Abstract:
BACKGROUND:To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis. HISTORY AND SIGNS:Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 200 mg twice daily to observe the clinical response in the treatment of fungal keratitis. THERAPY AND OUTCOME:The mean age of the patients was 51 years and the average treatment duration was 6 weeks. The corneal inflammation in these three patients was eliminated by oral voriconazole only. CONCLUSIONS:This is the first reported case of oral voriconazole only as a treatment for fungal keratitis. We found that oral voriconazole has a significant clinical effect on the treatment of fungal keratitis. HINTERGRUND:Berichterstattung über die klinische Wirkung von oralem Voriconazol zur Behandlung von Pilzkeratitis. ANAMNESE UND BEFUNDE:Insgesamt wurden 3 konsekutive Patienten (1 Frau, 2 Männer) mit gesicherter Pilzkeratitis (1 mit Mucoraceae, 1 mit Aspergillus, 1 mit Fusarium) in diese Studie eingeschlossen. Die Patienten wurden 2 × täglich mit 200 mg oralem Voriconazol behandelt, um das klinische Ansprechen bei der Behandlung der Pilzkeratitis zu beobachten. THERAPIE UND VERLAUF:Das Durchschnittsalter der Patienten betrug 51 Jahre und die durchschnittliche Behandlungsdauer 6 Wochen. Die Hornhautentzündung bei diesen 3 Patienten wurde nur durch orales Voriconazol beseitigt. SCHLUSSFOLGERUNGEN:Dies ist der erste Bericht, bei dem nur orales Voriconazol zur Behandlung von Pilzkeratitis verwendet wird. Wir fanden heraus, dass orales Voriconazol einen signifikanten klinischen Effekt auf die Behandlung von Pilzkeratitis hat.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Chen D,Tan S,Zou Wdoi
10.1055/a-1268-9168subject
Has Abstractpub_date
2021-01-01 00:00:00pages
55-59issue
1eissn
0023-2165issn
1439-3999journal_volume
238pub_type
杂志文章abstract::Due to the anatomic location of the N. opticus to the brain and its embryological development as a "bulging part of the brain", a close connection between the opticoneuropathy and certain neurological diseases exists. Glaucoma is a chronic neurodegenerative disorder and many cellular and molecular mechanisms of the ch...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1360316
更新日期:2014-02-01 00:00:00
abstract::The tearing eye (epiphora) is the guiding symptome of nasolacrimal duct obstruction. Depending on the localization of stenosis, mucopurulent lacrimal discharge occurs additionally. These symptoms induce alterations of the optical system and can cause severe complications such as acute phlegmonous dacryocystitis. The g...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1283-9271
更新日期:2020-11-18 00:00:00
abstract::The biological significance of autophagy in the metabolism of visual cells is discussed. In the process of autophagy, parts of the cytoplasm including cell organelles are surrounded by membranes. This formation is called an autophagic vacuole. Then, the contents of the vacuole are degraded by enzymes. Autophagy is a w...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::To determine the influence of preoperative rubeosis iridis and active neovascularization at the fundus on surgical results, the authors analyzed a consecutive series of 85 eyes that underwent vitrectomy for diabetic tractional detachment of the macula. Minimum follow-up was 12 months. Rubeosis was present in 51%, acti...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050199
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Proliferative retinopathy is an important cause of vision loss in diabetic patients. Incomplete panretinal photocoagulation (PRP) can lead to recurrent proliferation of new vessels. PATIENTS AND METHODS:We retrospectively analysed the outcome of patients with high risk proliferative diabetic retinopathy (PD...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0035-1545795
更新日期:2015-04-01 00:00:00
abstract::A flexible silicone-rubber suturamide retention tube, the procedure of intubation and special instruments for the repair of persistent congenital nasolacrimal duct obstructions are described. The results of the treatment of 8 infants are discussed. With the exception of one functional failure, the very good results ar...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054617
更新日期:1984-10-01 00:00:00
abstract::Novel microscope-integrated OCT now allows targeted intraoperative high-resolution real-time imaging. In comparison to conventional surgical microscopes, intraoperative real-time OCT visualisation of retinal layers and vitreous body provides valuable information for surgical decision-making. In addition, simultaneous ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1193-9045
更新日期:2020-10-01 00:00:00
abstract::Brachytherapy with 106Ru/106Rh necessitates protracted irradiation because the applicators have to be sutured to the sclera. Protracted radiotherapy causes more intensive damage in tumor cells with increased metabolism and a higher mitosis rate than in normal tissue. Beta irradiation of rabbit eyes with 0.258-0.231 Gy...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050770
更新日期:1986-08-01 00:00:00
abstract::Experimental occlusion of a retinal vein leads to retinopathy in the affected drainage area. In some cases the formation of ischemic regions, where the retina is completely destroyed, is typical for the development of this retinopathy. Laser photocoagulation restores the physiological preretinal oxygen pressure in the...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050970
更新日期:1985-06-01 00:00:00
abstract::Conjunctivitis is a frequent disease mostly caused by infections. In the case of a single-sided manifestation and additional resistance to anti-infective therapy a widespread differential diagnosis has to be considered. The case report of a 41-year-old patient suffering from unilateral persistent conjunctivitis is pre...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1027457
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Our study compares the biomechanical properties of the cornea in patients with long-term pre-existing (for at least 10 years) systemic sclerosis (SSc) with those of healthy suspects. MATERIAL/METHODS:The examination was performed in 14 systemic SSc patients and 38 healthy volunteers. Non-invasive assessme...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0043-125078
更新日期:2019-06-01 00:00:00
abstract::In two groups of patients with two different posterior chamber intraocular lenses, very different correlations were found between postoperative and calculated anterior chamber depth, and between postoperative anterior chamber depth and axial length. Since it has long been known that there are positive correlations bet...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046396
更新日期:1989-06-01 00:00:00
abstract::Corneal topographs that measure the anterior and posterior corneal surface with optical methods need a clear cornea for precise measurements. Opacities cause artifacts in the corneal thickness (with measurements usually being too thin) and corneal curvatures. This is important to know as certain pathologies may repeat...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0032-1327956
