Abstract:
:Serial carcinoembryonic antigen (CEA) levels were measured during chemotherapy for metastatic cancer in 94 patients. Criteria for chemotherapy responses were those used by the Central Oncology Group. Patients were classified according to changes in CEA levels and response to chemotherapy. Four categories represented a positive correlation: (1) increasing abnormal CEA with progressing disease, (2) decreasing abnormal CEA with disease regression, (3) unchanged abnormal CEA with stable disease, (4) change from normal to abnormal CEA with progressive disease. Positive correlation of serial CEA levels with clinical responses occurred in 71% of patients with GI cancer, 51% with breast cancer, 42% with sarcoma, 50% with respiratory cancer, and 25% with melanoma. These data indicate that serial CEA determinations may be of value as an additional parameter of response to chemotherapy in gastrointestinal cancer.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Young VL,Kashmiri R,Hazen ZR,Meeker WR Jrdoi
10.1097/00007611-197610000-00008subject
Has Abstractpub_date
1976-10-01 00:00:00pages
1274-6issue
10eissn
0038-4348issn
1541-8243journal_volume
69pub_type
杂志文章abstract::Human immunodeficiency virus (HIV) has caused resurgence in tuberculosis (TB) worldwide. HIV-TB coinfected individuals are at increased risk for complications of TB and HIV treatment, such as adverse drug reactions and immune reconstitution syndrome. A 17-year-old male with HIV-TB coinfection, who developed cardiac ta...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181684b92
更新日期:2008-05-01 00:00:00
abstract::Topotecan HCl is an antitumor drug exhibiting topoisomerase 1-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature. To date, only one...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-200407000-00018
更新日期:2004-07-01 00:00:00
abstract::A case of SLE with the unique association of gastric polyps and vasculitis is reported. Gastrointestinal symptoms, surgical indications, and complications of SLE with gastrointestinal involvement are reviewed. The unusual patterns of ileus or lupus peritonitis secondary to mesenteric vasculitis must be differentiated ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::Variant angina pectoris, usually not precipitated by exertion or emotional stress, often is more severe and lasts longer than classic angina. The pain tends to recur at about the same time each day. Arrhythmias, usually ventricular, occur in about 50% of cases during the peak of pain. Electrocardiograms show a charact...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-197603000-00034
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Nontubercular mycobacteria (NTM) are increasingly recognized to cause lung disease in immunocompetent patients. We studied the occurrence of pulmonary infection due to NTM in immunocompetent men. METHODS:We retrospectively analyzed all sputum mycobacterial cultures at our institution over a 5-year period. C...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::Maffucci's syndrome in a 17-year-old girl is reported. Since the entity was first described in 1881 by Maffucci, 105 additional cases have been recorded. Several series have reported a small but significant percentage of cases (up to 18%) with malignant change. Our case, although not particularly unique in comparison ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197804000-00033
更新日期:1978-04-01 00:00:00
abstract::The University of Virginia Department of Medicine has reorganized its adult diabetic ambulatory care program to provide optimal primary care and subspecialty services. This new program, the Diabetes Consult Service of the University Medical Associates, is organized to provide primary care by a single physician in addi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Infection with Mycobacterium kansasii in patients with acquired immunodeficiency syndrome usually involves the lung or disseminated infection. We report a case of infection with M kansasii confined to the adrenal gland and possibly to an adjacent vertebral body that presented as a fever of undetermined origin. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199810000-00019
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:Peripheral vascular disease (PVD) is underdiagnosed in primary care due to the absence of established criteria to warrant diagnostic testing. Our goal was to establish a risk factor hierarchy to enable earlier diagnosis of PVD. METHODS:Data sets of 142 patients with abnormal ankle brachial indices (ABI) wer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000141303.47034.46
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:Anemia, either chronic or newly developed in the hospital as a result of underlying disease and/or phlebotomy, is seen commonly among general medical inpatients, and its impact on the quality and efficiency of care is unknown. METHODS:This study investigated the relation among hemoglobin level, length of st...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318290f930
更新日期:2013-05-01 00:00:00
abstract::Despite the remarkably low mortality from poisonous snakebites in the United States during the past few years, there has been little improvement in preventing deformities of digits. Using a retrospective study of 207 cases of poisonous snakebite, I present a method that has been highly successful in avoiding deformiti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198506000-00020
更新日期:1985-06-01 00:00:00
abstract::A patient with pathologically proven acrometastasis of his left thumb presented 3 months after esophagectomy for esophageal squamous cell carcinoma. Interestingly, there was indeed a faint uptake in his left thumb that was initially considered an artifact in the whole body bone scan taken before esophagectomy. Physici...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31817bf9be
更新日期:2008-11-01 00:00:00
abstract::A case of nephrotic syndrome due to minimal change renal disease was associated with minimally symptomatic nodular sclerosing Hodgkin's disease in a 15-year-old girl. Although minimal renal disease is the most frequently described biopsy finding in this paraneoplastic syndrome, the combination of nodular sclerosing Ho...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198205000-00027
更新日期:1982-05-01 00:00:00
abstract::The diagnosis of sarcoidosis is best established when there is evidence of granulomatous involvement in two or more organs. Three patients with unusual cutaneous manifestations of sarcoidosis, including palmar and follicular lesions, nonscarring alopecia, and widespread plaque or erythrodermic sarcoidosis, are reporte...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197706000-00009
