Precision medicine for lung cancer: role of the surgical pathologist.

abstract：:The sophomore pathology course at the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, was substantially modified with the intention of promoting guided, independent learning. The emphasis has been shifted from lectures to other modalities of instruction. This article...

journal_title：Archives of pathology & laboratory medicine

authors： Raskova J,Martin EG,Trelstad RL,Shea SM

更新日期：1989-02-01 00:00:00

abstract：CONTEXT:The unprecedented advances in cancer genetics and genomics are rapidly affecting clinical management and diagnostics in solid tumor oncology. Molecular diagnostics is now an integral part of routine clinical management in patients with lung, colon, and breast cancer. In sharp contrast, molecular biomarkers have...

journal_title：Archives of pathology & laboratory medicine

authors： Netto GJ,Cheng L

更新日期：2012-04-01 00:00:00

abstract：CONTEXT:'Atypical' has served as a descriptive term in cytology since the birth of the specialty by Dr Papanicolaou. This indeterminate diagnosis often results in repeat biopsies or additional tissue sampling and a needless delay in patient care if used inappropriately. Because of the definitional ambiguity of this ter...

journal_title：Archives of pathology & laboratory medicine

authors： Koen TM,Mody DR,Scheiber-Pacht M,Fairley T,Thrall MJ

更新日期：2010-07-01 00:00:00

abstract：CONTEXT:The immunophenotypic profile of basophils is not yet fully established, and the immunophenotypic changes in chronic myelogenous leukemia are not fully characterized. OBJECTIVE:To establish a comprehensive immunophenotypic spectrum of normal basophils and to assess the range of immunophenotypic aberrations of b...

journal_title：Archives of pathology & laboratory medicine

authors： Han X,Jorgensen JL,Brahmandam A,Schlette E,Huh YO,Shi Y,Awagu S,Chen W

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Pseudosarcomatous myofibroblastic tumors (PMTs) of the urogenital tract are rare but distinctive lesions. Despite their benign behavior, they are frequently misinterpreted as leiomyosarcomas and rhabdomyosarcomas in preoperative biopsies and even in resected specimens because of their atypical spindle-cell fe...

journal_title：Archives of pathology & laboratory medicine

authors： Watanabe K,Baba K,Saito A,Hoshi N,Suzuki T

更新日期：2001-08-01 00:00:00

abstract：CONTEXT:- Different types of mature B-cell lymphomas, including plasma cell neoplasms, exhibit distinct immunohistochemical profiles, which enable them to be correctly diagnosed. However, except for rare examples of lymphoma-specific immunohistochemistry, such as cyclin D1 in mantle cell lymphoma and annexin A1 in hair...

journal_title：Archives of pathology & laboratory medicine

authors： Wang HY,Zu Y

更新日期：2017-09-01 00:00:00

abstract：:In this time of significant change in pathology and medicine, pathology's future is uncertain. Many issues, including the emergence of molecular medicine, the demand for personalized medicine, confusing payment schemes, increasing governmental regulation, medical education challenges, administrative relationships, and...

journal_title：Archives of pathology & laboratory medicine

authors： Allen TC

更新日期：2012-02-01 00:00:00

abstract：:Rectal carcinoma is uncommonly associated with systemic metastases in the absence of liver metastases, reflecting the predilection for spread via the portal system. Occasionally, isolated lung metastases are seen, which are usually attributed to spread via the portosystemic anastomoses in the distal rectum. However, m...

journal_title：Archives of pathology & laboratory medicine

authors： Mathew P,Fleming D,Adegboyega PA

更新日期：2000-08-01 00:00:00

abstract：CONTEXT:- Urinary tract infections are characterized by the presence of microbial pathogens within the urinary tract. They represent one of the most common infections in hospitalized and clinic patients. OBJECTIVES:- To model the parameters of the Sysmex UF-1000i to the gold standard, urine culture, and to compare the...

journal_title：Archives of pathology & laboratory medicine

authors： Erdman P,Anderson B,Zacko JC,Taylor K,Donaldson K

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Our understanding of molecular events in the pathogenesis of hematologic malignancies has evolved substantially. The research data gathered in the past 3 decades have led to the definition of neoplastic disorders based on specific genetic and molecular alterations, which is reflected in the current World Health...

