Abstract:
:This systematic review summarizes and critically appraises the literature on the effect of erythropoietin (EPO) in schizophrenia patients and the pathophysiological mechanisms that may explain the potential of its use in this disease. EPO is mainly known for its regulatory activity in the synthesis of erythrocytes and is frequently used in treatment of chronic anemia. This cytokine, however, has many other properties, some of which may improve the symptoms of psychiatric illness. The review follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement guidelines. Three databases (Medline, Web of Science, and Cochrane) were searched combining the search terms 'erythropoietin AND (psychotic disorders OR schizophrenia)'. Seventy-eight studies were included in qualitative synthesis, a meta-analytic approach being prohibited. The findings suggest that several EPO cerebral potential properties may be relevant for schizophrenia treatment, such as neurotransmission regulation, neuroprotection, modulation of inflammation, effects on blood-brain barrier permeability, effects on oxidative stress and neurogenesis. Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO. Overall, because the available data are inconclusive, further efforts in this field are warranted.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Fond G,Macgregor A,Attal J,Larue A,Brittner M,Ducasse D,Capdevielle Ddoi
10.1111/j.1440-1819.2012.02359.xsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
375-82issue
5eissn
1323-1316issn
1440-1819journal_volume
66pub_type
杂志文章,评审abstract:AIM:Atypical antipsychotic treatment (e.g. risperidone) has been found to improve social functioning more than standard antipsychotic treatment. However, it is unclear which specific social behaviors are implicated in this improvement. The current study employed an interactive puzzle game to examine how social behavior...
journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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更新日期:2020-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,评审
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