CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival.

abstract：:We have compared the pattern of surface antigen expression, as detected by monoclonal antibodies (mAbs), in plasma membranes vs shed membrane vesicles of two human breast carcinoma cell lines, MCF-7 and 8701-BC. Antigen expression was detected on cells by immunofluorescence (IF) analysis, whilst, due to their small di...

journal_title：Clinical & experimental metastasis

authors： Dolo V,Adobati E,Canevari S,Picone MA,Vittorelli ML

更新日期：1995-07-01 00:00:00

abstract：:Lung cancer is the most frequent and one of the most deadly cancer types and is classified into small cell lung cancer and non-small cell lung cancer (NSCLC). Transforming growth factor beta (TGFβ) regulates a wide array of cell functions and plays a major role in lung diseases, including NSCLC. TGFβ signals through t...

journal_title：Clinical & experimental metastasis

authors： Vázquez PF,Carlini MJ,Daroqui MC,Colombo L,Dalurzo ML,Smith DE,Grasselli J,Pallotta MG,Ehrlich M,Bal de Kier Joffé ED,Puricelli L

更新日期：2013-12-01 00:00:00

abstract：:The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease systems, which destroy the extracellular matrix (ECM), in order to enable the invading cells to simultaneously grip and destroy the anatomical barriers that co...

journal_title：Clinical & experimental metastasis

authors： Del Rosso M,Fibbi G,Pucci M,D'Alessio S,Del Rosso A,Magnelli L,Chiarugi V

更新日期：2002-01-01 00:00:00

abstract：:We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients diagnosed with primary synchronous metastatic rectal cancer between 1992 and 2008 in the Eindhoven Cancer Registry area were included. Date of diagnosis was divided into three periods (1992-19...

journal_title：Clinical & experimental metastasis

authors： Lemmens VE,de Haan N,Rutten HJ,Martijn H,Loosveld OJ,Roumen RM,Creemers GJ

更新日期：2011-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor with a key role in many physiological and pathological processes. Investigation into the implications of circulating levels of this cytokine is progressing at an exponential rate. However, there are important inconsistencies between reports...

journal_title：Clinical & experimental metastasis

authors： Hormbrey E,Gillespie P,Turner K,Han C,Roberts A,McGrouther D,Harris AL

更新日期：2002-01-01 00:00:00

abstract：:Intravenous infusions of perfluorochemical emulsions, combined with administration of inspired oxygen or carbogen have been found to improve tumor oxygenation and increase the response of solid tumors in animals to radiotherapy. Fluosol-DA 20 per cent, the only perfluorochemical emulsion currently approved for testing...

journal_title：Clinical & experimental metastasis

authors： Rockwell S,Irvin CG,Nierenburg M

更新日期：1986-01-01 00:00:00

abstract：:Two new compounds, 4-[4-[bis-(2-chloroethyl)-amino-]phenyl]-1- hydroxybutane-1,1-bisphosphonic acid (BAD) and aminotris-(methylenephosphonato)-diamminoplatinum(II) (ADP) that both have cytostatic and osteotropic properties, have shown good therapeutic efficacy against an osteosarcoma which metastasizes and kills by lu...

journal_title：Clinical & experimental metastasis

authors： Klenner T,Wingen F,Keppler B,Valenzuela-Paz P,Amelung F,Schmähl D

更新日期：1990-07-01 00:00:00

abstract：:The purpose of this study was to determine the subpopulation dynamics of human colon carcinoma (HCC) cells growing at orthotopic (cecum, liver) or ectopic (subcutis, kidney, spleen) sites in nude mice and to correlate any outgrowth of distinct clones with the differential expression of metastasis-related genes. Low me...

journal_title：Clinical & experimental metastasis

authors： Singh RK,Tsan R,Radinsky R

更新日期：1997-03-01 00:00:00

abstract：:Two widely used B16 melanoma cell lines of low and high lung colonizing potential (B16-F1 and B16-F10) were compared in their ability to induce platelet aggregation. The results of these experiments showed a reproducible difference in platelet aggregating activity of these two cell lines which directly correlated with...

journal_title：Clinical & experimental metastasis

authors： Kimura AK,Mehta P,Xiang JH,Lawson D,Dugger D,Kao KJ,Lee-Ambrose L

更新日期：1987-04-01 00:00:00

abstract：:We have previously reported that transfection of mouse interferon gamma (IFN-gamma) in H-2Kk-positive BW variants (BW-Sp3) abolishes tumorigenicity and reduces metastatic capacity. To further increase the immunogenicity of BW-Sp3 cells, the gene for human interleukin 2 (huIL-2) was transfected in these cancer cells. S...