journal_title：Archives of pathology & laboratory medicine

authors： Pozdnyakova O,Kutok JL,Rodig SJ

更新日期：2012-05-01 00:00:00

abstract：:We report a case of sialadenoma papilliferum arising in the adenoids in a 2-year-old child. The tumor demonstrated papillary and adenomatous proliferations, suggestive of minor salivary gland origin. A review of the literature indicated no reported cases of this neoplasm arising in individuals this young. The location...

journal_title：Archives of pathology & laboratory medicine

authors： Masi JD,Hoang KG,Sawyer R

更新日期：1986-06-01 00:00:00

abstract：:A 47-year-old man presented to the otolaryngologist with a 7-year history of a mass of the cheek. Fine-needle aspiration revealed foci of spindled cells admixed with abundant fat and myxoid material. A diagnosis of spindle cell lipoma was rendered on the resected specimen. The cytologic findings of spindle cell lipoma...

journal_title：Archives of pathology & laboratory medicine

authors： Fasig JH,Robinson RA,McCulloch TM,Fletcher MS,Miller CK

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:This report describes a new and improved "quick-hot Gram-chromotrope" staining technique that detects microsporidian spores in clinical specimens, such as stool, urine, saliva, nasopharyngeal fluid, and bronchoalveolar lavage samples, as well as in formalin-fixed and paraffin-embedded tissue sections. DESIGN...

journal_title：Archives of pathology & laboratory medicine

authors： Moura H,Schwartz DA,Bornay-Llinares F,Sodré FC,Wallace S,Visvesvara GS

更新日期：1997-08-01 00:00:00

abstract：:The frequency of light chain deposition nephropathy relative to renal amyloidosis and Bence Jones cast nephropathy was determined in a necropsy study of 57 patients with myeloma. The diagnosis of light chain deposition nephropathy was established by immunofluorescence microscopic examination of kidney tissue demonstra...

journal_title：Archives of pathology & laboratory medicine

authors： Iványi B

更新日期：1990-09-01 00:00:00

abstract：:A 52-year-old man, suffering for years from malabsorption due to endemic sprue, developed progressive bowel dysfunction, ie, recurrent ileus and intestinal pseudo-obstruction. Because of partial volvulus formation, ileocecal resection was performed. Histopathologic examination of the resected specimen revealed signs o...

journal_title：Archives of pathology & laboratory medicine

authors： Ruchti C,Eisele S,Kaufmann M

更新日期：1990-01-01 00:00:00

abstract：CONTEXT:- Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis. Several studies have analyzed potential prognostic markers, but histologic type remains the single most important prognostic factor. Histologic subtypes of epithelioid MPM seem to have prognostic and therapeutic implications. Interobser...

journal_title：Archives of pathology & laboratory medicine

authors： Brcic L,Vlacic G,Quehenberger F,Kern I

更新日期：2018-06-01 00:00:00

abstract：:Physician shortages are acute in developing countries, where disease burden is the greatest and resources for health care are very limited. A lack of pathologists in these countries has lead to delays in diagnosis and misdiagnoses that adversely affect patient care and survival. The introduction of telepathology into ...

journal_title：Archives of pathology & laboratory medicine

authors： Hitchcock CL

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Most gastric gastrointestinal stromal tumors (GISTs) express CD117/c-kit, as do a subset of metastatic melanomas, leading to a diagnostic dilemma in some cases. OBJECTIVE:To further differentiate GISTs from melanoma, we investigated expression of melanoma markers in GISTs using a well-characterized set of gast...

journal_title：Archives of pathology & laboratory medicine

authors： Guler ML,Daniels JA,Abraham SC,Montgomery EA

更新日期：2008-08-01 00:00:00

abstract：:A rare angiomyxoma of umbilica cord occurred in a male infant. The presence of such a tumor with its vascular component arising from a hypoplastic umbilical artery supports the hypothesis that the lesions arose through improper placental vascularization. ...

journal_title：Archives of pathology & laboratory medicine

authors： Carvounis EE,Dimmick JE,Wright VJ

更新日期：1978-04-01 00:00:00

abstract：:We describe a case of ovarian adenoid cystic carcinoma (ACC) of the left ovary in a 23-year-old woman. The tumor had the typical cribriform pattern of ACC, lacked any component of surface epithelial carcinoma, and showed myoepithelial differentiation. The features of salivary gland-type tumor seen in this case are unu...

journal_title：Archives of pathology & laboratory medicine

authors： Zámecník M,Michal M,Curík R

更新日期：2000-10-01 00:00:00

abstract：:We studied a case of Sturge-Weber syndrome in a 66-year-old woman, who displayed associated angiomas of the thyroid gland and choroid plexi and leptomeningeal melanosis. These findings are discussed in light of the proposed pathogenesis of the syndrome and its relationship to the other neuroectodermal dysplasias. ...

