当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF STD & AIDS期刊下所有文献 > Discrepancies in diagnosis of incident HIV infection between antibody- and DNA-based tests in a phase III prevention trial in southern Africa.

Discrepancies in diagnosis of incident HIV infection between antibody- and DNA-based tests in a phase III prevention trial in southern Africa.

Abstract：

:Dried blood spots (DBS) are widely used to test for HIV in a variety of research and service delivery settings; however, uniform guidelines regarding collection, storage and DNA extraction processes have neither been developed nor evaluated. Previously published reports suggested DBS may be stored at room temperature for up to 60 days, and intensive stability tests have shown that DBS can withstand high temperatures, humidity and freeze-thawing. During the implementation of a large randomized controlled trial (RCT) in southern Africa, with HIV acquisition as the primary endpoint, we observed 65 instances when DBS samples collected from the same day as a positive HIV antibody test yielded negative DNA polymerase chain reaction (PCR) results. The source of this discrepancy may have been due to inadequate specimen volume, filter paper or DNA extraction procedures, but were most likely due to storage conditions that have been reported as acceptable in other settings.

journal_name

Int J STD AIDS

journal_title

International journal of STD & AIDS

authors

Montgomery ET,van der Pol B,van der Straten A,Ramjee G,de Bruyn G,Chipato T,Blanchard K,Padian NS,MIRA Team.

doi

10.1258/ijsa.2009.009124

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

649-52

issue

9

eissn

0956-4624

issn

1758-1052

pii

23/9/649

journal_volume

23

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

INTERNATIONAL JOURNAL OF STD & AIDS文献大全
  • Horizontally-acquired HIV infection in Kenyan and Swazi children.

    abstract：:Despite many reports of HIV-infected African children who have HIV-uninfected mothers, little is known about the extent and modes of horizontal HIV transmission in African children. We estimated the extent of horizontal HIV transmission in Swazi children by comparing child and mother HIV statuses in the 2006-2007 Swaz...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/ijsa.2009.009204

    authors： Okinyi M,Brewer DD,Potterat JJ

    更新日期：2009-12-01 00:00:00

  • Patient-led partner referral enhances sexually transmitted disease service delivery in two towns in the Central African Republic.

    abstract：:In Bambari and Bria, 2 towns in the Central African Republic (CAR), we analysed a patient-led partner referral programme within enhanced sexually transmitted disease (STD) services. New (index) patients received syndromic management, counselling about notifying and treating contacts, and vouchers for distribution. Fro...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：

    authors： Koumans EH,Barker K,Massanga M,Hawkins RV,Somse P,Parker KA,Moran J

    更新日期：1999-06-01 00:00:00

  • The limits of health-care seeking behaviour: how long will patients travel for STI care? Evidence from England's 'Patient Access and the Transmission of Sexually Transmitted Infections' ('PATSI') study.

    abstract：SUMMARY:The objective of this study was to identify factors associated with (i) longer patient travel time to genitourinary (GU) medicine clinics and (ii) not attending the nearest clinic. Questionnaires were completed by 4600 new attendees from seven sociodemographically and geographically different GU clinics across ...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/ijsa.2008.008205

    authors： Olonilua O,Ross JD,Mercer C,Keane F,Brook G,Cassell JA

    更新日期：2008-12-01 00:00:00

  • Evaluation of a pro-active strategy for managing tuberculosis-HIV co-infection in a UK tertiary care setting.

    abstract：:Management of tuberculosis (TB)-HIV co-infection is complicated by interactions between the diseases and their therapies. We developed and evaluated a strategy to (i) treat co-infected patients in a single co-infection clinic, (ii) maximize use of first-line drugs, (iii) delay antiretroviral therapy (ART) until two mo...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/0956462412472431

    authors： Wake RM,Poulikakos P,Groth J,Harrison TS,Macallan DC

    更新日期：2013-04-01 00:00:00

  • Differences in implementation of HIV/AIDS clinical research in developed versus developing world: an evidence-based review on protease inhibitor use among women and minorities.

    abstract：:The aim of this revision is to evaluate ethnicity and gender rate of enrolment in registrative clinical trials of the protease inhibitors (Pls) from 1996 to 2009. Company-sponsored, phase II or III registrative clinical trials of PIs were evaluated. Forty-nine clinical trials were included. Clinical trials were conduc...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章,评审

    doi：10.1258/ijsa.2012.012047

    authors： Seminari E,De Silvestri A,Scudeller L,Scotti V,Tinelli C

    更新日期：2012-12-01 00:00:00

  • Symptomatic HIV viraemia during a drug holiday: an argument against treatment interruption?

