Abstract:
BACKGROUND:The prognosis of patients with metastatic breast cancer who have failed to respond to at least two different chemotherapy regimens is poor. Such patients with metastatic disease to the liver have even worse prognosis. Cisplatin and 5-fluorouracil (5-FU) can be given in patients with impaired hepatic function but their combination has not been extensively studied in this setting. PATIENTS AND METHODS:We retrospectively collected data from our registry on patients with advanced metastatic breast cancer who received combination of cisplatin/5-FU. We sought to determine the toxicity, the response rate, the disease control rate and the survival of this combination. RESULTS:We identified 25 heavily pre-treated patients, out of which 19 (76%) had liver metastases. They had been treated before with a median of three lines of cytotoxic chemotherapy. The majority of patients had also received hormonal manipulation or trastuzumab. The median number of cisplatin/5-FU administered cycles, without toxic deaths or unexpected toxicities was four. The partial response (PR) rate was 32% and the disease control rate (DCR) was 68%. The time to progression was five months and the median survival after starting on cisplatin/5-FU was six months. CONCLUSION:The combination of cisplatin/5-FU is active and safe in heavily pre-treated patients with metastatic breast cancer even in the presence of liver metastases and jaundice.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Lekakis L,Tryfonopoulos D,Pistamatzian N,Panopoulos C,Koumakis G,Demiri S,Efremidis Asubject
Has Abstractpub_date
2012-05-01 00:00:00pages
1833-7issue
5eissn
0250-7005issn
1791-7530pii
32/5/1833journal_volume
32pub_type
杂志文章abstract:BACKGROUND/AIM:The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. PATIEN...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.13713
更新日期:2019-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Late developing breast cancer metastases are common and lethal despite treatment with adjuvant chemotherapy at the time of primary tumor excision. Stimulation of an antitumor immune response is an alternative strategy for preventing this devastating development. MATERIALS AND METHODS:A mouse model of the hu...
journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Anticancer research
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pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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