Usefulness of serial carcinoembryonic antigen (CEA) determinations in monitoring chemotherapy.

Abstract:

:Serial carcinoembryonic antigen (CEA) levels were measured during chemotherapy for metastatic cancer in 94 patients. Criteria for chemotherapy responses were those used by the Central Oncology Group. Patients were classified according to changes in CEA levels and response to chemotherapy. Four categories represented a positive correlation: (1) increasing abnormal CEA with progressing disease, (2) decreasing abnormal CEA with disease regression, (3) unchanged abnormal CEA with stable disease, (4) change from normal to abnormal CEA with progressive disease. Positive correlation of serial CEA levels with clinical responses occurred in 71% of patients with GI cancer, 51% with breast cancer, 42% with sarcoma, 50% with respiratory cancer, and 25% with melanoma. These data indicate that serial CEA determinations may be of value as an additional parameter of response to chemotherapy in gastrointestinal cancer.

journal_name

South Med J

journal_title

Southern medical journal

authors

Young VL,Kashmiri R,Hazen ZR,Meeker WR Jr

doi

10.1097/00007611-197610000-00008

subject

Has Abstract

pub_date

1976-10-01 00:00:00

pages

1274-6

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

69

pub_type

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