MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia.

abstract：:Immunophenotypes and Ig gene rearrangements were investigated in 12 patients with a variant form of hairy cell leukemia (HCL) termed HCL-Japanese variant (HCL-J), and in an HCL-J-derived cell line. The leukemic cells of HCL-J characteristically showed the phenotype of CD20+, CD5-, CD10-, CD11c+, CD22+, CD24- and CD25-...

journal_title：Leukemia

authors： Yamaguchi M,Machii T,Shibayama H,Tokumine Y,Hara J,Yutsudo M,Yamada O,Klobeck HG,Kitani T

更新日期：1996-08-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the nuclear factor (NF)-kappaB pathway. Gastric MALT lymphomas harboring such translocations usually do not respond to Helicobacter pyl...

journal_title：Leukemia

authors： Hamoudi RA,Appert A,Ye H,Ruskone-Fourmestraux A,Streubel B,Chott A,Raderer M,Gong L,Wlodarska I,De Wolf-Peeters C,MacLennan KA,de Leval L,Isaacson PG,Du MQ

更新日期：2010-08-01 00:00:00

abstract：:This phase 1 dose-escalation study evaluated pomalidomide, bortezomib (subcutaneous (SC) or intravenous (IV)) and low-dose dexamethasone (LoDEX) in lenalidomide-refractory and proteasome inhibitor-exposed relapsed or relapsed and refractory multiple myeloma (RRMM). In 21-day cycles, patients received pomalidomide (1-4...

journal_title：Leukemia

authors： Richardson PG,Hofmeister CC,Raje NS,Siegel DS,Lonial S,Laubach J,Efebera YA,Vesole DH,Nooka AK,Rosenblatt J,Doss D,Zaki MH,Bensmaine A,Herring J,Li Y,Watkins L,Chen MS,Anderson KC

更新日期：2017-12-01 00:00:00

abstract：:Expression of the human multidrug resistance 1 gene (MDR1), which encodes the P-glycoprotein transmembrane efflux pump, has been associated with treatment failure of some leukemias, primarily acute myeloid leukemia (AML). To elucidate the epigenetic events associated with overexpression of MDR1 in AML, we analyzed the...

journal_title：Leukemia

authors： Fryxell KB,McGee SB,Simoneaux DK,Willman CL,Cornwell MM

更新日期：1999-06-01 00:00:00

abstract：:Acute myelogenous leukemia (AML) remains a deadly disease for most adult patients, due primarily to the emergence of chemoresistant cells. Defects in apoptosis pathways make important contributions to chemoresistance, suggesting a need to restore apoptosis sensitivity or to identify alternative pathways for apoptosis ...

journal_title：Leukemia

authors： Suh WS,Kim YS,Schimmer AD,Kitada S,Minden M,Andreeff M,Suh N,Sporn M,Reed JC

更新日期：2003-11-01 00:00:00

abstract：:The examples discussed above show the profound influence of HIV infection on expression pattern of cell surface proteins and the functional relevance thereof. Altered cell surface pattern is involved in all aspects of HIV-induced pathogenesis such as viral spreading viral adhesion and cellular apoptosis and is an impo...

journal_title：Leukemia

authors： Speth C,Dierich MP

更新日期：1999-04-01 00:00:00

abstract：:Adults with acute lymphoblastic leukemia (ALL) do worse than children. From 7/2008 to 12/2014, Nordic and Baltic centers treated 1509 consecutive patients aged 1-45 years with Philadelphia chromosome-negative ALL according to the NOPHO ALL2008 without cranial irradiation. Overall, 1022 patients were of age 1-9 years (...

journal_title：Leukemia

authors： Toft N,Birgens H,Abrahamsson J,Griškevičius L,Hallböök H,Heyman M,Klausen TW,Jónsson ÓG,Palk K,Pruunsild K,Quist-Paulsen P,Vaitkeviciene G,Vettenranta K,Åsberg A,Frandsen TL,Marquart HV,Madsen HO,Norén-Nyström U,Schmi

更新日期：2018-03-01 00:00:00

abstract：:The phenotypic expression of genetically determined resistance to radiation leukemia virus (RadLV)-induced leukemia in mice has been shown to reside in the bone marrow. Because the bone marrow contains precursors of natural killer (NK) cells, known to play a role in retrovirally induced infections, and because these c...

journal_title：Leukemia

authors： St-Pierre Y,Hugo P,Lemieux S,Lussier G,Potworowski EF

更新日期：1988-08-01 00:00:00

abstract：:The stem cell leukaemia (SCL) gene is a member of the basic helix-loop-helix family of transcription factors and is essential for the development of all haematopoietic lineages. SCL is expressed in pluripotent haematopoietic stem cells and also following commitment to the erythroid, mast and megakaryocytic lineages. T...

journal_title：Leukemia

authors： Fordham JL,Göttgens B,McLaughlin F,Green AR

更新日期：1999-05-01 00:00:00

abstract：:Sorafenib, a novel drug for metastatic renal cancer, has broad-spectrum activity against multiple tyrosine kinases, including Raf-1, vascular endothelial growth factor receptor and platelet-derived growth factor receptor. However, little is known about its effects on the immune system. In this report, we examine the e...

