteins on its cell surface, and therefore closely mimics th...

journal_title：AIDS research and human retroviruses

authors： Jonak ZL,Clark RK,Matour D,Trulli S,Craig R,Henri E,Lee EV,Greig R,Debouck C

更新日期：1993-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

journal_title：AIDS research and human retroviruses

authors： Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

更新日期：2017-11-01 00:00:00

abstract：:The relative importance of routes of transmission of human T cell lymphotropic virus type 1 (HTLV-1) in Guinea-Bissau is largely unknown; vertical transmission is thought to be important, but there are very few existing data. We aimed to examine factors associated with transmission in mothers and children in Guinea-Bi...

journal_title：AIDS research and human retroviruses

authors： van Tienen C,McConkey SJ,de Silva TI,Cotten M,Kaye S,Sarge-Njie R,da Costa C,Gonçalves N,Parker J,Vincent T,Jaye A,Aaby P,Whittle H,Schim van der Loeff M

更新日期：2012-06-01 00:00:00

abstract：:Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. I...

journal_title：AIDS research and human retroviruses

authors： Heinson AI,Woo J,Mukim A,White CH,Moesker B,Bosque A,Spina CA,Woelk CH,Macarthur BD,Beliakova-Bethell N

更新日期：2020-11-10 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CR...

journal_title：AIDS research and human retroviruses

authors： Mamadou S,Montavon C,Ben A,Djibo A,Rabiou S,Mboup S,Delaporte E,Peeters M

更新日期：2002-07-01 00:00:00

abstract：:Regression of feline immunodeficiency virus (FIV) infection was observed in seven of nine vertically infected kittens born to two chronically infected mother cats. Both provirus and nonmaternal FIV antibody were detected in all kittens by 4 weeks of age but only three of the seven kittens were positive by blood mononu...

journal_title：AIDS research and human retroviruses

authors： O'Neil LL,Burkhard MJ,Obert LA,Hoover EA

更新日期：1997-05-20 00:00:00

abstract：:In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug r...

journal_title：AIDS research and human retroviruses

authors： Saravanan S,Gomathi S,Kausalya B,Boobalan J,Murugavel KG,Balakrishnan P,Mothi SN,Solomon SS,Kumarasamy N,Selvamuthu P,Solomon S,Smith DM

更新日期：2015-06-01 00:00:00

abstract：:This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Schapiro JM,Winters MA,Merigan TC

更新日期：1998-05-01 00:00:00

abstract：:With improved survival and aging, more persons living with HIV/AIDS (PLWHA) are at risk for colorectal cancer (CRC). This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort. Patients were followed beginning at age 50 years during a study period from Janua...

journal_title：AIDS research and human retroviruses

authors： Burkholder GA,Tamhane AR,Appell LE,Willig JH,Saag MS,Raper JL,Westfall AO,Mugavero MJ

更新日期：2015-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with Burkitt's lymphoma (BL) in normal individuals and immunoblastic B cell lymphomas in immunosuppressed or HIV-infected individuals. SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors also may develop spontaneous ...

journal_title：AIDS research and human retroviruses

authors： Mosier DE,Picchio GR,Kirven MB,Garnier JL,Torbett BE,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-05-01 00:00:00

abstract：:We set out to investigate whether there are clinically significant consequences when children with perinatal exposure to single-dose nevirapine are initiated on a nonnucleoside reverse transcriptase inhibitor (NNRTI) containing a highly active antiretroviral therapy (HAART) regimen. We carried out a chart and database...

journal_title：AIDS research and human retroviruses

authors： Musiime V,Ssali F,Kayiwa J,Namala W,Kizito H,Kityo C,Mugyenyi P

更新日期：2009-10-01 00:00:00

abstract：:In this report we have highlighted only a few examples of the extensive efforts underway to better understand the process of HIV pathogenesis, to develop new therapeutic agents to inhibit virus replication, and to identify strategies to restore damage done to the immune system during HIV disease progression. It is exp...

journal_title：AIDS research and human retroviruses

authors： Miller RH,Turk SR,Black RJ,Bridges S,Sarver N

更新日期：1996-07-01 00:00:00

abstract：:Older HIV-positive patients may experience reduced benefit and increased toxicities from combination antiretroviral therapies (cART) due to late diagnosis, weakened immune systems, and other age-related physiological changes. This study investigates the effect of age on time to virologic suppression and CD4 cell count...