更新日期:1977-06-01 00:00:00
abstract:OBJECTIVE:Few tests of functional motor behavior are useful for rapidly screening people for lower extremity peripheral neuropathy. The goal of this study was to improve the widely used tandem walking (TW) test. METHODS:We tested "normal" (control) adult and ambulatory patients with peripheral neuropathy (PN) with the...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/SMJ.0000000000000009
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The use of lasers has assumed an increasingly important role in the treatment of a variety of cutaneous lesions over the past few decades. Because of their effectiveness, physicians from a variety of specialties have incorporated lasers into their practices. Unfortunately, widespread availability of lasers a...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199809000-00002
更新日期:1998-09-01 00:00:00
abstract::A retrospective review of all admissions to the University of Kentucky Medical Center from 1977 to 1987 revealed six persons in whom splenic vein thrombosis could be documented. The patients had either upper gastrointestinal bleeding from gastroesophageal varices or abdominal pain. Pancreatic disease was present in fi...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199004000-00014
更新日期:1990-04-01 00:00:00
abstract::Seven adults with acute leukemia had a clinical and radiologic diagnosis of neutropenic enterocolitis. Six of the seven patients had granulocyte counts less than 500/microliter. All seven patients responded to intensive medical therapy, including bowel rest, broad spectrum antibiotics, and white blood cell transfusion...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198710000-00008
更新日期:1987-10-01 00:00:00
abstract::Sodium fluoride has clearly been shown to have pronounced effects on the skeleton, probably more than any other currently available therapeutic agent. Unfortunately, these effects appear to be both beneficial and potentially toxic at the same time. A more clear understanding is needed of the basic mechanisms whereby t...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199208001-00007
更新日期:1992-08-01 00:00:00
abstract::A patient with pancytopenia, severe sensory neuropathy, and a six-year history of excessive vitamin intake showed portal hypertension on evaluation. A liver biopsy revealed hypervitaminosis A. His sensory findings were characteristic of a recently described syndrome of sensory neuropathy secondary to megadoses of vita...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198402000-00018
更新日期:1984-02-01 00:00:00
abstract::A review of the available clinical and pathologic information suggests that the biologic behavior of prostatic carcinoma can be characterized by one of three different tumor-growth kinetic curves. Failure to identify the biologic potential of the tumor, as indicated by the pattern of its growth curve, can result in in...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::Nitrogen, derived from breakdown of dietary amino acids as ammonia, is normally converted to urea and excreted. Impairment in the conversion process (called the urea cycle) can occur, either as a consequence of primary genetic defects or through secondary suppression of enzyme activity. Either process results in hyper...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199307000-00004
更新日期:1993-07-01 00:00:00
abstract::Chest pain is a frequent patient complaint that requires a careful history and physical examination to determine its cause. Cardiac and esophageal causes of chest pain are common, but musculoskeletal disorders such as Tietze's syndrome, chest wall pain syndromes, fibrositis, inflammatory arthritic conditions, cervical...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198801000-00014
更新日期:1988-01-01 00:00:00
abstract::A 63-year-old male patient with a history of bipolar I disorder presented to the emergency department in an acutely psychotic state. The patient had just returned from vacation in a malarial high-risk area and, as a result, had taken five weekly doses of mefloquine for prophylaxis. The patient's bipolar disorder was b...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318167a9e2
更新日期:2008-05-01 00:00:00
abstract::With the advent of ultrasonography, perinephric fluid collection can be easily diagnosed and confirmed by fine needle aspiration. In the past these cases sometimes went undiagnosed for several months. We did fine needle aspiration under the guidance of ultrasonography in 16 patients without complications. The aspirant...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198506000-00018
更新日期:1985-06-01 00:00:00
abstract::The aim of this project was to review the course of infants referred for consideration of extracorporeal membrane oxygenation (ECMO) to identify maximal ventilator settings that, when exceeded, did not provide clinical benefit to the patient. These settings might then be used in defining failure of conventional mechan...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199706000-00009
更新日期:1997-06-01 00:00:00
abstract::The rapid increase in the use of helicopters for hospital transport during the 1980s is the culmination of several hundred years of military medical innovation. Mass battefield casualties spurred both technologic and medical changes necessary for today's sophisticated helicopter systems in use worldwide, particularly ...
journal_title:Southern medical journal
pub_type: 历史文章,杂志文章
doi:10.1097/00007611-198907000-00022
更新日期:1989-07-01 00:00:00
abstract::We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving "standard" doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and cl...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199701000-00007
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Insurance status has the potential to play a significant role in an individual's health care by affecting the time of diagnosis and the treatment options used. Our study reviewed insurance status as a determinant of the time of a breast cancer diagnosis as well as the surgical treatment options offered. MET...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000281
更新日期:2015-05-01 00:00:00
abstract::An elderly man with previous tuberculosis exsanguinated from esophageal rupture of an atherosclerotic thoracic aneurysm. Because the patient refused angiography, the source of bleeding was discovered only at autopsy. Selected clinical and pathologic aspects of the case are discussed in relation to the different causes...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197907000-00042
更新日期:1979-07-01 00:00:00