journal_title：Leukemia

authors： Zhao W,Gu YH,Song R,Qu BQ,Xu Q

更新日期：2008-06-01 00:00:00

abstract：:In this work we have mapped by double-label immunofluorescence the cellular distribution of integrins and their relationship with cytoskeletal proteins in normal and malignant monocytes. In normal monocytes, CD18 and CD11c are concentrated at specific adhesion sites, named podosomes, together with actin, vinculin, and...

journal_title：Leukemia

authors： Gaidano G,Bergui L,Schena M,Gaboli M,Cremona O,Marchisio PC,Caligaris-Cappio F

更新日期：1990-10-01 00:00:00

abstract：:This analysis assessed the effect of lenalidomide on progression-free survival (PFS). Patients with relapsed or refractory multiple myeloma (RRMM) who received lenalidomide plus dexamethasone in the MM-009 and MM-010 trials were pooled and those who had not progressed and were still receiving lenalidomide at 12 months...

journal_title：Leukemia

authors： Dimopoulos MA,Hussein M,Swern AS,Weber D

更新日期：2011-10-01 00:00:00

abstract：:Despite many years of meticulous immunophenotyping of childhood acute lymphoblastic leukaemia (ALL) cases the prognostic significance of some subtypes remains unclear. The Medical Research Council UKALLXI trial (1990-1996) in which uniform treatment has been given to 2090 children with ALL below the age of 18 years an...

journal_title：Leukemia

authors： Hann IM,Richards SM,Eden OB,Hill FG

更新日期：1998-08-01 00:00:00

abstract：:Cellular stressors induce various outcomes including inhibition of cell proliferation and cell death. Sodium salicylate (SA), a plant stress hormone, can suppress the proliferation or cause apoptosis in certain mammalian cancer cells. Plant stress hormones are activators of cellular responses, including cell death, to...

journal_title：Leukemia

authors： Fingrut O,Flescher E

更新日期：2002-04-01 00:00:00

abstract：:Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are frequently found in several human cancer types including acute myeloid leukemia (AML) and lead to the production of high levels of the oncometabolite (R)-2-hydroxyglutarate (R-2HG). Here we report the characterization of BAY1436032, a novel pan-mutant IDH1 ...

journal_title：Leukemia

authors： Chaturvedi A,Herbst L,Pusch S,Klett L,Goparaju R,Stichel D,Kaulfuss S,Panknin O,Zimmermann K,Toschi L,Neuhaus R,Haegebarth A,Rehwinkel H,Hess-Stumpp H,Bauser M,Bochtler T,Struys EA,Sharma A,Bakkali A,Geffers R,Ara

更新日期：2017-10-01 00:00:00

abstract：:Inorganic arsenic trioxide (As(2)O(3)) is a highly effective treatment for acute promyelocytic leukemia (APL). However, other cancers do not respond well to this form of arsenic at clinically achievable doses. We tested a novel arsenical, S-dimethylarsino-glutathione (darinaparsin) for efficacy in various malignancies...

journal_title：Leukemia

authors： Diaz Z,Mann KK,Marcoux S,Kourelis M,Colombo M,Komarnitsky PB,Miller WH Jr

更新日期：2008-10-01 00:00:00

abstract：:CD40 is a surface glycoprotein, member of the nerve growth factor receptor family, which is expressed on B cells and plays an important role in their development, growth, and differentiation. Using chromosomal in situ hybridization, we localized the CD40 gene to the long arm of chromosome 20, bands q12-q13.2. This loc...

journal_title：Leukemia

authors： Lafage-Pochitaloff M,Herman P,Birg F,Galizzi JP,Simonetti J,Mannoni P,Banchereau J

更新日期：1994-07-01 00:00:00

abstract：:Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene have been found at high frequency in cell lines derived from a variety of adult solid tumors. In order to investigate the status of the CDKN2 gene in cell lines established from childhood acute lymphoblastic leukemia (ALL), we surveyed 25 lines representing the maj...

journal_title：Leukemia

authors： Zhou M,Gu L,James CD,He J,Yeager AM,Smith SD,Findley HW

更新日期：1995-07-01 00:00:00

abstract：:Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor. We compared outcomes after UCBT an...

journal_title：Leukemia

authors： Ruggeri A,Labopin M,Sanz G,Piemontese S,Arcese W,Bacigalupo A,Blaise D,Bosi A,Huang H,Karakasis D,Koc Y,Michallet M,Picardi A,Sanz J,Santarone S,Sengelov H,Sierra J,Vincent L,Volt F,Nagler A,Gluckman E,Ciceri F

更新日期：2015-09-01 00:00:00

abstract：:max 41 transgenic mice consistently exhibit elevated numbers of mature granulocytes and monocytes in the peripheral blood and of immature and mature cells of these lineages in the marrow, spleen, lymph nodes and liver. The immature populations are not autonomous and exhibit a normal quantitative responsiveness to prol...