journal_title：Archives of pathology & laboratory medicine

authors： Bentz MS,Towfighi J,Greenwood S,Zaino R

更新日期：1982-02-01 00:00:00

abstract：:Rapid tissue diagnosis during acute events associated with renal transplantation is often necessary to permit immediate decisions regarding initiation or modification of therapy. To achieve this, we performed frozen section analyses with cryoprotected alcoholic Bouin's-fixed tissue, which permits evaluation within 2.5...

journal_title：Archives of pathology & laboratory medicine

authors： Cohen AH,Gonzalez S,Nast CC,Wilkinson A,Danovitch GM

更新日期：1991-04-01 00:00:00

abstract：CONTEXT:The College of American Pathologists Cancer Case Summaries templates provide a method for including all necessary pathology information in surgical pathology reports with cancer. How effective these templates are at ensuring a complete report, as measured by a separate outside tumor registry, is not known. OBJ...

journal_title：Archives of pathology & laboratory medicine

authors： Renshaw SA,Mena-Allauca M,Touriz M,Renshaw A,Gould EW

更新日期：2014-01-01 00:00:00

abstract：:Intracellular inclusions in lymphoproliferative disorders are not common. Multiple different types of inclusions have been reported in chronic lymphocytic leukemia (CLL), including vacuoles, crystals, and pseudocrystals. Most of the reported cases were seen in the bone marrow lymphocytes, and the majority of these on ...

journal_title：Archives of pathology & laboratory medicine

authors： Dorion RP,Shaw JH

更新日期：2003-05-01 00:00:00

abstract：:Coronary ostial stenosis is a cause of angina pectoris and sudden death. It is due mainly to atherosclerosis, syphilis, and iatrogenic disease. The last is of growing importance because of the frequency of coronary arteriography and surgical procedures on the aortic valve. Since both may cause stenosis of the coronary...

journal_title：Archives of pathology & laboratory medicine

authors： Knutson EL,Smith JC

更新日期：1976-03-01 00:00:00

abstract：:Stomachs of 22 rats treated with aspirin for six months were examined histologically at times ranging from 6 to 18 months after completion of treatment. Healed chronic gastric ulcers were found in 20 rats. Glandular dysplasia was present at the sites of healed ulcers in 12 rats, the glands extending into the submucosa...

journal_title：Archives of pathology & laboratory medicine

authors： St John DJ,Yeomans ND,Bourne CA,de Boer WG

更新日期：1977-01-01 00:00:00

abstract：:Silicone, commonly used in cosmetic procedures owing to its presumed inertness, can yield serious sequelae including acute embolization and pneumonitis. Chronic pulmonary sequelae in response to silicone injection have not been previously described. We report a case of chronic progressive granulomatous pneumonitis in ...

journal_title：Archives of pathology & laboratory medicine

authors： Hariri LP,Gaissert HA,Brown R,Ciaranello A,Greene RE,Selig MK,Kradin RL

更新日期：2012-02-01 00:00:00

abstract：:Ten cases of gynecomastia were studied by electron microscopy. The ducts showed proliferation of both epithelial and myoepithelial cells. Intracytoplasmic lumina, previously thought to be a feature of malignant breast lesions, were seen. Squamous metaplasia was observed in some cases. The stroma showed fibroblasts, my...

journal_title：Archives of pathology & laboratory medicine

authors： Hassan MO,Olaizola MY

更新日期：1979-11-01 00:00:00

abstract：CONTEXT:All Food and Drug Administration-approved methods in the United States for human papillomavirus testing including the Hybrid Capture 2 human papillomavirus assay and the Roche cobas human papillomavirus test are approved for cytology specimens collected into ThinPrep media but not for specimens collected into S...

journal_title：Archives of pathology & laboratory medicine

authors： Levi AW,Bernstein JI,Hui P,Duch K,Schofield K,Chhieng DC

更新日期：2016-02-01 00:00:00

abstract：:Assays for Chlamydia trachomatis antigen are being increasingly used in lieu of traditional cell culture methods for detection of the organism in patient specimens. While results from these assays are available considerably earlier than are those from culture, the assays have been less sensitive and specific than cult...

journal_title：Archives of pathology & laboratory medicine

authors： Kellogg JA

更新日期：1989-05-01 00:00:00