Abstract:
:The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is known of the developmental changes that occur in the early teen years, prior to the age of highest psychosis risk. Data were collected from 71 participants (42 subjects with 22q11DS and 29 control subjects) at Time 1 (T1) and Time 2 (T2), approximately 3.5 years later. The 22q11DS group was significantly lower functioning than controls on IQ, neurocognition, and academic achievement at both T1 and T2. Children with 22q11DS also showed significantly greater social-behavioral difficulties and psychiatric symptoms, and were more likely to meet criteria for psychiatric disorders at both time points. In evaluating change over time from T1 to T2, the 22q11DS group did not show significant changes in psychoeducational or psychiatric outcomes relative to the controls, however, lack of expected age-related gains in attention regulation were noted. Within the 22q11DS group, an increase in the Attenuated Prodrome for Schizophrenia (number of psychiatric symptoms) was noted from T1 to T2 and four children with 22q11DS met criteria for Psychosis for the first time. Predictors at T1 that uncovered psychopathology symptoms at T2 included full-scale IQ, externalizing symptoms, and problem social behaviors. Overall, younger adolescent and preadolescent children with 22q11DS in this study exhibited slowed growth in attention regulation, with an increase in subclinical symptoms of schizophrenia, suggestive of increasing impairments in domains that are relevant to the high risk of Schizophrenia. Early predictors of later psychopathology included both cognitive and behavioral abnormalities. These findings begin to elucidate the trajectory of changes in psychopathology in children with 22q11DS in the years leading up to the onset of major psychiatric illnesses.
journal_name
Res Dev Disabiljournal_title
Research in developmental disabilitiesauthors
Hooper SR,Curtiss K,Schoch K,Keshavan MS,Allen A,Shashi Vdoi
10.1016/j.ridd.2012.12.003subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1758-69issue
5eissn
0891-4222issn
1873-3379pii
S0891-4222(12)00323-Xjournal_volume
34pub_type
杂志文章abstract:BACKGROUND:Only a small number of longitudinal studies have been conducted to assess the literacy skills of children with hearing impairment. The results of these studies are inconsistent with regard to the importance of phonology in reading acquisition as is the case in studies with hearing children. Colin, Magnan, Ec...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2013.02.001
更新日期:2013-05-01 00:00:00
abstract::The literature on the association between behavioural and emotional problems and ageing in adults with Down syndrome (DS) without dementia is limited and has generally not reported on a wide range of behavioural and emotional problems. This research aimed to extend the field by examining the associations between age a...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2014.04.010
更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Research in developmental disabilities
pub_type: 临床试验,杂志文章
doi:10.1016/j.ridd.2011.03.006
更新日期:2011-09-01 00:00:00
abstract::The latest researchers have employed software technology to turn gyration air mice into a high performance limb detector to detect specific limb movement, and to further collaborate using the preferred environmental stimulation to help people with disabilities to suppress unwanted behaviors or habits and to reward goo...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2013.09.001
更新日期:2013-12-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2009.08.004
更新日期:2010-01-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章,评审
doi:10.1016/j.ridd.2013.09.043
更新日期:2014-01-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2009.09.002
更新日期:2010-01-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/s0891-4222(96)00031-5
更新日期:1996-11-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2012.03.025
更新日期:2012-09-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章,评审
doi:10.1016/j.ridd.2012.02.009
更新日期:2012-07-01 00:00:00
abstract::This study provided that people with multiple disabilities can have a collaborative working chance in computer operations through an Enhanced Multiple Cursor Dynamic Pointing Assistive Program (EMCDPAP, a new kind of software that replaces the standard mouse driver, changes a mouse wheel into a thumb/finger poke detec...
