Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.

Abstract:

:A hydrolytically stable mimetic of the tumour antigen GM(3) lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination.

journal_name

Bioorg Med Chem

authors

Richichi B,Comito G,Cerofolini L,Gabrielli G,Marra A,Moni L,Pace A,Pasquato L,Chiarugi P,Dondoni A,Toma L,Nativi C

doi

10.1016/j.bmc.2013.03.021

subject

Has Abstract

pub_date

2013-05-15 00:00:00

pages

2756-63

issue

10

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(13)00234-4

journal_volume

21

pub_type

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