Abstract：
:This analysis assessed the effect of lenalidomide on progression-free survival (PFS). Patients with relapsed or refractory multiple myeloma (RRMM) who received lenalidomide plus dexamethasone in the MM-009 and MM-010 trials were pooled and those who had not progressed and were still receiving lenalidomide at 12 months were included. The median follow-up of surviving patients was 48 months. Of 353 patients who received lenalidomide plus dexamethasone, 116 (33%) had not progressed. Overall, 52 patients (45%) had no dose reductions, 25 (22%) had dose reductions ≥12 months and 39 (34%) had dose reductions before 12 months. Patients who had dose reductions ≥12 months had a significantly longer median PFS than those who had reductions before 12 months (P=0.007) or no dose reductions (P=0.039) (not reached vs 28.0 vs 36.8 months, respectively). In a multivariate Cox regression model, dose reduction ≥12 months was an independent predictor of improved PFS (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98) after adjusting for patient characteristics. The data suggest that to achieve maximum PFS benefit, patients with RRMM should be treated for ≥12 months with full-dose lenalidomide plus dexamethasone. Thereafter, patients may benefit from lower-dose continued therapy; prospective studies are needed to confirm these findings.
journal_name
Leukemiajournal_title
Leukemiaauthors
Dimopoulos MA,Hussein M,Swern AS,Weber Ddoi
10.1038/leu.2011.126subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1620-6issue
10eissn
0887-6924issn
1476-5551pii
leu2011126journal_volume
25pub_type
杂志文章相关文献
LEUKEMIA文献大全abstract：:G-CSF-induced myeloid differentiation of 32Dcl3 murine myeloblast cells is antagonized by concurrent exposure to interleukin-3 (IL-3) or by oncogenic transformation of 32Dcl3 by src- or abl-oncogenes which render the cells IL-3-independent. Recent reports have linked G-CSF-mediated differentiation to the ability of G-...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401253
更新日期：1999-01-01 00:00:00
abstract：:In this study, we compared immunoglobulin heavy-chain-gene-based minimal residual disease (MRD) detection by real-time quantitative PCR (RQ-PCR) and next-generation sequencing (NGS) to assess whether NGS could overcome some limitations of RQ-PCR and further increase sensitivity, specificity, accuracy and reproducibili...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2013.375
更新日期：2014-06-01 00:00:00
abstract：:Bone marrow cells from most patients with acute promyelocytic leukemia contain a highly specific cytogenetic rearrangement, a reciprocal translocation between the long arms of chromosomes 15 and 17. Several cases of variant translocations involving 17q but not 15q have been reported, leading to the suggestion that the...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Despite the presence of tumor antigens, the paucity of clinically significant T-cell mediated immune responses against human tumors is striking. This may, in part, be because of the inability of cancer cells to function as efficient antigen-presenting cells. For full activation, T cells must receive two signals delive...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：:Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders found predominantly in the elderly. The molecular mechanisms underlying the development of MDS remain obscure. In order to begin to identify tumor suppressor genes involved in these disorders, we performed a detailed microsatellite allelotype ...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401717
更新日期：2000-05-01 00:00:00
abstract：:The p21MDA6 gene product induces cell cycle arrest in p53-null human leukemic cells exposed to differentiation stimuli. We employed an HL-60 cell line stably transfected with a p21MDA6 antisense construct to compare the effects of p21MDA6 dysregulation on the response of myeloid leukemia cells to differentiating and c...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400625
更新日期：1997-04-01 00:00:00
abstract：:The retinoic acid receptor-alpha (RAR-alpha) gene was previously localized to chromosome 17q21, a region close to the t(15;17) (q22;q21) abnormality in acute promyelocytic leukemia (APL). We used the RAR-alpha gene as a probe and found that eight of nine APL patient samples with t(15;17) (q22;q21) showed rearranged ba...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Chronic lymphocytic leukemia (CLL) is a progressive disease in which chemotherapy may result in temporary suppression of the peripheral blood lymphocyte count, but cure is not usually possible. Drug resistance mechanisms and the multidrug resistant (MDR) phenotype may be relevant to the therapeutic response. We have s...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heterogenous genomic landscape. Copy number and structural changes due to chromosomal instability (CIN) are common features of MM. In this review, we describe how primary and secondary genetic event...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/s41375-020-0921-y
