[Flicker stimulation induces retinal vasodilation in man].

Abstract:

BACKGROUND:Previous studies have demonstrated, in the cat, a vasodilatation of retinal vessels in response to neuronal activity induced by diffuse luminance flicker. The aim of this study was to determine whether a similar diameter variation is detectable in humans. MATERIALS AND METHODS:Nine normal subjects were exposed to 1 min of sinusoidally varying diffuse luminance flicker (10 Hz, 30 degrees around optic nerve head). Monochromatic fundus pictures before and after the stimulation were taken. The diameter of retinal arteries and veins was measured on the digitised photographs with the NIH-Image software and an own algorythm. RESULTS:The diameter immediately after flicker was significantly larger than the pre-stimulus diameter by 4.2 +/- 2.2% (p < 0.014) (mean +/- SD) for the retinal arteries and 2.7 +/- 1.7% (p < 0.001) for the retinal veins. Six seconds after cessation of the flicker, arterial diameter was not significantly different from that of pre-flicker value. CONCLUSIONS:Diffuse luminance flicker induces an increase in retinal vessel diameter. This suggest that retinal blood flow is coupled with neuronal activity as previously evidenced by the blue field simulation technique in the macula.

journal_name

Klin Monbl Augenheilkd

authors

Formaz F,Riva CE,Geiser MH,Petrig BL

doi

10.1055/s-2008-1034897

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

326-9

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

212

pub_type

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