Abstract:
BACKGROUND:Bombesin and dopamine prevent gastric injury by an unknown mechanism. Sensory neurons and endogenous prostaglandins play an important role in gastric mucosal defense. This study was designed to assess the role of these two local defense mechanisms in bombesin and dopamine-induced gastroprotection, as well as mild irritant-induced adaptive cytoprotection. METHODS:Conscious, fasted rats were given either capsaicin (125 mg/kg subcutaneously) to ablate sensory neurons or indomethacin (5 mg/kg intraperitoneally) to inhibit prostaglandin synthesis, 2 weeks and 30 minutes, respectively, before administration of bombesin (100 micrograms/kg subcutaneously), the dopamine precursor L-DOPA (25 mg/kg intraperitoneally), or the mild irritant 25% ethanol (1 mL orogastric). A 1-mL orogastric bolus of acidified ethanol (150 mmol/L HCl/50% ethanol) was given 30 minutes after pretreatment with these peptides and 15 minutes after administration of the mild irritant. Rats were killed 5 minutes later and the total area of macroscopic gastric injury quantified. RESULTS:Ablation of sensory neurons with capsaicin negated the protective actions of bombesin but failed to reverse gastroprotection by L-DOPA or 25% ethanol. Cyclooxygenase inhibition with indomethacin partially reversed bombesin and mild irritant-induced gastroprotection but did not diminish the protective actions of L-DOPA. CONCLUSIONS:Bombesin requires intact sensory neurons to exert its protective actions through a mechanism mediated, at least in part, by endogenous prostaglandins. Adaptive cytoprotection by the mild irritant 25% ethanol requires the presence of endogenous prostaglandins but not sensory neurons. L-DOPA-induced gastroprotection is independent of both local defense mechanisms.
journal_name
Surgeryjournal_title
Surgeryauthors
Mercer DW,Cross JM,Castaneda AA,Gunter JAsubject
Has Abstractpub_date
1998-11-01 00:00:00pages
864-70issue
5eissn
0039-6060issn
1532-7361pii
S0039-6060(98)70010-8journal_volume
124pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Lung contusion (LC) is a unique direct and focal insult that is considered a major risk factor for the initiation of acute lung injury and acute respiratory distress syndrome. We have shown recently that consumption of nitric oxide (due to excess superoxide) resulting in peroxynitrite formation leads to decr...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.05.023
更新日期:2013-11-01 00:00:00
abstract::To study the role of antibodies in promoting survival during gram-negative bacterial sepsis, we have developed several murine monoclonal antibodies (MAbs). One MAb (5B10) reacted in an enzyme-linked immunosorbent assay with only a single organism (Escherichia coli 0111:B4), while the other (8A1) reacted to all gram-ne...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:High-dose tacrolimus (FK506) monotherapy has significantly prolonged rat hindlimb allograft survival. With an eye toward direct clinical application, we used a large-animal extremity composite tissue allograft model to assess the antirejection efficacy and systemic toxicity of combination FK506-mycophenolate...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Recent reports demonstrate that culture of thyroid allografts before transplantation results in prolonged and sometimes indefinite survival. The loss of passenger leukocytes during organ culture was discussed as a possible reason for these findings. Recent data from a genetically defined system in the mouse demonstrat...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:The process of extrinsic reinnervation after small bowel transplantation is poorly understood. METHODS:Jejunal and ileal specimens, obtained from the dogs that underwent intestinal autotransplantation by an end-to end (E-E) or end-to-side arterial reconstruction, were analyzed at 1 (n = 7), 3 (n = 6), 6 (n ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Ischemia and reperfusion (I/R) injury is a major determinant of early graft dysfunction and long-term graft survival in small intestinal transplantation. The cavitary two-layer method (TLM) has been reported to be superior to the University of Wisconsin cold storage method (UWM) in long-term preservation of ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2003.10.013
更新日期:2004-06-01 00:00:00
abstract::A prospective study to evaluate the accuracy of early diagnosis and the efficacy of early operation for biliary tract stone disease was performed. One hundred fifty-two consecutive patients with signs and symptoms compatible with biliary colic or acute cholecystitis were admitted to the hospital and promptly evaluated...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Hyperparathyroid crisis is a rare, life-threatening condition that requires prompt removal of the involved parathyroid gland(s). This report describes a patient with hyperparathyroid crisis caused by a mediastinal parathyroid adenoma, which was localized before operation and removed at the initial operation, without n...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::A unique method of computerized fluoroscopic enhancement allows direct visualization of the entire vascular system by intravenous injection of standard contrast agents, thereby avoiding the need for arterial puncture or hospitalization. This technique has been used to satisfactorily visualize the intra- and extracrani...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Although most pancreatic neuroendocrine tumors are solid, approximately 10% are cystic. Some studies have suggested that cystic pancreatic neuroendocrine tumors are associated with a more favorable prognosis. METHODS:A retrospective review of all patients with pancreatic neuroendocrine tumors who underwent ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.04.005
更新日期:2016-09-01 00:00:00
abstract::A case of abdominal aortic aneurysm associated with renovascular hypertension in a 3-year-old boy is reported. The child was treated by resection of the aneurysm and replacement with a 12 mm polyester (Dacron) bifurcated graft. The cause of the aneurysm was not revealed by clinical and pathologic examination. In addit...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Although systems of 3-dimensional image-guided surgery are a valuable adjunct across numerous procedures, differences in organ shape between that reflected in the preoperative image data and the intraoperative state can compromise the fidelity of such guidance based on the image. In this work, we assessed in...