更新日期：2020-11-01 00:00:00
abstract：:The t(9;11)(p21;q23) has been associated with characteristic clinical features and a superior treatment outcome in previously untreated pediatric acute myeloblastic leukemia (AML), but has not been well studied in children with secondary AML. This translocation was detected in 6.7% of de novo and 46% of secondary AML ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant m...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/s41375-020-0887-9
更新日期：2020-07-01 00:00:00
abstract：:We analyzed the TS-2 acute lymphoblastic leukemia (ALL) cell line that contains a t(1;19)(q23;p13.3) but lacks E2A-PBX1 fusion typically present in leukemias with this translocation. We found that the t(1;19) in TS-2 fuses the 19p13 gene DAZAP1 (Deleted in Azoospermia-Associated Protein 1) to the 1q23 gene MEF2D (Myoc...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403684
更新日期：2005-05-01 00:00:00
abstract：:Ikaros family zinc finger protein 1 and 3 (IKZF1 and IKZF3) are transcription factors that promote multiple myeloma (MM) proliferation. The immunomodulatory imide drug (IMiD) lenalidomide promotes myeloma cell death via Cereblon (CRBN)-dependent ubiquitylation and proteasome-dependent degradation of IKZF1 and IKZF3. A...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/s41375-019-0403-2
更新日期：2019-08-01 00:00:00
abstract：:Cladribine has been reported to have little activity in fludarabine- refractory chronic lymphocytic leukemia (CLL). We sought to determine whether resistance to therapy with cladribine in fludarabine-refractory CLL patients represented primary drug resistance or the inability to tolerate the myelosuppression associate...
journal_title：Leukemia
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.leu.2402752
更新日期：2003-02-01 00:00:00
abstract：:Deletions from the derivative chromosome 9, der(9), of the translocation, t(9;22)(q34;q11), at the site of the ABL/BCR fusion gene, have been demonstrated by fluorescence in situ hybridisation (FISH), in both Philadelphia chromosome (Ph)-positive chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL)....
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2403629
更新日期：2005-04-01 00:00:00
abstract：:Previously, we identified SETD2 loss-of-function mutations in 22% of MLL-rearranged (MLLr) acute leukemia patients, implicating a mechanism for cooperativity between SETD2 mutations and MLL fusions. However, the detailed mechanism of how SETD2-H3K36me3 downregulation accelerates MLLr leukemia remains unclear. Here, we...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2017.339
更新日期：2018-04-01 00:00:00
abstract：:CD44 variant isoforms (CD44v) have been shown to be important factors in adverse prognosis in hematological malignancies. To investigate whether CD44 expression is associated with malignant transformation in multiple myeloma, RNA and protein expression of CD44 standard (CD44s) and CD44v4, v6, v9, v10 containing isofor...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401179
更新日期：1998-11-01 00:00:00
abstract：:Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. Since P-glycoprotein (P-gp) encoded by the MDR-1 gene plays a key role in MDR, many P-gp-specific monoclonal antibodies (MAbs) have been generated for characterization and analysis of P-gp. Among those antibodies, MRK16 has bee...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/sj.leu.2400658
更新日期：1997-07-01 00:00:00
abstract：:A consecutive population-based series of 372 adult acute myeloid leukemias, successfully cytogenetically investigated at a single center between 1976 and 1993, is reported. All medical records were reviewed in order to ascertain the prognostic impact of karyotype, divided into three groups; favorable (t(8;21), t(15;17...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2401788
更新日期：2000-06-01 00:00:00
abstract：:Normal human myeloid cells require certain colony stimulating factors (CSFs) for growth and differentiation. These CSFs are normally produced exogenously by accessory cells. However, human acute myeloid leukemia cells have been found, in certain instances, to have constitutive, endogenous production of one or more of ...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Currently available data on chimeric antigen receptor (CAR)-T cell therapy has demonstrated efficacy and manageable toxicity in heavily pretreated multiple myeloma (MM) patients. The CAR-T field in MM is rapidly evolving with >50 currently ongoing clinical trials across all phases, different CAR-T design, or targets. ...
