Abstract：
:The advances in science have resulted in the emergence of nanotechnology, which deals with the design and use of tools and devices of size 1-100 nm. The application of nanotechnologies to medicine is thus termed nanomedicine. Significant research has been focused on this new and exciting field and this review article will describe the basics of nanomedicine. This is followed by its experimental and clinical applications in diagnostics, drug therapy and regenerative medicine. Safety issues of in vivo use of nanomaterials are also discussed. In the future, it is foreseen that nanomedicine will facilitate the development of personalized medicine and will have a major impact on the delivery of better healthcare.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Wong KK,Liu XLdoi
10.1007/s00383-012-3162-ysubject
Has Abstractpub_date
2012-10-01 00:00:00pages
943-51issue
10eissn
0179-0358issn
1437-9813journal_volume
28pub_type
杂志文章,评审abstract：:We present the results of a 6-year review of appendicitis. In the event of diagnostic doubt, a policy of active observation was instituted. This review endorses the validity of such a policy, indicating that it does not expose patients to increased morbidity. Data were collected prospectively over a 6-year period on 1...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000483
更新日期：2001-03-01 00:00:00
abstract：:Inflammatory pseudotumors (IPT) are uncommon mass lesions arising most typically in the lungs of young adults. These tumors are so named because of the difficulty in distinguishing them preoperatively from malignant lesions. IPT are characterized histologically by localized fibrous proliferations with infiltration by ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830000518
更新日期：2001-09-01 00:00:00
abstract：:The use of ureteric stents in reimplantation surgery is important. The younger the patient, the more important the stenting of ureters post reimplantation becomes, because even minimal oedema following surgery will produce ureteric obstruction unless stents are in place. JJ stents are now the preferred method of choic...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1205-8
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:For esophagus tissue engineering, isolation and proliferation of esophageal epithelial cells (EEC) is a pre-requisite for scaffold seeding to create constructs. The aim of this study was to sort EEC expressing cytokeratin markers and their proliferative subpopulations; also, to investigate the viability of di...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2512-x
更新日期：2010-01-01 00:00:00
abstract：:Gastroesophageal reflux (GER) is common after repair of esophageal atresia with a distal tracheoesophageal fistula (EATOF). In a retrospective study we assessed whether early 18-h pH monitoring can predict the development of EATOF-associated gastroesophageal reflux. During 1980-1997, 90 consecutive patients had primar...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1270-z
更新日期：2004-09-01 00:00:00
abstract：:Nitrofen induces in rats diaphragmatic hernia (CDH) with heart and lung hypoplasia by a mechanism involving oxidation. The aim of this study was to examine if prenatal administration of the anti-oxidant agent vitamin E (VitE) prevents to some extent heart and lung hypoplasia. Pregnant rats received on E9.5 either 100 ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1005-6
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Intestinal failure-associated liver disease (IFALD) remains a serious problem in the treatment of infants with nutritional problems and short bowel syndrome. METHODS:A review of the recent literature from 2010 to 2016, concentrating on articles related to the pathophysiology of IFALD and to outcomes of nove...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-4042-7
更新日期：2017-04-01 00:00:00
abstract：:Interstitial cells of Cajal (ICCs) have been reported to play the role of a pacemaker in regulating bowel motility. The relationship between neurons and ICCs, however, remains unclear. Hirschsprung's disease (HD) is an ideal model for investigating this relationship. The operated specimens obtained from 6 short and 3 ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0931-z
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Subclinical varicocele is a relative rare condition. The aim of this study is to identify the role of bioflavonoids in the management of subclinical varicocele. MATERIALS AND METHODS:We analyzed the medical charts of patients treated for subclinical varicocele with bioflavonoids between 1999 and 2004; inclu...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2574-9
更新日期：2010-05-01 00:00:00
abstract：:The case of a 9-year-old girl with a Mycobacterium tuberculosis inflammatory myofibroblastic tumor (IMT) of the left lobe of the liver is reported. The tumor was surgically excised and had histological features diagnostic of IMT, a positive Ziehl-Nielsen staining for acid-fast bacilli and a positive polymerase chain r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2361-7
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:Recognition of physical child abuse is imperative for ensuring children's safety. Screening tools (ST) may increase identification of physical abuse; however, the extent of their use is unknown. This study assessed use of STs for physical abuse in children's hospitals and determined attitudes regarding STs. ME...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3916-z
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Inguinal hernia repair is the most frequently performed surgical procedure in infants and children. Especially in premature infants, prevalence reaches up to 30% in coincidence with high rates of incarceration during the first year of life. These infants carry an increased risk of complications due to genera...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3590-y
更新日期：2014-10-01 00:00:00
abstract：:The presacral cystic teratoma in an infant is reported. The cyst consisted solely of central nervous system tissue. This pathologic finding is extremely rare. A review of the literature reveals no previous report of a teratoma arising in this manner. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0831-2
更新日期：2002-12-01 00:00:00
abstract：:A modified technique of laparoscopic pyloromyotomy was used to treat infantile hypertrophic pyloric stenosis. Introducing a 5-mm periumbilical port for visualization, two stab wounds are made on either side laterally to directly insert 2.7-mm instruments for manipulation. From the left, the stomach is grasped - not th...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050307