journal_title:Research in developmental disabilities
pub_type: 临床试验,杂志文章
doi:10.1016/j.ridd.2012.07.016
更新日期:2013-01-01 00:00:00
abstract::The objectives of this study were to describe the nature of the attention deficits in children with Neurofibromatosis type 1 (NF1) in comparison with typically developing (TD) children, using the Virtual Classroom (VC), and to assess the utility of this instrument for detecting attention deficits. Twenty-nine NF1 chil...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2011.06.014
更新日期:2011-11-01 00:00:00
abstract::Children with multiple handicaps, including cerebral palsy (CP), often lose or regress in their functional ability through adolescence and adulthood. The purpose of this study was to examine functional and psychological changes in children, adolescents and young adults with CP. A retrospective chart review and a prosp...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2006.03.005
更新日期:2007-07-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2014.03.034
更新日期:2014-07-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2011.05.026
更新日期:2011-11-01 00:00:00
abstract:AIMS:This pilot study investigated perceptual and electrophysiological characteristics of dyslexic children, and evaluated the immediate and prolonged effect of visual perceptual training on these characteristics in these children. METHODS AND PROCEDURES:Seven dyslexic children and seven controls aged 7-8 years were r...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2018.06.008
更新日期:2018-09-01 00:00:00
abstract::For individuals with visual impairments, auditory spatial localization is one of the most important features to navigate in the environment. Many works suggest that blind adults show similar or even enhanced performance for localization of auditory cues compared to sighted adults (Collignon, Voss, Lassonde, & Lepore, ...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2016.02.019
更新日期:2016-06-01 00:00:00
abstract::The effectiveness and efficiency (training trials and training errors through criterion) of stimulus fading, stimulus shaping, time delay, and a feedback only procedure were compared in teaching three adults with moderate developmental delays sight words encountered in activities of daily living. In Experiment 1, the ...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/0891-4222(93)90015-c
更新日期:1993-03-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2011.09.004
更新日期:2012-01-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2007.05.001
更新日期:2008-05-01 00:00:00
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journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2018.07.001
更新日期:2018-09-01 00:00:00
abstract::Individuals with Down syndrome (DS) exhibit reduced aerobic capacity with reduced peak heart rate (HRpeak). This condition is often coexistent with higher level of obesity compared to individuals without DS. The purpose of this study is to investigate the effects of obesity and Down syndrome (DS) on peak heart rate (H...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2014.10.002
更新日期:2015-01-01 00:00:00
abstract::Toys help children in mastering developmental tasks. This study investigated toy effect on children with developmental disabilities as they engage in using ordinary and adaptive toys. A single-subject design was used to identify the effects on their toy play abilities. Differences in toy effects between playing ordina...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2007.08.004
更新日期:2008-09-01 00:00:00
abstract::The purpose of this study was to identify determinants of self-determined behaviors of young children with cerebral palsy. The participants were 429 children (56% boys, 18-60 months) and their parents. Structural equation modeling was used to test two models of self-determined behaviors, one for children with walking ...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2013.10.004
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The present study focused on typically developing siblings (TDS) in emerging adulthood of individuals with autism spectrum disorder (ASD) and sought insight into how gender may interact with positive and negative affects in this population. In addition, we aimed to explore the gender differences as a moderat...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2020.103829
更新日期:2021-01-01 00:00:00
abstract:AIM:The aim of this study was to systematically review the current literature to determine the impact of strength training on skeletal muscle morphology and architecture in individuals aged 4-20 years with spastic type cerebral palsy. METHODS:A comprehensive search for randomised and non-randomised controlled trials, ...
journal_title:Research in developmental disabilities
pub_type: 杂志文章,评审
doi:10.1016/j.ridd.2016.06.003
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:The aims of this study were to adapt the Gross Motor Function Measure-88 (GMFM-88) for children with Cerebral Palsy (CP) and Cerebral Visual Impairment (CVI) and to determine the test-retest and interobserver reliability of the adapted version. METHOD:Sixteen paediatric physical therapists familiar with CVI pa...
journal_title:Research in developmental disabilities
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.ridd.2015.07.013
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Current research suggests that supported employment for people with developmental disabilities offers significantly higher rates of employment, personal satisfaction, and employer satisfaction. This study focuses on tensions experienced by employment support professionals while working with employers regarding ...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2020.103603
更新日期:2020-02-08 00:00:00
abstract::Facial expression processing and the attribution of facial emotions to a context were investigated in adults with Down syndrome (DS) in two experiments. Their performances were compared with those of a child control group matched for receptive vocabulary. The ability to process faces without emotional content was cont...
journal_title:Research in developmental disabilities
pub_type: 杂志文章
doi:10.1016/j.ridd.2009.02.004
更新日期:2009-09-01 00:00:00