Abstract:
:Sodium fluoride has clearly been shown to have pronounced effects on the skeleton, probably more than any other currently available therapeutic agent. Unfortunately, these effects appear to be both beneficial and potentially toxic at the same time. A more clear understanding is needed of the basic mechanisms whereby these effects (both beneficial and detrimental) are exerted. When such data are forthcoming, it may be possible to modify the therapeutic use of fluoride in osteoporosis and other brittle bone diseases such that the beneficial effects outweigh the toxic effects much more completely than is currently the case. Until such time, and despite thirty years of meaningful clinical investigation, we must conclude that sodium fluoride has no role in clinical medicine outside the confines of properly conducted clinical research studies.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Kleerekoper M,Balena Rdoi
10.1097/00007611-199208001-00007subject
Has Abstractpub_date
1992-08-01 00:00:00pages
2S34-42issue
8eissn
0038-4348issn
1541-8243journal_volume
85pub_type
杂志文章,评审abstract:OBJECTIVE:To deliver effective care, healthcare systems should understand patients' preferences for weight management across a spectrum of needs. Our objective was to describe patients' perceptions of what helps or hinders weight loss and maintenance. METHODS:Semistructured interviews were conducted with patients who ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001196
更新日期:2021-01-01 00:00:00
abstract::A 32-year-old farmer had signs and symptoms of dinitrophenol poisoning after crop spraying with a herbicide containing derivatives of 2,4-dinitrophenol. Dinitrophenol causes toxicity by the uncoupling of oxidative phosphorylation in the mitochondria of cells throughout the body. In man the classic syndrome consists of...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::A technic incorporating the simultaneous elevation of multiple adjacent thoracoabdominal pedicale flaps, based in opposite directions, has been successfully used on four patients with extensive degloving injuries of the hand. In all cases, the hand was later divided into individual digits. A five-year follow-up of thr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197803000-00024
更新日期:1978-03-01 00:00:00
abstract:OBJECTIVES:This study evaluated the role of ankle-brachial index (ABI) as an effective screening test of coronary artery disease (CAD) in the Hispanic population. METHODS:This was an observational cross-sectional study, based on a retrospective review of the medical management of the study patients using already avail...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318189aabc
更新日期:2008-11-01 00:00:00
abstract::We reviewed the first 100 consecutive patients treated with extracorporeal shock wave lithotripsy (ESWL) at one institution. A total of 115 treatments were delivered to 58 men and 42 women. Patients with calculi of various sizes were treated and compared for (1) length of hospitalization, (2) ancillary procedures, (3)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198801000-00010
更新日期:1988-01-01 00:00:00
abstract::We have described a 47-year-old white woman who had spontaneous E coli K1 meningitis after acquiring an E coli K1 urinary tract infection with associated sepsis. The patient's symptoms consisted only of severe headache, fever, and malaise. She had no meningeal or focal neurologic signs, and the CSF did not contain whi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198309000-00044
更新日期:1983-09-01 00:00:00
abstract::In 1979 more than 54% of women with children less than 18 years old were in the labor force. The purpose of this study was to study the attitudes of pediatricians toward maternal employment and substitute child care arrangements. To survey their attitudes toward maternal employment and substitute child care, we sent a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198406000-00016
更新日期:1984-06-01 00:00:00
abstract::A leg ulcer in a 52-year-old renal transplant patient yielded foamy histiocytes containing acid-fast bacilli subsequently identified as a Runyon group III Mycobacterium. Skin infection with these organisms is unusual, and the histologic appearance in this case suggested lepromatous leprosy. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198708000-00033
更新日期:1987-08-01 00:00:00
abstract::Extraskeletal dedifferentiated chondrosarcomas (DC) are uncommon tumors that predominantly occur in the head and neck. Herein, we describe a case of pulmonary DC detected in a patient with systemic sclerosis and presenting with a symptomatic large pleural effusion and a pulmonary lobar consolidation on chest imaging. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181ad6236
更新日期:2009-08-01 00:00:00
abstract::The predictability of a method of determining serum digoxin concentration was assessed in a retrospective study of 35 hospitalized patients taking digoxin orally for maintenance therapy. Simple pharmacokinetic expressions were used to estimate digoxin concentration. Clinically, the mean measured digoxin concentration ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198403000-00016
更新日期:1984-03-01 00:00:00
abstract::We have described a case of thrombocytopenic purpura caused by methyldopa. A methyldopa-dependent antiplatelet antibody as the mechanism of the patient's thrombopenia was suggested by a positive clot retraction inhibition test. This simple in vitro test should be done more often in suspected cases of drug-induced thro...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198203000-00036
更新日期:1982-03-01 00:00:00
abstract::The ultimate evolution of our case and its atypical features of unilateral blindness, bilateral involvement, and extensive involvement of the trigeminal nerve revealed the pathogenesis of this case of alternating painful ophthalmoplegia resembling the Tolosa-Hunt syndrome to be that of a parasellar pituitary adenoma. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198010000-00033
更新日期:1980-10-01 00:00:00
abstract::Since 1965, 330 patients have received chronic dialysis treatment at the Nashville VA Hospital. Home hemodialysis training was established in 1968, and a unique class format has been used since 1970. Despite the national trend of fewer patients beginning home dialysis each year, more than 50 percent of our patients ha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197712000-00016
更新日期:1977-12-01 00:00:00
abstract::The incidence of fatal and nonfatal pulmonary embolism (PE) was evaluated in a series of 578 patients, to quantify the suspected higher risk in cancer patients of death from massive PE when compared with patients not having cancer. PE occurred in 13% and was fatal in 8% of noncancer patients. It occurred in 17% and wa...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198007000-00005