journal_title：Leukemia
pub_type： 杂志文章,评审
doi：10.1038/s41375-020-0930-x
更新日期：2020-09-01 00:00:00
abstract：:HOX homeobox proteins are key oncogenic drivers in hematopoietic malignancies. Here we demonstrate that HOXA1, HOXA6 and predominantly HOXA9 are able to induce the production of insulin-like growth factor 1 (Igf1). In chromatin immunoprecipitations, HOXA9 bound directly to the putative promoter and a DNase-hypersensit...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2014.287
更新日期：2015-04-01 00:00:00
abstract：:Xenotransplantation of human acute myeloid leukemia (AML) in immunocompromised animals has been critical for defining leukemic stem cells. However, existing immunodeficient strains of mice have short life spans and low levels of AML cell engraftment, hindering long-term evaluation of primary human AML biology. A recen...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2009.143
更新日期：2009-11-01 00:00:00
abstract：:It is well documented that the calcitonin gene area in the short arm of chromosome 11 is hypermethylated in most acute leukemias as well as in chronic lymphatic leukemia. In contrast, the gene is normally methylated during the chronic phase of the chronic myeloid leukemia but turns hypermethylated as the disease escal...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:We describe two new human leukemia cell lines, MOLM-13 and MOLM-14, established from the peripheral blood of a patient at relapse of acute monocytic leukemia, FAB M5a, which had evolved from myelodysplastic syndrome (MDS). Both cell lines express monocyte-specific esterase (MSE) and MLL-AF9 fusion mRNA. Gene fusion is...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/sj.leu.2400768
更新日期：1997-09-01 00:00:00
abstract：:Monoclonal antibody (mAb) M195 is a mouse IgG2a reactive with a myelomonocytic differentiation antigen found on early myeloid cells and monocytes. The reactivity of M195 with fresh hematopoietic neoplasms in the blood or bone marrow from 227 patients at Memorial Hospital was determined by flow cytometry. M195 was posi...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:A lot of genes deregulated in malignant plasma cells (PCs) involved in multiple myeloma have been reported these last years. The expression of some of these genes is associated with poor survival. A critical step is to elucidate the biological mechanisms triggered by these gene products. Such studies are hampered by t...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2012.36
更新日期：2012-07-01 00:00:00
abstract：:Human cytomegalovirus (CMV) infections and relapse of disease remain major problems after allogeneic stem cell transplantation (allo-SCT), in particular in combination with CMV-negative donors or cordblood transplantations. Recent data suggest a paradoxical association between CMV reactivation after allo-SCT and reduc...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2012.374
更新日期：2013-06-01 00:00:00
abstract：:The polymerase chain reaction (PCR) cannot be used to amplify the breakpoint in the chimaeric BCR-ABL gene in CML and acute leukaemias due to the large variation in the sites of breakpoint in the BCR gene (within a 5.8 kb region) and in the ABL gene (within a 150 kb region). The disease state is usually monitored usin...
journal_title：Leukemia
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by chronic proliferation of hematopoietic progenitors. We studied the telomere length (TL) of 335 MPN patients and 93 gender- and age-matched controls using a quantitative PCR method (relative TL calculated as the ratio of the amount of t...
journal_title：Leukemia
pub_type： 杂志文章
doi：10.1038/leu.2008.319
更新日期：2009-02-01 00:00:00