journal_title：AIDS research and human retroviruses

authors： Szadkowski L,Tseng A,Walmsley SL,Salit I,Raboud JM

更新日期：2012-12-01 00:00:00

abstract：:We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. ...

journal_title：AIDS research and human retroviruses

authors： Schwartz D,Sharma U,Busch M,Weinhold K,Matthews T,Lieberman J,Birx D,Farzedagen H,Margolick J,Quinn T

更新日期：1994-12-01 00:00:00

abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

journal_title：AIDS research and human retroviruses

authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

更新日期：1994-11-01 00:00:00

abstract：:The feasibility and effectiveness of a hospital-based exercise-training program followed by a home-based program for improving fitness, strength, and changes in body composition in children and adolescents with HIV were evaluated. Subjects participated in nonrandomized 24-session, hospital supervised exercise training...

journal_title：AIDS research and human retroviruses

authors： Miller TL,Somarriba G,Kinnamon DD,Weinberg GA,Friedman LB,Scott GB

更新日期：2010-03-01 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:The HIV-1 Nef protein is known to be secreted, and our group has shown that Nef is secreted from nef-transfected and HIV-1-infected cells in small exosome-like vesicles (d. 40-100 nm). The role of secreted Nef remains to be fully characterized. Thus, it is important to characterize the nature of and the mechanisms reg...

journal_title：AIDS research and human retroviruses

authors： Ali SA,Huang MB,Campbell PE,Roth WW,Campbell T,Khan M,Newman G,Villinger F,Powell MD,Bond VC

更新日期：2010-02-01 00:00:00

abstract：:Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives...

journal_title：AIDS research and human retroviruses

authors： Montagne J,Jalinot P

更新日期：1995-09-01 00:00:00

abstract：:We report the results of an external quality control program, including 17 Italian centers involved in the care of patients infected by HIV, to evaluate CD4 T cell count proficiency and reproducibility. The centers received two commercial stabilized blood preparations, one with "normal" and one with "low" CD4 T cell c...

journal_title：AIDS research and human retroviruses

authors： Martini F,D'Offizi G,Girardi E,Vitale A,Cimini E,Mollicone B,Vlassi C,Aiuti F,Other Members of 2005 Italian CD4 Quality Control Network.

更新日期：2007-06-01 00:00:00

abstract：:Raltegravir, a novel HIV-1 integrase inhibitor, has superior efficacy with optimized background treatment (OBT) vs. placebo + OBT in treatment-experienced HIV-1 patients. This study assessed the long-term cost effectiveness of raltegravir from a Spanish National Healthcare System perspective. A cohort-state-transition...

journal_title：AIDS research and human retroviruses

authors： Chaudhary MA,Moreno S,Kumar RN,Nocea G,Elbasha E

更新日期：2009-07-01 00:00:00

abstract：:The U.S. military represents a unique population within the human immunodeficiency virus 1 (HIV-1) pandemic. The last comprehensive study of HIV-1 in members of the U.S. Navy and Marine Corps (Sea Services) was completed in 2000, before large-scale combat operations were taking place. Here, we present molecular charac...

journal_title：AIDS research and human retroviruses

authors： Heipertz RA Jr,Sanders-Buell E,Kijak G,Howell S,Lazzaro M,Jagodzinski LL,Eggleston J,Peel S,Malia J,Armstrong A,Michael NL,Kim JH,O'Connell RJ,Scott PT,Brett-Major DM,Tovanabutra S

更新日期：2013-10-01 00:00:00

abstract：:The majority of AIDS patients will experience some degree of dementia induced by human immunodeficiency virus (HIV-1). In this study, we report that treatment of human brain tissue with envelope gp120 of HIV-1 did not cause neuronal death but did cause astrocyte alterations and/or death. Human astrocyte cultures showe...

journal_title：AIDS research and human retroviruses

authors： Pulliam L,West D,Haigwood N,Swanson RA

更新日期：1993-05-01 00:00:00

abstract：:Epidemiological and experimental data suggest that both robust neutralizing antibodies and potent cellular responses play important roles in controlling primary HIV-1 infection. In this study we have investigated the induction of systemic and mucosal immune responses to HIV gp120 monomer immunogen administered intrana...

journal_title：AIDS research and human retroviruses

authors： Bielinska AU,Janczak KW,Landers JJ,Markovitz DM,Montefiori DC,Baker JR Jr

更新日期：2008-02-01 00:00:00