    abstract：:An HIV-positive African woman developed severe constitutional symptoms associated with rebound viraemia during a planned antiretroviral treatment interruption, requiring reinitiation of highly active antiretroviral therapy. ...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462041558131

    authors： Freedman E,Dhaliwal K,Estcourt C,Baily G

    更新日期：2004-08-01 00:00:00

  • Presentation of clinically suspected persistent chlamydial infection: a case series.

    abstract：:In vivo antimicrobial resistance has yet to be documented in Chlamydia trachomatis; however, there have been anecdotal reports of persistent infection. The purpose of this case series was to describe a group of patients who have persistent chlamydia infection despite adequate treatment and where re-infection was consi...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/0956462412472815

    authors： Pitt RA,Alexander S,Horner PJ,Ison CA

    更新日期：2013-06-01 00:00:00

  • HIV infection among patients with sexually transmitted diseases in rural South Africa.

    abstract：:A cross-sectional study of 360 patients presenting with sexually transmitted diseases (STDs) to a primary care clinic in KwaZulu/Natal, South Africa was done. Prevalence of HIV infection was 42.5%. HIV-infected patients were of similar age to uninfected patients (mean age 25.1 vs 26.1 years), but were less likely to b...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462981921486

    authors： Wilkinson D,Wilkinson N

    更新日期：1998-12-01 00:00:00

  • Prevalence of HIV and HIV-related diseases in the adult medical wards of a tertiary hospital in Durban, South Africa.

    abstract：:Our objective was to determine the prevalence of HIV and the distribution of HIV-related diseases among adult, medical inpatients. Consecutive admissions were recruited and a single ELISA assay was used to determine HIV infection. Demographic and clinical details were extracted from clinical records. Of 507 patients, ...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462011923336

    authors： Colvin M,Dawood S,Kleinschmidt I,Mullick S,Lallo U

    更新日期：2001-06-01 00:00:00

  • Psoriasis in HIV infection: an update.

    abstract：:Psoriasis is a prevalent systemic immune-mediated disease with cutaneous manifestations. In HIV-infected patients, psoriasis may have a higher incidence, present atypical and more exuberant clinical features, and is frequently recalcitrant to treatment. Despite this aggravated severity, treatment options for psoriasis...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章,评审

    doi：10.1177/0956462419827673

    authors： Alpalhão M,Borges-Costa J,Filipe P

    更新日期：2019-05-01 00:00:00

  • Racial and ethnic differences in knowledge and willingness to participate in HIV vaccine trials in an urban population in the Southeastern US.

    abstract：:Racial/ethnic minorities in the Southeastern USA are disproportionately affected by HIV, and would benefit from a preventive vaccine. We conducted a cross-sectional survey of 220 community college students in Atlanta to evaluate racial/ethnic differences in knowledge and willingness to participate in HIV vaccine trial...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/095646206775455667

    authors： Priddy FH,Cheng AC,Salazar LF,Frew PM

    更新日期：2006-02-01 00:00:00

  • A pilot study to investigate the treatment of anogenital warts with Topical Lithium Succinate cream (8% lithium succinate, 0.05% zinc sulphate).

    abstract：:The incidence of anogenital warts (condyloma acuminatum) is rapidly increasing while there is still no totally satisfactory treatment available. In light of the emphasis of experimental approaches toward the prevention of viral replication and evidence of the antiviral action of lithium salts it was proposed to invest...

    journal_title：International journal of STD & AIDS

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1258/0956462971920677

    authors： Ward KA,Armstrong KD,Maw RD,Winther MD,Gilburt SJ,Dinsmore WW

    更新日期：1997-08-01 00:00:00

  • Pediculosis pubis: presentation to ophthalmologist as pthriasis palpebrarum associated with corneal epithelial keratitis.

    abstract：:Pthiriasis palpebrarum caused by infestation with Pthirus pubis (crab louse) draws attention to pediculosis in the pubic and inguinal region. As pthiriasis is usually transmitted by sexual contact, many cases are likely to have other sexually transmitted diseases. A multidisciplinary approach is essential in the manag...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/095646206777323445

    authors： Manjunatha NP,Jayamanne GR,Desai SP,Moss TR,Lalik J,Woodland A

    更新日期：2006-06-01 00:00:00

  • Recommendations for the management of premature ejaculation: BASHH Special Interest Group for Sexual Dysfunction.

    abstract：:We present the British Association for Sexual Health and HIV (BASHH), Special Interest Group for Sexual Dysfunction updated recommendations for the management of premature ejaculation. The recommendations outline the physiology, prevalence, definitions, aetiological factors and patient assessment for this common sexua...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章,实务指引,评审

    doi：10.1258/095646206775220540

    authors： Richardson D,Goldmeier D,Green J,Lamba H,Harris JR,BASHH Special Interest Group for Sexual Dysfunction.