更新日期:2012-12-01 00:00:00
abstract::A report is given on seventeen cases of spontaneous regression of diabetic retinopathy. The diabetes became manifest, without exception, at an early age, particularly in childhood. Regression came on slowly and inconspicuously, retinopathy disappearing completely in two thirds of the cases. Of the other forms of diabe...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:The potential impact of coagulation abnormalities on retinal vascular occlusive diseases, individually and in combination with cardiovascular risk factors, remains unclear. PATIENTS AND METHODS:In a prospective case-control study a cohort of 74 young patients with central, hemicentral or branch retinal vein...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0028-1109195
更新日期:2009-09-01 00:00:00
abstract::A report is given on three patients who noticed an acute deterioration of visual acuity after a sojourn at 5000 altitude caused by retinal hemorrhages. We documented both the ophthalmological examinations such as visual acuity, fundus, perimetry and fluorescence-angiography and the systemic results. During the period ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::In 300 cases the effectiveness of the long-acting anesthetic Meaverin-ultra for retrobulbar anesthesia was systematically investigated. The duration of analgesis and immobilisation for the globe as well as for the eyelids runs over hours; they are considerabley more effective than with other common local anesthetics s...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
abstract:PURPOSE:Corneal ulcer is a very rare clinical manifestation in hereditary familial amyloidosis of the Portuguese type, from which only one case has been reported previously. The case of a 35-year-old man illustrates the diagnostic findings and the difficulties encountered in understanding the physiopathology of such a ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035238
更新日期:1996-05-01 00:00:00
abstract::On the basis of a number of examples the authors describe specific glaucomas which have often reached their final stages by the time the patients are referred to the clinic. They include sub-acute and chronic angle-closure glaucoma, pseudoexfoliation syndrome, and pigmentary glaucoma. An unpleasant feature of these gl...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046389
更新日期:1989-05-01 00:00:00
abstract::Within a period of 14 months 73 patients with idiopathic blepharospasm which could not be treated satisfactorily by any other form of therapy were treated by injections of botulin toxin. In 55 cases the follow-up period was sufficiently long to permit an evaluation. Thirty-five patients were temporarily completely fre...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050804
更新日期:1986-10-01 00:00:00
abstract::The authors report on the possibilities for examination of the stereoscopic vision at 2 or 4 meters by the phase-difference-haploscope. Besides a gross-qualitative test, methods of estmating realdepth acuity are described. There is a great variability of test-conditions for special scientific problems. During the rout...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-09-01 00:00:00
abstract::Three hundred twenty-three eyes enucleated because of intraocular tumor were studied. The microscopic features were compared with survival data from 6 to 21 years after surgery, thus permitting the prognostic value of certain findings to be determined. Of the tumors, 299 were malignant melanomas of the choroid (262 ey...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055271
更新日期:1982-12-01 00:00:00
abstract::Four serologically-proved cases of intraocular toxocara infections are demonstrated. Three different manifestations in the following way were found: 1. Solitary granuloma on the posterior pole (2 patients). 2. Anterior and posterior uveitis of both eyes with granuloma near the ora (1 patient). 3. Iridocyclitis of both...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-12-01 00:00:00
abstract::Medium and long term results of trabeculotomy and goniotomy operations for primary congenital glaucomas treated in Lausanne between 1965 and 1990 were studied retrospectively. Parameters evaluated were intraocular pressure (IOP) and final visual acuity (VA). Data on IOP were available for 38 eyes. 66% underwent trabec...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045775
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Computer programmes for visual stimulation may give new impulses to the field of amblyopia treatment by offering an option to shift the apparative visual training into the domestic sphere. Regarding this aspect we report on a placebo controlled study on a newly developed vision training consisting of a backg...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:10.1055/s-2001-14921
更新日期:2001-04-01 00:00:00
abstract::The unusual combination of bilateral occipital calcification in the area of the calcarine fissure, optic atrophy and macular changes was seen in a four-year-old girl. Corrected visual acuity was R 0.1 and L 0.5. There was irregular concentric narrowing of the visual fields. The ERG was normal, but the latencies of vis...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050092
更新日期:1988-02-01 00:00:00
abstract::Oral doses of propranolol and metoprolol were tested on 24 patients without glaucoma. The aim of this study was to compare the decrease in intraocular pressure in normal eyes following a single oral dose of propranolol or metoprolol. A statistically significant decrease in IOP was noticed, but no difference was seen b...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The use of virtual reality (VR) has gained increasing interest for the acquirement of ophthalmosurgical skills outside the operating room and is thereby increasing patients' safety. The aim of this study was to evaluate trainees' acceptance of VR for assessment and training during several Drylabs with an oph...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0028-1109383
更新日期:2009-08-01 00:00:00
abstract::A rare case of mucopolysaccharidosis, i.e., Morquio's disease with spondyloepiphyseal dysplasia, corneal clouding, normal intelligence, and deficiency of beta-galactosidase activity is described. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054350
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:In strabismus surgery the challenge is the preoperative determination of the surgical dosage. We assessed the long-term follow-up after strabismus surgery for exodeviations and evaluated the employed dosage. PATIENTS AND METHODS:We present a study of 53 consecutive patients who underwent surgery for exodevi...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:10.1055/s-0028-1109265
更新日期:2009-04-01 00:00:00