journal_title:Surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.surg.2017.04.020
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Osteopontin acts thru myeloid zinc finger-1 and transforming growth factor-β to drive the adoption of a cancer-associated fibroblast phenotype by local mesenchymal stem cells. Cancer-associated fibroblasts increase cancer cell stemness. METHODS:Mesenchymal stem cells were exposed to osteopontin or were cocu...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.05.042
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:This study was designed to compare the effects of hyperpolarizing versus depolarizing cardioplegic solutions on the coronary vasomotor regulation, specifically focusing on coronary myoplasmic Ca2+-myosin light chain (MLC) phosphorylation pathway and beta-adrenergic signal transduction. METHODS:With the use ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.107417
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:The most common cause of noncurative resection and recurrence is gastric cancer is peritoneal seeding. However, the results of treatment of peritoneal dissemination with chemotherapy have been poor with 5-year survival rates of 0%. METHODS:A new in vitro thermochemosensitivity test was performed on gastric ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80145-0
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Current standards for lymph node harvest in colorectal cancer surgery may be inadequate. Higher lymph node yield may improve survival, but the number of lymph nodes needed to optimize survival is unknown. The objective of this study was to examine the relationship between lymph node yield and overall surviva...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.03.027
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Improvements in outcomes after pancreatoduodenectomy (PD) have permitted more complex resections. Complete extirpation at PD may require multivisceral resection (MVR-PD); however, descriptions of morbidity of MVR-PD are limited to small, single-institution series. METHODS:The National Surgical Quality Impro...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.12.020
更新日期:2014-03-01 00:00:00
abstract::Formation of biliary calculi caused by hemobilia is rare. Including the two cases reported here, there are only a total of four in the literature. The characteristics of these calculi in vitro, on computerized tomographic scan, and cholecystography are described. The condition for the occurrence seems to be that blood...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Only annual mammography and physical examination are recommended for the post-treatment surveillance of early stage breast cancer. METHODS:We used Texas Cancer Registry-Medicare linked data (2001-2007) to identify physician visits and use of mammography, magnetic resonance imaging (MRI), computed tomography...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.04.004
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Previously we demonstrated that optimal doses of tumor-infiltrating lymphocytes (TIL) concomitant with recombinant interleukin-2 (rIL-2) effectively mediated complete tumor regression of murine 3-day pulmonary metastases. METHODS:In the present study we have investigated the contribution of the host immune ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80209-0
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:The observed to expected (O:E) mortality based on Injury Severity Scores (ISS) has been used to assess quality of trauma center (TC) care. Injuries in the elderly have increased, and these patients often have advanced directives, on occasion limiting aggressive care even for potentially survivable injuries; ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.07.065
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine if team training using a federally sponsored team training program improves operating room (OR) performance and culture. METHODS:The TeamSTEPPS program, a team training program designed and tested for health care applications, was provided to the OR staff. The training ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.07.076
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:T cells that receive T-cell antigen receptor signals but do not undergo mitosis become unresponsive to subsequent antigenic stimulation. This can be achieved by antigen presentation to T cells in the absence of critical costimulatory signals from antigen-presenting cells (APC) or in the presence of the antip...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::In patients with primary hyperparathyroidism, measurements were made of basal and stimulated levels of intact parathyroid hormone (PTH). The basal PTH values were elevated in all but six of 89 patients and provided clear separation towards normal individuals (n = 75) and patients with hypercalcemia of other origin (n ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Pathways critical for neuroblastoma cancer stem cell function are targeted by 4,19,27-triacetyl withalongolide A (WGA-TA). Because neuroblastoma cells and their cancer stem cells highly overexpress the scavenger receptor class B type 1 receptor that binds to synthetic high-density lipoprotein, we hypothesize...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.01.023
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:The experience at Loyola University Chicago was retrospectively reviewed to evaluate survival and functional outcome after single lung transplantation (SLT) and bilateral lung transplantation (BLT). METHODS:Ninety patients underwent lung transplantation at Loyola University Chicago between April 1990 and De...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Apolipoprotein J (ApoJ) is expressed after vascular injury and remodeling and may inhibit endothelial cell activation in the vascular wall. Recently, ApoJ was identified as upregulated in hyperplastic lesions after prosthetic arterial grafting. This study analyzed the effect of ApoJ on human umbilical vein e...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.115823
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Although task training on virtual reality (VR) simulators has been shown to transfer to the operating room, to date no VR curricula have been described for advanced laparoscopic procedures. The purpose of this study was to develop a proficiency-based VR technical skills curriculum for laparoscopic colorectal...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.08.005
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The objective of this study was to examine the clinicopathologic characteristics of solid pseudopapillary tumors (SPTs) of the pancreas, including the risk factors for disease recurrence and their effects on survival. METHODS:The medical records of 114 patients who underwent surgery for a pathologically con...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.11.005
更新日期:2011-05-01 00:00:00
abstract::A conical silicone rubber balloon was placed in the left hemithorax of fetal lambs and progressively inflated through an exteriorized catheter over the last trimester. Newborn lambs died of severe respiratory insufficiency, despite maximal resuscitation. The lungs were markedly hypoplastic with greatly reduced parench...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00