journal_title：Clinical & experimental metastasis

authors： Geldhof AB,Van Ginderachter J,Vandersteen P,Raes G,De Baetselier P

更新日期：1998-07-01 00:00:00

abstract：:The colon carcinoma cell line HT-29 was used to explore the potential of interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) to modify integrin expression and adhesive functions of tumor cells in vitro and to examine corresponding metastatic effects in vivo. Preincubation of HT-29 cells with 100 U/ml of I...

journal_title：Clinical & experimental metastasis

authors： Herzberg F,Schöning M,Schirner M,Topp M,Thiel E,Kreuser ED

更新日期：1996-03-01 00:00:00

abstract：:RGD-containing substrates were used to study static and hydrodynamic adhesion of murine RAW117 large-cell lymphoma sublines with differential liver-metastatic potentials. Highly liver-metastatic RAW117-H10 cells had higher rates of static adhesion to vitronectin, fibronectin and (GRGDS)4 than poorly metastatic RAW117-...

journal_title：Clinical & experimental metastasis

authors： Yun Z,Smith TW,Menter DG,McIntire LV,Nicolson GL

更新日期：1997-01-01 00:00:00

abstract：:Cell motility is an important factor in the process of invasion and metastasis of tumor. In this study, the relationship between cell motility and experimental metastatic potential was examined using two human pancreatic cancer cell lines, SW1990 and PANC-1. Serum-free conditioned medium from the highly metastatic cel...

journal_title：Clinical & experimental metastasis

authors： Sakurai Y,Sawada T,Chung YS,Funae Y,Sowa M

更新日期：1997-05-01 00:00:00

abstract：:Bone is the third most common site of cancer metastasis. Over 30 to 40% of lung cancers can develop skeletal metastasis and no effective curative therapy exists in clinic cases. Previously we screened the different expression of proteins between SBC-5 cells and SBC-3 cells by proteomic study methods (MALDI-TOF/TOF-MS)...

journal_title：Clinical & experimental metastasis

authors： Ma NQ,Liu LL,Min J,Wang JW,Jiang WF,Liu Y,Feng YG,Su HC,Feng YM,Zhang HL

更新日期：2011-12-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved sys...

journal_title：Clinical & experimental metastasis

authors： Thiagarajan A,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:GPR56, a non-classical adhesion receptor, was previously reported to suppress tumor growth and metastasis in xenograft models using human melanoma cell lines. To understand whether GPR56 plays similar roles in the development of endogenous tumors, we analyzed cancer progression in Gpr56 (-/-) mice using a variety of t...

journal_title：Clinical & experimental metastasis

authors： Xu L,Begum S,Barry M,Crowley D,Yang L,Bronson RT,Hynes RO

更新日期：2010-04-01 00:00:00

abstract：:CNTO 95 is a fully human monoclonal antibody that recognizes alphav integrins. Previous studies have shown that CNTO 95 exhibits both anti-tumor and anti-angiogenic activities (Trikha M et al., Int J Cancer 110:326-335, 2004). In this study we investigated the biological activities of CNTO 95 on breast tumor cells bot...

journal_title：Clinical & experimental metastasis

authors： Chen Q,Manning CD,Millar H,McCabe FL,Ferrante C,Sharp C,Shahied-Arruda L,Doshi P,Nakada MT,Anderson GM

更新日期：2008-01-01 00:00:00

abstract：:As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were evaluated in cell-based assays for proliferation, adhesion, migration, invasion, anchorage-independent growth, angiogenesis, mineralised nodule formation, plasmid transfection and oligonucleotide transfection. Tumor ta...

journal_title：Clinical & experimental metastasis

authors： Dass CR,Ek ET,Contreras KG,Choong PF

更新日期：2006-01-01 00:00:00

abstract：:The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly hig...

journal_title：Clinical & experimental metastasis

authors： Volm M,van Kaick G,Mattern J

更新日期：1994-07-01 00:00:00

abstract：:It is recognised that stromal cells determine cancer progression. We have previously shown that active TGFbeta produced by rat colon carcinoma cells modulated NO production in rat endothelial cells. To elucidate the role of TGFbeta and NO in the mechanisms of interaction of colon carcinoma cells with stromal cells and...

journal_title：Clinical & experimental metastasis

authors： Lohm S,Peduto-Eberl L,Lagadec P,Renggli-Zulliger N,Dudler J,Jeannin JF,Juillerat-Jeanneret L