更新日期:1980-07-01 00:00:00
abstract::From Jan 1, 1978 through Dec 31, 1983, 64 patients with epithelial ovarian tumors, frankly malignant or borderline, were managed at one institution. Nineteen patients (29.7%) were under age 40. The youngest patient was 19 years old. Nulliparity was present in 32% of this group of patients. Of these young patients, 58%...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198801000-00003
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:The blood gas analyzer (BGA) has been considered the "gold standard" for pleural fluid pH determination. METHODS:We report the various methods used to measure pleural fluid pH by 277 acute care institutions who responded to a mailed questionnaire. The techniques used included the BGA (32%), dip stick or pH ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199902000-00010
更新日期:1999-02-01 00:00:00
abstract::Sixteen patients with spinal epidural compression by metastatic small-cell lung cancer were given radiotherapy for palliation. Lower limb motor deficit was the most prominent clinical manifestation. Neurologic dysfunction was commonly present for more than 48 hours before the diagnosis of compression. Median interval ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199203000-00008
更新日期:1992-03-01 00:00:00
abstract::We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 mon...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007611-199010000-00005
更新日期:1990-10-01 00:00:00
abstract::Patients with sickle cell disease are predisposed to infection caused by Streptococcus pneumoniae. However, there has been only one published case of bacteremic pneumococcal meningitis in an adult with sickle cell anemia. We report here the cases of six adults with sickle cell disease, pneumococcal sepsis, and meningi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::As our population ages, the incidence and prevalence of Alzheimer disease (AD) will increase dramatically. A number of therapies have been investigated for the treatment and prevention of AD. Clinicians should be prepared to provide evidence-based answers to inquiries regarding AD treatment. There is insufficient evid...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.SMJ.0000166671.86815.C1
更新日期:2005-06-01 00:00:00
abstract::We have described a patient with meningitis due to Candida albicans, in whom the only identifiable risk factor was a history of intravenous amphetamine abuse. Despite intravenous therapy with 2 gm of amphotericin B and concurrent 5-fluorocytosine, symptoms, CSF pleocytosis, and hypoglycorrhachia persisted. After a bri...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198403000-00040
更新日期:1984-03-01 00:00:00
abstract::Patent ductus arteriosus (PDA) is a malady usually identified during childhood. Prompt surgical correction provides definitive therapy with long-term survival. When not corrected, PDA leads to significant morbidity and mortality, making it a rare condition in the adult population. We report the case of a 44-year-old m...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2001-03-01 00:00:00
abstract::Atomoxetine (Strattera®, Eli Lilly and Co.) is the first non-stimulant drug in the United States (US) to be approved for the treatment of attention deficit hyperactivity disorder (ADHD). In the past, physicians have been concerned about the safety of a variety of ADHD medications. As a result, non-stimulant drugs were...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318205e575
更新日期:2011-02-01 00:00:00
abstract::Recent research suggests that vitamin D may play a role in cardiovascular (CV) health. Although its exact role is still debated and is a matter of controversy, vitamin D deficiency has been linked to increased prevalence of CV risk factors and events. Factors that predispose persons with congestive heart failure (CHF)...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e318213cf6b
更新日期:2011-05-01 00:00:00
abstract::Chordomas are tumors originating from remnants of the notochord, most commonly found in the cranial and caudal regions. This is a report of the seventh intrathoracic chordoma in the world literature and the second to be reported in a woman. Histologically the physalipherous (blister-bearing) cell is characteristic of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197501000-00029
更新日期:1975-01-01 00:00:00
abstract::Since the incidence of endometrial cancer among estrogen-treated women at Wilford Hall Air Force Medical Center was not increased as reported by others, a prospective study was begun in 1975. With this data base, the cases of breast and endometrial cancer in estrogen and oral contraceptive users were reviewed. The inc...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198412000-00009
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Chlamydia is the most commonly reported infectious disease in the United States, yet many women at risk for chlamydia infection are not being tested. METHODS:We conducted a chlamydia screening study (Phase I) and retrospective medical chart review (Phase II) of 199 women from 16 to 40 years of age attending...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000053673.13882.00
更新日期:2003-09-01 00:00:00
abstract::Most of the surgical procedures proposed for the treatment of fecal incontinence associated with prolapse are associated with considerable morbidity and mortality. We used a modified Thiersch procedure with a Silastic mesh implant (Dow-Corning 501-3) on a series of 12 patients over a period of 2 1/2 years. Nine patien...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198603000-00012
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:To assess the current use of β-blockers in patients with compelling indications for use, following the acute exacerbation of chronic obstructive pulmonary disease (COPD). METHODS:We performed a multicenter retrospective observational study using data from all of the patients admitted to five institutions for...
journal_title:Southern medical journal
pub_type: 杂志文章,多中心研究
doi:10.14423/SMJ.0000000000001038
更新日期:2019-11-01 00:00:00
abstract::This report describes a 9-year-old girl with pigmented villonodular synovitis of the right knee. She presented with a chronic bloody effusion of the knee. The diagnosis of pigmented villonodular synovitis was suggested by the findings on magnetic resonance imaging and confirmed at the time of arthroscopic synovectomy....
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000104842.97001.88
更新日期:2004-01-01 00:00:00