Periodontal conditions and salivary immunoglobulins in individuals with Down syndrome.

Abstract:

:Periodontal conditions and salivary levels of immunoglobulins sIgA, IgM, and IgG subclass distribution and albumin, quantified by enzyme-linked immunosorbent assay, were determined in 20 patients with Down syndrome and 19 healthy controls. Gingival inflammation was more extensive (P < 0.05) among Down syndrome subjects compared to controls as well as the occurrence of periodontal pockets (> 4 mm) (P < 0.05). The immunoglobulin levels of sIgA, IgM, the sum of IgG subclasses, and the concentration of albumin did not differ significantly between the 2 groups. However, the proportion of IgG1 expressed as percentage of the sum of total IgG was significantly higher (P < 0.01) in the Down syndrome group compared to controls. On the contrary, the proportion of IgG2, IgG3, and IgG4 subclasses in saliva did not differ between the 2 groups. The results indicate an altered distribution of IgG subclasses in saliva, with a higher proportion of IgG1 in Down syndrome individuals compared to controls.

journal_name

J Periodontol

authors

Barr-Agholme M,Dahllöf G,Modéer T,Engström PE,Engström GN

doi

10.1902/jop.1998.69.10.1119

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

1119-23

issue

10

eissn

0022-3492

issn

1943-3670

journal_volume

69

pub_type

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