当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY期刊下所有文献 > Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.

Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.

Abstract：

:Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Mita Y,Noguchi-Yachide T,Ishikawa M,Hashimoto Y

doi

10.1016/j.bmc.2012.11.054

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

608-17

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(12)00949-2

journal_volume

21

pub_type

杂志文章

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