Abstract:
BACKGROUND:Current standards for lymph node harvest in colorectal cancer surgery may be inadequate. Higher lymph node yield may improve survival, but the number of lymph nodes needed to optimize survival is unknown. The objective of this study was to examine the relationship between lymph node yield and overall survival in patients undergoing colectomy for nonmetastatic colon adenocarcinoma. METHODS:The 2010 to 2014 National Cancer Database was queried for patients undergoing colectomy for nonmetastatic colon adenocarcinoma. Adjusted restricted cubic splines were used to model the nonlinear relationship between lymph node harvest and overall survival. Cox proportional hazard determined independent predictors of overall survival. RESULTS:A total of 261,423 patients were included. Restricted cubic splines demonstrated that the adjusted improvements in overall survival stabilized after 24 nodes. Patients were divided into: <12, 12 to 23, and ≥24 nodes. On survival analysis, patients with ≥24 nodes had better survival across all N stages compared to other groups (P < .001). Lymph node harvest ≥24 nodes was independently associated with improved overall survival compared to 12 to 23 nodes (hazard ratio 0.82; 95% confidence interval, 0.80-0.85). CONCLUSION:Lymph node harvest ≥24 nodes is associated with improved survival in colorectal cancer patients. These data may provide indirect evidence for a more extensive lymphadenectomy for colon cancer.
journal_name
Surgeryjournal_title
Surgeryauthors
Trepanier M,Erkan A,Kouyoumdjian A,Nassif G,Albert M,Monson J,Lee Ldoi
10.1016/j.surg.2019.03.027subject
Has Abstractpub_date
2019-10-01 00:00:00pages
639-647issue
4eissn
0039-6060issn
1532-7361pii
S0039-6060(19)30355-1journal_volume
166pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:The role of routine prophylactic central-neck lymph node dissection (CLND) for papillary thyroid cancer (PTC) remains controversial. We perform CLND for PTC only in patients with enlarged nodes as determined by preoperative ultrasound and intraoperative inspection and palpation. METHODS:We identified all pa...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.03.021
更新日期:2010-08-01 00:00:00
abstract::The recent surge in enthusiasm for laparoscopic surgery has created concern that abdominal insufflation with carbon dioxide produces a respiratory acidosis. This may be because of both transperitoneal gas absorption and impaired ventilation with increased dead space from elevated intraabdominal pressure. To examine th...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Aneurysms of the gastroduodenal artery are rare. Only nine cases have been reported previously. These aneurysms are extremely difficult to diagnose preoperatively. A case of ruptured gastroduodenal artery aneurysm, which was diagnosed by aortography prior to operation, is reported, and the literature is reviewed. ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract::Dr McCarthy is a fellow in cardiothoracic surgery at the University of Washington. During his general surgery training at Northwestern University, he completed a research fellowship in surgical innovation and obtained masters' degrees with a focus on health enterprise management, entrepreneurship, and innovation. ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.08.035
更新日期:2017-04-01 00:00:00
abstract::A series of 76 patients treated for carcinoma of the extrahepatic bile ducts at three Swedish hospitals during the years 1952 to 1973 was studied. The mean age of the patients was 68 years. Gallstones were found in 22 patients, whereas 11 patients had undergone cholecystectomy earlier for gallstone disease. At operati...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:The influence of diabetic therapies on myocardial substrate selection during cardiac surgery is unknown but may be important to ensure optimal surgical outcomes. We hypothesized that metformin and insulin alter myocardial substrate selection during cardiac surgery and may affect reperfusion cardiac function....
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.10.020
更新日期:2018-02-01 00:00:00
abstract::Seven surgically proven cases of a traumatic rupture of the right hemidiaphragm with a hepatic herniation were preoperatively diagnosed by radionuclide liver-spleen imagings, and they were retrospectively analyzed. All injuries resulted from blunt traumatic injury including automobile accidents, and there were associa...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract::A conical silicone rubber balloon was placed in the left hemithorax of fetal lambs and progressively inflated through an exteriorized catheter over the last trimester. Newborn lambs died of severe respiratory insufficiency, despite maximal resuscitation. The lungs were markedly hypoplastic with greatly reduced parench...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND:Less invasive operations such as laparoscopic surgery have been developed for treating gastrointestinal malignancies. However, the advantages of video-assisted thoracoscopic surgery for esophageal cancer (VATS-e) with regard to postoperative morbidity and mortality remains controversial. METHODS:We investig...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.12.006
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:A prior study revealed a paucity of surgical research in the 5 top-rated general surgery journals for 1998. The hypothesis of the current study was that a large amount of surgical research was published in other journals. METHODS:In all, 15 research journals and 9 surgery specialty journals were reviewed fo...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.07.005
更新日期:2010-01-01 00:00:00
abstract::The purpose of this project was to evaluate the acute and chronic effects of sclerotherapy on esophageal motility and function. We studied motility in eight patients before and after injection sclerotherapy of esophageal varices. We injected the varices with 5% sodium morrhuate twice during the first week and then at ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:We previously developed an intraoperative 10-point Surgical Apgar Score-based on blood loss, lowest heart rate, and lowest mean arterial pressure-to predict major complications after colorectal resection. However, because complications often arise after uncomplicated hospitalizations, we sought to evaluate w...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.01.015
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:A minimally invasive step-up approach to necrotizing biliary pancreatitis often requires multiple interventions, delaying cholecystectomy. The risk of gallstone-related complications during this time interval is unknown, as is the feasibility and safety of cholecystectomy after minimally invasive step-up tre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.11.002
