Abstract:
:In vivo antimicrobial resistance has yet to be documented in Chlamydia trachomatis; however, there have been anecdotal reports of persistent infection. The purpose of this case series was to describe a group of patients who have persistent chlamydia infection despite adequate treatment and where re-infection was considered unlikely. Patients were selected using a clinical questionnaire. For inclusion patients had to have tested positive for C. trachomatis, at least twice, using a nucleic acid amplification test despite having been fully compliant with at least two rounds of recommended therapy and be deemed to be at low risk of re-infection. Patients were grouped into categories based on sexual behaviour. Twenty-eight patients are included in this case series; 46% declared no sexual contact since initial diagnosis (category 1), a further 36% declaring contact that was considered low risk of re-infection (categories 2-4); 61% showed signs and symptoms at initial presentation increasing to 75% at re-attendance. Thirty-nine percent of patients received azithromycin only while 48% received doxycycline also. This case series identifies patients with persistent chlamydia despite receiving treatment. There is a need for a case definition of clinical treatment failure, development of susceptibility testing methods and guidance on appropriate treatment for patients with persistent infection.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Pitt RA,Alexander S,Horner PJ,Ison CAdoi
10.1177/0956462412472815subject
Has Abstractpub_date
2013-06-01 00:00:00pages
469-75issue
6eissn
0956-4624issn
1758-1052pii
0956462412472815journal_volume
24pub_type
杂志文章abstract::Recognising the initial clinical presentation of acute HIV infection could enable earlier initiation of antiretroviral therapy and appropriate counselling to reduce the risk of transmission to others. Herein, we describe an unusual case of acute HIV infection presenting as limbic encephalitis and rhabdomyolysis. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414560777
更新日期:2015-10-01 00:00:00
abstract::The persistent sexual arousal syndrome (PSAS) is a newly described entity where women become involuntarily aroused genitally for extended periods in time in the absence of sexual desire. Genital vasoengorgement and oedema have been observed. These women are found to be usually very distressed. The cause of the syndrom...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/095646206776253480
更新日期:2006-04-01 00:00:00
abstract::Women attending a dedicated medical gynaecology and family planning referral clinic for women with HIV were surveyed using a standard questionnaire about their knowledge and attitudes to post-exposure prophylaxis after sexual exposure (PEPSE) and emergency hormonal contraception (EHC). Eighty percent of them had not h...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007159
更新日期:2008-01-01 00:00:00
abstract::Sweet's syndrome is a rare skin condition associated with both drug treatment and a number of different disease processes including haematological malignancies, inflammatory conditions and HIV infection. In this case report, we present a patient with HIV, haemophilia and hepatitis C who presented to our team with sign...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009314
更新日期:2012-06-01 00:00:00
abstract::Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16-22 years)...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462417740487
更新日期:2018-05-01 00:00:00
abstract::This paper describes the effect of HIV prevention intervention among female sex workers in Delhi. Over a 2-year period we found a marked increase in condom use with little increase in HIV seroprevalence. The prevalence of HIV infection did not increase during the study period (1 positive among 701 in 1988 vs 1 positiv...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249400500113
更新日期:1994-01-01 00:00:00
abstract::We aim to assess the usefulness of the cytomegalovirus (CMV) pp65 antigenaemia test, also called the CMV direct antigen test (DAT), in the management of patients with advanced human immunodeficiency virus (HIV) infection; we studied all patients who had pp65 assays between 8 September 1995 and 30 August 1996. Twenty-t...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
doi:10.1258/0956462981922809
更新日期:1998-09-01 00:00:00
abstract::Peripheral neuropathy is one of the most common neurological complications of HIV infection with a 30-60% lifetime prevalence. Newer HIV drugs cause less peripheral neuropathy, but patients are now living long enough to develop concomitant diabetes-related, vascular-related, and chemotherapy-related neuropathy so it c...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416656688
更新日期:2017-02-01 00:00:00
abstract::HIV testing and counselling is crucial in identifying new HIV cases and linking them to treatment. Provider-initiated testing and counselling can help to increase uptake of HIV testing and counselling and HIV case detection. We implemented provider-initiated testing and counselling in 32 health facilities in Ebonyi St...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418783533
更新日期:2018-12-01 00:00:00
abstract::For people immunosuppressed by human immunodeficiency virus (HIV), we expect an increase in cancer incidence similar to that documented in transplant patients. We examined the cancer spectrum in an HIV-infected cohort, specifically malignancies not currently associated with acquired immunodeficiency syndrome (AIDS), i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913574
更新日期:1999-12-01 00:00:00
abstract::Female entertainment and sex workers (FESW) have high rates of alcohol and amphetamine-type stimulant (ATS) use, increasing risk for HIV/sexually transmitted infections (STI), and other negative outcomes. A prospective cohort of 1,198 FESW in a HIV/ATS use prevention intervention in Cambodia was assessed for alcohol a...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420964647
更新日期:2020-12-13 00:00:00
abstract::We describe a case of cryptococcal meningitis in a patient known to have HIV who presented initially with ocular cryptococcosis. This case highlights to clinicians the need to be aware of this association and to carry out relevant investigations so as to treat these patients appropriately. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009132
更新日期:2012-05-01 00:00:00
abstract::In a retrospective database study at two HIV treatment centres, medical records were accessed to evaluate long-term efficacy and safety parameters in all HIV-infected adults who had achieved HIV-1 RNA <50 copies/mL following the initiation of fosamprenavir (FPV)/ritonavir (RTV) 1400 mg/100 mg once-daily (QD)-containin...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009161
更新日期:2012-03-01 00:00:00
