Abstract：
:Outbreaks of respiratory tract illnesses (RTI) in adult humans during October and November 1975 at McMurdo Station, Antarctica, were investigated by viral isolation and serologic procedures. The recovery of viral agents was enhanced by use of cell cultures in the field. Recoveries of parainfluenzaviruses types 1 and 3 and rhinoviruses were made from 10 of 39 nasal washings. Parainfluenzaviruses types 1 and 3 accounted for 50 and 30 per cent, respectively, of the total viruses recovered during October and November 1975. Acute and convalescent sera collected from 32 adult humans were examined for antiviral antibody by hemagglutination inhibition (HI) and radioimmunoassay (RIA) techniques. Serologic responses (HI and RIA) confirmed that parainfluenzaviruses were the predominent cause of RTI at McMurdo Station during that time. The temporal relationship between parainfluenzaviral diseases occurring in US communities and at McMurdo suggests that these viruses are transported to the Antarctic by personnel originating within the US. Standardization of the RIA allowed sequential assay of large numbers of sera using multiple preparations of radiolabeled indicator antibody, while ensuring the reproducibility of antiviral antibody titers to within one twofold dilution between subsequent labeled antibody preparations. The RIA detected both lower levels of virus specific antibody and more serologic responses than could be detected by HI.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Parkinson AJ,Muchmore HG,Scott LV,Kalmakoff J,Miles JAdoi
10.1093/oxfordjournals.aje.a112857subject
Has Abstractpub_date
1979-12-01 00:00:00pages
753-63issue
6eissn
0002-9262issn
1476-6256journal_volume
110pub_type
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112529
更新日期：1978-03-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2004-03-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2007-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114187
更新日期：1985-12-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112098
更新日期：1975-04-01 00:00:00
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更新日期：2013-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112498
更新日期：1977-12-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2015-02-15 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114220
更新日期：1986-01-01 00:00:00
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更新日期：2008-05-15 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114487
更新日期：1986-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008859
更新日期：1996-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115600
更新日期：1990-06-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2001-02-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/aje/kwj127
更新日期：2006-06-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115246
更新日期：1989-06-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116160
更新日期：1991-10-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116834
更新日期：1993-07-15 00:00:00
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journal_title：American journal of epidemiology
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doi：10.1093/aje/kwr035
更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：American journal of epidemiology
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更新日期：2009-12-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2020-05-05 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
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更新日期：2018-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1997-05-15 00:00:00
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更新日期：2002-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/aje/kwi081
更新日期：2005-03-15 00:00:00