    更新日期：2006-01-01 00:00:00

  • Joint effects of alcohol and stimulant use disorders on self-reported sexually transmitted infections in a prospective study of Cambodian female entertainment and sex workers.

    abstract：:Female entertainment and sex workers (FESW) have high rates of alcohol and amphetamine-type stimulant (ATS) use, increasing risk for HIV/sexually transmitted infections (STI), and other negative outcomes. A prospective cohort of 1,198 FESW in a HIV/ATS use prevention intervention in Cambodia was assessed for alcohol a...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/0956462420964647

    authors： Evans JL,Couture MC,Carrico A,Stein ES,Muth S,Phou M,Aynar L,Song N,Chhit S,Neak Y,Maher L,Page K

    更新日期：2020-12-13 00:00:00

  • Retrospective review of clinical practice in chronic pelvic pain syndrome i.e. category III chronic prostatitis at two hospital sites over five years 2000-2005 (an audit).

    abstract：:All category III chronic prostatitis cases in two hospital sites were retrospectively reviewed from the year 2000 until 2005. The mean age of the patients was 38.7 years. Of these, 56.6% were St Bartholomew's Genitourinary Medicine Department patients and 43.5% were Southend Genitourinary Medicine Clinic patients. We ...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/095646207780658917

    authors： Evans DT,Jaleel H,Keefe A

    更新日期：2007-04-01 00:00:00

  • Emotional intimacy predicts condom use: findings in a group at high sexually transmitted disease risk.

    abstract：:Previous studies have reported an inverse relationship between condom use and emotional intimacy. The aim of this study was to determine the relationship between condom use and emotional intimacy. The study was a gonorrhoea case-comparison study with the samples being drawn from public health clinics (cases) and selec...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/ijsa.2009.009238

    authors： Damani R,Ross MW,Aral SO,Berman S,St Lawrence J,Williams ML

    更新日期：2009-11-01 00:00:00

  • HSV-2 antibodies in female sex workers in Vietnam.

    abstract：:Little information is available on the prevalence of herpes simplex type-2 (HSV-2) antibodies among groups at potential high risk of HIV in Asia. This study was carried out to determine the prevalence of HSV-2 antibodies and correlates of HSV-2 infection in female sex workers (FSWs) in border provinces of Vietnam. Nin...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/095646206778691176

    authors： O'Farrell N,Thuong NV,Nghia KV,Tram LT,Long NT

    更新日期：2006-11-01 00:00:00

  • Confirmatory serological testing of blood donors positive on TPHA screening in Singapore.

    abstract：:Seventy-two blood donors who were tested positive by the Singapore Blood Transfusion Service (SBTS) for Treponema pallidum haemagglutination (TPHA) test, were evaluated at the Department of Sexually Transmitted Diseases Clinic (DSC) between November 1994 to December 1996. All underwent syphilis serological testing, in...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462971919237

    authors： Wong SS,Teo DL,Chan RK

    更新日期：1997-12-01 00:00:00

  • Experience of HIV prevention interventions among female sex workers in Delhi, India.

    abstract：:This paper describes the effect of HIV prevention intervention among female sex workers in Delhi. Over a 2-year period we found a marked increase in condom use with little increase in HIV seroprevalence. The prevalence of HIV infection did not increase during the study period (1 positive among 701 in 1988 vs 1 positiv...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/095646249400500113

    authors： Singh YN,Malaviya AN

    更新日期：1994-01-01 00:00:00

  • Level 2 genitourinary medicine training and ongoing supervision -- how we can all benefit.

    abstract：:An innovative six-month, two sessions a week, funded clinical attachment programme was devised and introduced for practical training and experience to meet the demands and requirements of those wishing practical experience and training in genitourinary medicine. This has been generated by interest from previous theore...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462041211234

    authors： Pattman RS,Richards JE

    更新日期：2004-07-01 00:00:00

  • Ocular complications and loss of vision due to herpes zoster ophthalmicus in patients with HIV infection and a comparison with HIV-negative patients.

