Hyperammonemia: the silent killer.

Abstract:

:Nitrogen, derived from breakdown of dietary amino acids as ammonia, is normally converted to urea and excreted. Impairment in the conversion process (called the urea cycle) can occur, either as a consequence of primary genetic defects or through secondary suppression of enzyme activity. Either process results in hyperammonemia, producing a clinical picture virtually indistinguishable from many other diseases of infancy. Moreover, there is no way to detect hyperammonemia except to measure the blood ammonia level. Thus, the capability to do so is a minimum standard of care in any hospital setting. Use of commonly obtained laboratory studies is discussed in the context of rapid, presumptive diagnosis of the causes of hyperammonemia.

journal_name

South Med J

journal_title

Southern medical journal

authors

Miga DE,Roth KS

doi

10.1097/00007611-199307000-00004

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

742-7

issue

7

eissn

0038-4348

issn

1541-8243

journal_volume

86

pub_type

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