Abstract：
BACKGROUND:Most ulcers occur with slough and need debridement treatment. Surgical treatment is usually performed but many patients need an additional chemical therapy to promote healing process. This type of wound bed preparation is slower than surgical one, but it is essential in those patients who are not eligible for surgery because of systemic diseases. A collagenase derived from the bacterium Clostridium hisolyticum is the most used. AIM:To evaluate the safety and the effectiveness of a new collagenase produced by Vibrio algynoliticum. MATERIALS AND METHODS:Forty patients were enrolled and daily treated for five weeks with Bionect Start® ointment. Parameters took into account were fibrin degradation and pain relief. The same team carried out treatment during the study period of five weeks. RESULTS:32 patients achieved a relevant reduction of the ulcer size, an improvement of the wound bed and a reduction of fibrin and exudates. Among of 32, 14 patients presented with a complete healing. Eight patients had mild or no improvements. The patients referred a remarkable pain reduction, 20 out of 40 patients reported a decrease in pain during treatment, 16 patients referred no pain at all and four patients had no significant changes. CONCLUSIONS:The application of this product on the lesions promotes vascularized granulation tissue and reduces formation of fibrin and exudate. Furthermore, a macroscopical margins proliferation is highlighted after a short time and an improvement of periwound skin is observed during the treatment period. Bionect Start® allowed easy removal of dressing, less pain for patient, reduction of dressing time.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Onesti MG,Fioramonti P,Carella S,Fino P,Sorvillo V,Scuderi Nsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
210-6issue
2eissn
1128-3602issn
2284-0729journal_volume
17pub_type
杂志文章abstract：OBJECTIVE:To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers. PATIENTS AND METHODS:The expression level of miR-551b was determined ...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201807_15496
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:The objective of this case report is to describe the management of anesthesia of a patient with an LVAD that underwent an emergency open appendectomy. Literature regarding emergency anesthesia management of such patients is still limited. A search in the PubMed engine with the keywords "LVAD appendectomy anes...
journal_title：European review for medical and pharmacological sciences
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更新日期：2016-08-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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