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Pediatric burn injuries are one of the leading causes of preventable morbidity and mortality in Sub-Saharan Africa. Research on the complex system of social, economic and cultural factors contributing to burn injuries in this setting is much needed. METHODS:We conducted a prospective questionnaire-based ana...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3761-5
更新日期：2015-11-01 00:00:00
abstract：:In many very-low-birth-weight (VLBW) infants the ductus arteriosus fails to close spontaneously, and they subsequently develop signs and symptoms of poor tissue perfusion and heart failure. This study evalutes the results of early surgical closure of patent ductus arteriosus (PDA). We retrospectively reviewed the reco...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000515
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:Primary spontaneous pneumothorax (PSP) is managed in accordance with the adult British Thoracic Society (BTS) guidelines due to lack of paediatric evidence and consensus. We aim to highlight the differences and provide a best practice surgical management strategy for PSP based on experience of two major paediat...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3787-8
更新日期：2015-12-01 00:00:00
abstract：:The interstitial cells of Cajal (ICC) play an important role in the control of gut motility. The recognition that the ICC cell membrane harbors the c-kit receptor (CD117) sparked rapid advancement in ICC research on the gut and certain pathologies using immunochemical and molecular methods. The question arises whether...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1314-4
更新日期：2005-03-01 00:00:00
abstract：:Three cases are reported of pyogenic (non-tuberculous) myositis involving the ilio-psoas and/or iliacus muscles in children presenting to John Hunter Hospital, Newcastle, Australia, in a 12-month period. In one, cultures grew Haemophilus influenzae type B and in the other two Staphylococcus aureus was isolated. Biopsy...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00183769
更新日期：1996-03-01 00:00:00
abstract：:A 6-year-old girl presented with intractable constipation. On investigation, she was found to have an association of anorectal stenosis, anterior sacral defect, and anterior meningocoele (Currarino's triad). The meningocoele was excised and a Duhamel pull-through procedure performed after resection of a massively dist...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830050362
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Pediatric patients with medically refractory ulcerative colitis (UC) often undergo an initial subtotal colectomy end ileostomy (STC-I). The role of fecal diversion in the subsequent completion proctectomy/ileal-pouch anal anastomosis (CP-IPAA) remains controversial. METHODS:A multi-institutional retrospecti...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-019-04440-1
更新日期：2019-04-01 00:00:00
abstract：:At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1839-9
更新日期：2007-02-01 00:00:00
abstract：:To evaluate the efficacy of ultrasound (US) guided percutaneous sclerotherapy in the pediatric population, 14 hydatid liver cysts (HLC) in eight male patients whose ages ranged between 6 and 16 years (mean 9.9 years) were treated. The maximum diameter was 110 mm. Albendazole was administered orally to all patients for...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000356
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:Since 1999, complete primary repair of exstrophy has represented a valid alternative in the treatment of exstrophy patients, offering one- stage reconstruction for all components of this malformation in newborns. The vast majority of cases are currently approached within 48/72 h of life, and risk of vascular in...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2745-8
更新日期：2011-04-01 00:00:00
abstract：UNLABELLED:Necrotizing enterocolitis (NEC) is a serious condition with a high morbidity and mortality commonly affecting premature babies. Data for the impact of the long-term disease burden in developing countries are limited although poor long-term outcome of surgically managed patients has been shown in terms of inc...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2583-8
更新日期：2010-04-01 00:00:00
abstract：:The activity of phospholipase A2 (PLA2) is elevated in the intestinal epithelia of patients with inflammatory bowel disease (IBD). We recently reported that PLA2 mediates hydrolysis of phosphatidylcholine (PC) to lysophosphatidylcholine (L-PC) when both are applied to the apical surface of cultured EC monolayers, resu...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830100592
更新日期：2001-05-01 00:00:00
abstract：PURPOSE:The pathophysiology of Hirschsprung's disease (HSCR) is not entirely understood. There is no clear explanation for the occurrence of the spastic or tonically contracted aganglionic segment of bowel. Kv11.1 (hERG) channels play a critical role in the regulation of the resting membrane potential as well as affect...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3807-8
更新日期：2016-01-01 00:00:00
abstract：:Colonic atresia and choledochal cyst are rare congenital abnormalities and there are few cases of their coexistence reported in the literature. We report a case of choledochal cyst and colonic atresia in a term neonate. Our prenatal ultrasonographic and intraoperative findings support the idea that these two entities ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2280-z
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Voltage-gated potassium ion channels have long been implicated in gastrointestinal motility. Recent studies have highlighted the role of voltage-gated channel subfamily G member 3 (KCNG3) and 4 (KCNG4) genes in the electrical functioning of interstitial cells of Cajal and PDGFRα+ cells of the mouse colon. We de...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4394-2
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:to report the early experience with the Kelly procedure for the treatment of bladder exstrophy (BE) in males. MATERIALS AND METHODS:Nine boys with BE were treated at our institute. One had an untouched BE, four had epispadias after neonatal bladder closure, and four were secondary phalloplasties. Data on surgi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2356-4
更新日期：2009-05-01 00:00:00
