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Breast feeding and the risk of severe cholera in rural Bangladeshi children.

Abstract：

:The association between breast feeding and the risk of severe cholera was examined in a case-control study of rural Bangladeshi children under 36 months of age who were studied in 1985-1986 during a field trial of killed oral cholera vaccines. A total of 116 cases who were treated for severe cholera were compared with 464 age-matched community controls without severe cholera. Overall, the odds ratio relating breast feeding to severe cholera (0.30, p less than 0.0001) reflected a 70% reduction in the risk of severe cholera among breast-fed children. The estimated reduction of risk declined with age, but was clearly evident in children up to 30 months of age. Although the association between breast feeding and a reduced risk of severe cholera was not significantly greater in children of mothers who had received cholera vaccine than in children whose mothers had received placebo during the trial, maternal vaccination per se was suggestively associated with a reduced risk of severe cholera in their nonvaccinated children (odds ratio = 0.53, p = 0.05). These results indicate that breast feeding was associated with a substantial reduction of the risk of severe cholera and raise the possibility that vaccination of mothers may provide protection to their young children in endemic settings.

journal_name

Am J Epidemiol

journal_title

American journal of epidemiology

authors

Clemens JD,Sack DA,Harris JR,Khan MR,Chakraborty J,Chowdhury S,Rao MR,van Loon FP,Stanton BF,Yunus M

doi

10.1093/oxfordjournals.aje.a115515

keywords:

["Age Distribution","Age Factors","Asia","Bangladesh","Biology","Breast Feeding","Child","Data Analysis","Delivery Of Health Care","Demographic Factors","Developing Countries","Diarrhea","Diarrhea, Infantile","Diseases--prevention and control","Evaluation","Health","Health Services","Immunization","Incidence","Infant Nutrition","Measurement","Nutrition","Population","Population Characteristics","Primary Health Care","Research Methodology","Risk Factors","Rural Population","Southern Asia","Statistical Regression","Vaccination--women","Youth"]

subject

Has Abstract,Author List Incomplete

pub_date

1990-03-01 00:00:00

pages

400-11

issue

eissn

0002-9262

issn

1476-6256

journal_volume

131

pub_type

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Breast feeding and the risk of severe cholera in rural Bangladeshi children.