Treating Fungal Keratitis with Oral Voriconazole Only: A Case Series.

Abstract:

BACKGROUND:To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis. HISTORY AND SIGNS:Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 200 mg twice daily to observe the clinical response in the treatment of fungal keratitis. THERAPY AND OUTCOME:The mean age of the patients was 51 years and the average treatment duration was 6 weeks. The corneal inflammation in these three patients was eliminated by oral voriconazole only. CONCLUSIONS:This is the first reported case of oral voriconazole only as a treatment for fungal keratitis. We found that oral voriconazole has a significant clinical effect on the treatment of fungal keratitis. HINTERGRUND:Berichterstattung über die klinische Wirkung von oralem Voriconazol zur Behandlung von Pilzkeratitis. ANAMNESE UND BEFUNDE:Insgesamt wurden 3 konsekutive Patienten (1 Frau, 2 Männer) mit gesicherter Pilzkeratitis (1 mit Mucoraceae, 1 mit Aspergillus, 1 mit Fusarium) in diese Studie eingeschlossen. Die Patienten wurden 2 × täglich mit 200 mg oralem Voriconazol behandelt, um das klinische Ansprechen bei der Behandlung der Pilzkeratitis zu beobachten. THERAPIE UND VERLAUF:Das Durchschnittsalter der Patienten betrug 51 Jahre und die durchschnittliche Behandlungsdauer 6 Wochen. Die Hornhautentzündung bei diesen 3 Patienten wurde nur durch orales Voriconazol beseitigt. SCHLUSSFOLGERUNGEN:Dies ist der erste Bericht, bei dem nur orales Voriconazol zur Behandlung von Pilzkeratitis verwendet wird. Wir fanden heraus, dass orales Voriconazol einen signifikanten klinischen Effekt auf die Behandlung von Pilzkeratitis hat.

journal_name

Klin Monbl Augenheilkd

authors

Chen D,Tan S,Zou W

doi

10.1055/a-1268-9168

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

55-59

issue

1

eissn

0023-2165

issn

1439-3999

journal_volume

238

pub_type

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