    abstract：:The aim of the work is to describe the occurrence of ocular complications and loss of vision due to herpes zoster ophthalmicus (HZO) in HIV-positive patients who received early antiviral therapy for HZO.This is a post hoc analysis of prospectively collected data.Twenty-four HIV-positive patients with HZO were included...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/0956462412472303

    authors： Nithyanandam S,Joseph M,Stephen J

    更新日期：2013-02-01 00:00:00

  • Seroprevalence of HSV-1 and HSV-2 antibodies in Canadian women screened for enrolment in a herpes simplex virus vaccine trial.

    abstract：:Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) infections continue to be among the most common and unrecognized sexually transmitted infections in the world. Although treatable, HSV-1 and HSV-2 infections remain incurable. Hence, there is interest in the development of a vaccine to prevent genital herpes. As part of a...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章,随机对照试验

    doi：10.1177/0956462412472822

    authors： Gorfinkel IS,Aoki F,McNeil S,Dionne M,Shafran SD,Zickler P,Halperin S,Langley J,Bellamy A,Schulte J,Heineman T,Belshe R

    更新日期：2013-05-01 00:00:00

  • The financial and service implications of splitting fixed-dose antiretroviral drugs - a case study.

    abstract：:In 2010/2011, regional commissioners withdrew payment for the fixed-dose combination Combivir, forcing a switch to component drugs. This was deemed clinically acceptable and annual savings of £44 k expected. We estimated the true costs of switching and examined patient outcomes. Information for 46 patients using Combi...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/0956462414530588

    authors： Taylor R,Carlin E,Sadique Z,Ahmed I,Adams EJ

    更新日期：2015-02-01 00:00:00

  • Health risk profile of prostitutes in Dublin.

    abstract：:This study examined the health risk profile of prostitutes in Dublin. Clinical records of all 150 new prostitutes who attended a drop-in clinic for prostitutes in Dublin city during the period 1991-1997 were reviewed. Variables examined included: age, use of injectable drugs, human immunodeficiency virus (HIV) status,...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462981922557

    authors： McDonnell RJ,McDonnell PM,O'Neill M,Mulcahy F

    更新日期：1998-08-01 00:00:00

  • Using a national guideline: an audit of the management of gonorrhoea in Newcastle upon Tyne.

    abstract：:The management of cases of gonorrhoea in the Genitourinary Medicine Department (GUM) of Newcastle upon Tyne in 1999 was audited. The sensitivity of microscopy in diagnosis was 90.4% for male urethral gonorrhoea and 26.6% for female genital gonorrhoea. The sensitivity of laboratory culture was 98.5%. Screening for Chla...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462001915057

    authors： Watson PG

    更新日期：2000-10-01 00:00:00

  • The management of Chlamydia trachomatis genital infection in genitourinary medicine clinics in the Wessex region.

    abstract：:The management of cases of Chlamydia trachomatis genital infection diagnosed in clinics in Wessex in the last quarter of 1996 was surveyed, and the results compared with those obtained in the national gonorrhoea audit. Treatment regimens were extremely varied both between and within clinics. Overall, 71% of patients s...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1258/0956462981921675

    authors： Priestley CJ

    更新日期：1998-02-01 00:00:00

  • Improving genitourinary medicine services in prison.

    abstract：:There are many challenges in providing genitourinary medicine services in prison. A review of current service arrangements is overdue. Developing a national standard for sexual health in prison must be a priority. Clinical governance arrangements underpinned by better health informatics and reliable measures of outcom...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章,评审

    doi：10.1258/ijsa.2008.008033

    authors： Lau R

    更新日期：2008-07-01 00:00:00

  • Sexually transmitted diseases in lesbians.

    abstract：:The limited published data support the assumption that lesbians are a low risk group for sexually transmitted diseases (STDs). However, there are virtually no contemporary data and the older papers do not take into account genital wart virus infection, now the third most prevalent STD in Britain. One of the dangers in...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/095646249000100304

    authors： Edwards A,Thin RN

    更新日期：1990-05-01 00:00:00

  • High prevalence of asymptomatic sexually transmitted infections in HIV-infected men who have sex with men: a stimulus to improve screening.

    abstract：:In Ireland the incidence of sexually transmitted infections (STIs) is steadily increasing while the number of new HIV-diagnoses in men who have sex with men has more than doubled in the past decade. This study investigated the prevalence of STIs in asymptomatic HIV-infected men who have sex with men (MSM) attending a ...

    journal_title：International journal of STD & AIDS

    pub_type： 杂志文章

    doi：10.1177/0956462414521165

    authors： Keaveney S,Sadlier C,O'Dea S,Delamere S,Bergin C

    更新日期：2014-09-01 00:00:00