abstract::Two cases are described of treatment-resistant vulvodynia that responded well to gabapentin. Gabapentin, an anti-epileptic drug, has been used in the treatment of neuropathic pain such as diabetic neuropathy and post-herpetic neuralgia. However, there has been little experience of its use in the relief of symptoms in ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462021924802
更新日期:2002-03-01 00:00:00
abstract::A combination of in-depth interviews (n = 38) and surveys (n = 203) were used to (1) identify strategies to recruit persons at high risk for HIV infection; (2) determine whether one strategy was more successful than others; and (3) describe motivators and barriers to participation in HIV-prevention studies. From in-de...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011173
更新日期:2012-03-01 00:00:00
abstract::We determined the retention rate of patients infected with HIV who resumed care after being tracked at the Infectious Diseases Clinic (IDC) in Kampala, Uganda. Between April 2011 and September 2013, patients who missed their clinic appointment for 8-90 days were tracked, and those who returned to the clinic within 120...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414529098
更新日期:2015-01-01 00:00:00
abstract::To follow the progression of HIV seropositivity among heterosexual adults at risk for HIV infection in the country of Rwanda prospectively, up to 100 patients with sexually transmitted diseases (STD) were tested each month from 1988 to 1991 at the health centre of Biryogo, which is located in a very crowded sector of ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249300400406
更新日期:1993-07-01 00:00:00
abstract::Limited data exist on hepatitis B revaccination strategies for HIV-infected individuals who do not develop immunity after the first vaccination series. A retrospective cohort study was conducted to assess the immunogenicity of the second series of hepatitis B vaccine given in standard dosing (SD) and double dosing (DD...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415596498
更新日期:2016-09-01 00:00:00
abstract::High annual figures of sexually transmitted infections (STIs) are diagnosed in the Netherlands despite significant efforts to control them. Herein, we analyse trends and determinants of STI diagnoses, co-infections, and sexual risks among visitors of 26 STI clinics between 2007 and 2011. We recorded increased positivi...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413491736
更新日期:2014-01-01 00:00:00
abstract::HIV status awareness is key to prevention, linkage-to-care and treatment. Our study evaluated the accessibility and potential willingness of HIV self-testing among men who have sex with men (MSM) and transgender women in Peru. We surveyed four pharmacy chains in Peru to ascertain the commercial availability of the ora...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416630674
更新日期:2017-02-01 00:00:00
abstract::Background In Kenya, HIV incidence and prevalence have declined. HIV rates are lower in rural areas than in urban areas. However, HIV infection is reported higher in men in rural areas (4.5%) compared to those in urban areas (3.7%). Objectives This study examined HIV knowledge, feelings, and interactions towards HIV-i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416680764
更新日期:2017-08-01 00:00:00
abstract::Stavudine is a potent nucleoside analogue and a well-recognized component of highly active antiretroviral therapy. Clinical trials have shown stavudine to have a superior or at least comparable virological efficacy and immune reconstitution when compared with other nucleoside analogues. Studies have shown that the pre...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/095646203322491842
更新日期:2003-10-01 00:00:00
abstract::Perceived health-related quality of life (QOL) of 113 adult people living with HIV/AIDS (PHA) attending an outpatient hospital clinic was assessed upon initial registration using the Medical Outcomes Study SF-36. QOL ratings on both physical functioning and psychological well-being aspects of the SF-36 were lower than...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011923598
更新日期:2001-08-01 00:00:00
abstract::Lactobacillus sp. are commensal organisms that are increasingly reported to cause invasive infections among immunosuppressed persons. However, few data exist regarding the occurrence and risk factors of these infections among HIV-infected persons. Further, the safety of products that contain lactobacilli (e.g. probiot...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1177/0956462415590725
更新日期:2016-11-01 00:00:00
abstract::Sexual functioning is often neglected in the care of HIV-infected patients. Little information exists about the relationship between hormonal factors, psychological factors, medication, HIV disease stage and sexual functioning among persons with HIV disease. In this study, 50 HIV+ men completed the Derogatis Sexual Fu...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921332
更新日期:1998-11-01 00:00:00
abstract::Self-inserted vaginal tampons for the molecular diagnosis of non-ulcerative STIs were evaluated. Cervical and vaginal swabs, tampons and urines were collected from 185 first-time antenatal clinic attendees. Cultures and nucleic acid amplification assays (NAA) were performed. The sensitivity of PCR on tampons for Trich...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646204322764271
更新日期:2004-02-01 00:00:00
abstract::Pneumocystis jirovecii pneumonia (PCP) prophylaxis may be discontinued when CD4 is > or =200 cells/mm(3) for three months in response to highly active antiretroviral therapy (HAART). Unlike CD4, the total lymphocyte count (TLC) is inexpensive and widely available in resource-constrained countries. Paired TLC and CD4 v...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009090
更新日期:2010-06-01 00:00:00
abstract::Women who have a prevention mindset may opt for concurrent use of oral pre-exposure prophylaxis (PrEP) and all forms of contraception; we therefore assessed how contraception may influence PrEP use or vice versa. We analyzed data from Kenyan and Ugandan HIV-uninfected non-pregnant women in sero-discordant partnerships...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420951501
更新日期:2020-11-01 00:00:00
abstract::The blood-taking practices and prevalence of needle-stick injuries were recorded for 46 house officers working at the two largest teaching hospitals in Sheffield and 38 house officers working at three hospitals in London. Wearing gloves when performing venesection or inserting an intravenous cannula was generally perc...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200109
更新日期:1991-01-01 00:00:00
abstract::Although important, the foreskin is not absolutely essential to penile function. Dysfunction is common and a cause of considerable morbidity, and is sometimes associated with mortality from squamous cell carcinoma (SCC). Penile dermatoses herald, complicate or cause preputial dysfunction. Their effective diagnosis and...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/0956462011922922
更新日期:2001-04-01 00:00:00