journal_title：Leukemia

authors： Metcalf D,Roberts AW,Willson TA

更新日期：1996-02-01 00:00:00

abstract：:Single-colony karyotyping (SCK) and reverse-transcription polymerase chain reaction (RT-PCR) are two increasingly used techniques for the quantification of leukemic colonies generated by chronic myelogenous leukemia (CML) cell fractions purged or selected in vitro. Recently, the existence of Philadelphia (Ph) chromoso...

journal_title：Leukemia

authors： Savoldo B,Sammarelli G,Dotti G,Garau D,Regazzi E,Cilloni D,Tabilio A,Rizzoli V,Carlo-Stella C

更新日期：1998-03-01 00:00:00

abstract：:Surface phenotypes and genotypes of six T cell lines established from four patients with adult T cell leukemia (ATL) were compared with those of fresh ATL cells. The surface antigen densities of CD3 and T cell receptor (TCR) complex examined by OKT3 and WT-31 mAbs on fresh ATL cells were low. But three IL-2-dependent ...

journal_title：Leukemia

authors： Shirono K,Hattori T,Matsuoka M,Matsushita S,Asou N,Takatsuki K

更新日期：1988-11-01 00:00:00

abstract：:The unbalanced translocation, der(1;7)(q10;p10), is one of the characteristic cytogenetic abnormalities found in myelodysplastic syndromes (MDS) and other myeloid neoplasms. Although described frequently with very poor clinical outcome and possible relationship with monosomy 7 or 7q- (-7/7q-), this recurrent cytogenet...

journal_title：Leukemia

authors： Sanada M,Uike N,Ohyashiki K,Ozawa K,Lili W,Hangaishi A,Kanda Y,Chiba S,Kurokawa M,Omine M,Mitani K,Ogawa S

更新日期：2007-05-01 00:00:00

abstract：:A case of an infant male with Down's syndrome, pancytopenia, and a relative lymphocytosis is presented. A bone marrow aspirate and crushed marrow biopsy were evaluated by microscopy and flow cytometry. A population of immature lymphoid cells positive for CD10 (CALLA) and CD19 (Leu 12) was initially interpreted as sugg...

journal_title：Leukemia

authors： Richard G,Brody J,Sun T

更新日期：1993-11-01 00:00:00

abstract：:We applied a new strategy for the detection of N-ras gene mutations based on LightCycler technology. We designed two sets of amplimers and internal hybridization probes representing N-ras codons 12/13 and codon 61, respectively. Genomic DNAs from 134 childhood acute lymphoblastic leukemia (ALL) patients (83 common ALL...

journal_title：Leukemia

authors： Nakao M,Janssen JW,Seriu T,Bartram CR

更新日期：2000-02-01 00:00:00

abstract：:A phase III clinical trial was developed to test whether the addition of etoposide to a high-dose cytosine arabinoside regimen would improve the remission rate, duration of remission, and survival in relapsed and refractory patients with acute myelogenous leukemia. One hundred and thirty-one patients stratified by age...

journal_title：Leukemia

authors： Vogler WR,McCarley DL,Stagg M,Bartolucci AA,Moore J,Martelo O,Omura GA

更新日期：1994-11-01 00:00:00

abstract：:The t(9;22)(q34;q11), generating the Philadelphia chromosome (Ph), is found in more than 90% of patients with chronic myeloid leukemia (CML) and in 15-30% of adults with acute lymphoblastic leukemia (ALL). Different groups have recently described the presence of large genomic deletions adjacent to the translocation br...

journal_title：Leukemia

authors： Specchia G,Albano F,Anelli L,Storlazzi CT,Zagaria A,Mancini M,Cuneo A,Pane F,Foà R,Manolelli F,Liso V,Rocchi M

更新日期：2003-03-01 00:00:00

abstract：:Hemizygous deletions are common molecular abnormalities in cancer. In some cases, these deletions highlight chromosomal loci containing tumor suppressor genes that undergo homozygous inactivation. In other cases, hemizygous deletions cause disease by allelic insufficiency for one or more genes. As the intact allele ha...

journal_title：Leukemia

authors： Ebert BL

更新日期：2009-07-01 00:00:00

abstract：:Arsenic trioxide (ATO) induces disease remission in acute promyelocytic leukemia (APL) patients, but not in non-APL acute myeloid leukemia (AML) patients. ATO at therapeutic concentrations (1-2 μM) induces APL NB4, but not non-APL HL-60, cells to undergo apoptosis through the mitochondrial pathway. The role of antiapo...

journal_title：Leukemia

authors： Wang R,Xia L,Gabrilove J,Waxman S,Jing Y

更新日期：2013-02-01 00:00:00

abstract：:We studied changes in peripheral blood and bone marrow biopsy specimens obtained before, during, and after recombinant alpha 2b-interferon (IFN-alpha 2b) therapy in 25 patients with hairy cell leukemia. During therapy, only 1 patient showed no improvement in at least one of the parameters monitored. Granulocytopenia, ...

journal_title：Leukemia

authors： Bardawil RG,Ratain MJ,Golomb HM,Bitter MA,Groves C,Vardiman JW

更新日期：1987-04-01 00:00:00