更新日期:2020-12-12 00:00:00
abstract::A quantitative directional Doppler system was used to determine blood flow in 8 mm. aortoaortic Dacron grafts in dogs. The Doppler was calibrated with frequency standards and the output was integrated for one minute intervals. With the probe held at an angle of 60 degrees to the flow axis, the average frequency of the...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Parastomal hernia (PH) is a frequent complication of stoma formation, and recurrence after repair is common. A laparoscopic modified Sugarbaker technique (SB) may decrease the recurrence of PH compared with other methods. METHODS:A retrospective review, approved by the institutional review board, of patient...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.04.052
更新日期:2015-10-01 00:00:00
abstract::Cocaine abuse is now known to result in a wide variety of medical illnesses. We report our experience with one patient who had abdominal pain and was found to have near-total infarction of all abdominal viscera. The cause of this and other medical complications of cocaine abuse (i.e., extreme vasoconstriction) is disc...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Peptide receptor radionuclide therapy is a valid therapeutic option for pancreatic neuroendocrine neoplasms. The aim of this study was to describe an initial experience with the use of peptide receptor radionuclide therapy as a neoadjuvant agent for resectable or potentially resectable pancreatic neuroendocr...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.11.007
更新日期:2018-04-01 00:00:00
abstract::Fine-needle aspirations and cutting needle biopsies were performed on 415 patients with solitary thyroid nodules. All nodules were considered hypofunctioning by scintiscans. Specimens were adequate in 399 patients. Ten percent of these patients had thyroid cancers documented by thyroidectomies. Results from either or ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::Two granular cell tumors of the biliary tree are described, one in a 37-year-old black woman with obstructive jaundice and the other in a 26-year-old white woman with abdominal pain. These are rare soft tissue tumors that have an excellent prognosis when surgically excised. Almost all reported cases have been in young...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Sphingosine-1-phosphate, a pleiotropic bioactive lipid mediator, is an important player in cancer progression. Previous studies suggested that sphingosine-1-phosphate produced by sphingosine kinase 1, which is activated by phosphorylation, plays important roles in the progression of disease and metastasis. T...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.11.024
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Antigen injected subcutaneously (SQ) results in a strong systemic immune response, whereas antigen infused orally or by the portal vein tends to induce tolerance. Nontransgenic C57BL/6J (H-2(b)), or B6, mice and transgenic 2C mice (that express a cytotoxic T cell receptor against major histocompatibility com...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.05.010
更新日期:2005-08-01 00:00:00
abstract::An independent study program (ISP) was instituted in 1970 for a group of 32 preclerkship medical students picked randomly from a group of 64 volunteers. The academic achievements of these classes, as measured by mean National Board scores, is compared with their classmates in the lecture discussion (LD) program where ...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1977-06-01 00:00:00
abstract::During a 30-month period 73 patients underwent operation for choledocholithiasis. Thirty-three of these patients (45%) had cholangitis preoperatively. When compared to patients with common duct stones who had no preoperative cholangitis, patients with cholangitis were older (P less than 0.001), more likely to present ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Corticosteroid use continues to rise nationally. Studies have evaluated the impact of chronic steroid use on surgical outcomes in smaller populations. This study investigated the impact of chronic steroid use on perioperative surgical outcomes in a surgical cohort of more than 5 million surgical patients, us...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.12.016
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:A left hepatic graft in living donor liver transplantation (LDLT) often has 2 thin and short hepatic arterial stumps, which makes hepatic artery (HA) reconstructions much more difficult to perform. Consequently, some investigators regard using a left graft as a contraindication to LDLT, whereas others report...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.06.028
更新日期:2010-06-01 00:00:00
abstract::Segmental bilioenteric anastomosis procedures were performed on 22 patients with malignant hilar biliary obstructions. The majority of the bypasses were done to the segment 3 duct and a single anastomosis was performed in each patient. The operative mortality rate was 13.6% and morbidity, 27.3%. The biliary obstructio...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::The use of a modified bovine collagen graft as a low-pressure conduit was investigated by implantation into the iliocaval system of dogs. In the 210 day observation period, a patency rate of 87.5% was achieved. Nearly all graft failures occured within the first 14 days following implantation; failure after that time d...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:The importance of cigarette smoking in the etiology of peripheral arterial occlusive disease is well known, but there have been few studies that have quantified this relationship. METHODS:A case-control study design was used in which the case subjects were men with a history of claudication for at least 1 y...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Activated nuclear factor-kappaB (NF-kappaB) is associated reportedly with the pathogenesis of numerous malignancies. This study investigated whether a common insertion (ins)/deletion (del) polymorphism (-94 ins/del ATTG) in the NFKB1 promoter is associated with susceptibility to gastric cancer and its tumor ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.11.001
更新日期:2009-03-01 00:00:00
abstract::This retrospective study evaluated quantification of skin fluorescein delivery by fiberoptic fluorometry as a means of predicting the healing potential of an amputation site. Fluorometry uses a dual-channel fiberoptic light guide--one channel transmits blue light to excite the fluorescein in the skin under study, and ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00