更新日期：2005-01-01 00:00:00

abstract：:The growth of metastatic prostate cancer cells in the bone involves an intimate interaction between the tumor cells and various elements of the bone microenvironment, resulting in increased rate of bone turnover and rapid tumor growth. The alpha(v)beta3 integrin has been shown to play an important role in tumor growth...

journal_title：Clinical & experimental metastasis

authors： Nemeth JA,Cher ML,Zhou Z,Mullins C,Bhagat S,Trikha M

更新日期：2003-01-01 00:00:00

abstract：:The mechanisms that control the insidiously invasive nature of malignant gliomas are poorly understood, and their study would be facilitated by an in vivo model that is easy to manipulate and inexpensive. The developing chick embryo brain was assessed as a new xenograft model for the production, growth, and study of h...

journal_title：Clinical & experimental metastasis

authors： Cretu A,Fotos JS,Little BW,Galileo DS

更新日期：2005-01-01 00:00:00

abstract：:We have used 5'-deoxy-5'-S isobutyl-thioadenosine (SIBA), an analog of S-adenosylhomocysteine, alone or in association with a methionine-depleted diet in order to obtain an antitumoral effect in two different tumor models: a transplantable rat rhabdomyosarcoma (RMS-J1) induced by i.m. injection of nickel and the well-...

journal_title：Clinical & experimental metastasis

authors： Breillout F,Poupon MF,Blanchard P,Lascaux V,Echinard-Garin P,Robert-Gero M

更新日期：1988-01-01 00:00:00

abstract：:The combined therapeutic effect of natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer) and IL-12 against highly metastatic B16-BL6-HM melanoma cells was investigated. In comparison with a single administration of alpha-GalCer or IL-12, the combined treatment of tumor-bearing mice with alpha-GalC...

journal_title：Clinical & experimental metastasis

authors： Nakui M,Ohta A,Sekimoto M,Sato M,Iwakabe K,Yahata T,Kitamura H,Koda T,Kawano T,Makuuchi H,Taniguchi M,Nishimura T

更新日期：2000-01-01 00:00:00

abstract：:Experimental hepatic metastasis of colorectal tumors is frequently studied by local intrahepatic tumor cell implantation. However, although a variety of factors of the implantation procedure may markedly influence tumor growth characteristics, standards are not defined yet. Herein, we studied the effect of different m...

journal_title：Clinical & experimental metastasis

authors： Kollmar O,Schilling MK,Menger MD

更新日期：2004-01-01 00:00:00

abstract：:We investigated the role of signal transduction systems in the attachment of human uveal melanoma cells to matrix proteins. Ocular melanoma cells established from primary tumours attached rapidly to all substrates examined. Preferred substrates of attachment were collagens type I, III and IV and fibronectin rather tha...

journal_title：Clinical & experimental metastasis

authors： Mac Neil S,Wagner M,Rennie IG

更新日期：1994-11-01 00:00:00

abstract：:The cancer preventive properties of grape products such as red wine have been attributed to polyphenols enriched in red wine. However, much of the studies on cancer preventive mechanisms of grape polyphenols have been conducted with individual compounds at concentrations too high to be achieved via dietary consumption...

journal_title：Clinical & experimental metastasis

authors： Castillo-Pichardo L,Martínez-Montemayor MM,Martínez JE,Wall KM,Cubano LA,Dharmawardhane S

更新日期：2009-01-01 00:00:00

abstract：:Use of heparin derivatives in several cancer types revealed that anticoagulant therapies have a beneficiary side effect: delay of tumor progression. Since there are no data on human melanoma, we have analyzed the effect of heparins in preclinical models. Neither unfractionated heparin (UFH), nor its low molecular weig...

journal_title：Clinical & experimental metastasis

authors： Bereczky B,Gilly R,Rásó E,Vágó A,Tímár J,Tóvári J

更新日期：2005-01-01 00:00:00

abstract：:Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas. We show here that KiSS1 is also a metastasis suppressor in human ovarian cancer. Ov...

journal_title：Clinical & experimental metastasis

authors： Jiang Y,Berk M,Singh LS,Tan H,Yin L,Powell CT,Xu Y

更新日期：2005-01-01 00:00:00

abstract：:Metastasis remains the major cause of therapeutic failure, poor prognosis and high mortality in breast and prostate cancer patients. Aberrant microenvironments including hypoxia and acidic pH are common features of most solid tumors that have been long associated with enhanced metastasis and poor patient outcomes. Nov...

journal_title：Clinical & experimental metastasis

authors： Sudhan DR,Siemann DW

更新日期：2013-10-01 00:00:00