Abstract:
PURPOSE:Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney Injury Network (AKIN) criteria, in critically ill trauma patients. MATERIALS AND METHODS:A prospective cohort of 400 patients admitted to the intensive care unit of a level 1 trauma center was followed for the development of AKI over 5 days. RESULTS:Acute kidney injury developed in 147 (36.8%) of 400 patients. In multivariable regression analysis, independent risk factors for AKI included African American race (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.08-3.18; P = .024), body mass index of 30 kg/m(2) or greater (OR, 4.72 versus normal body mass index; 95% CI, 2.59-8.61; P < .001), diabetes mellitus (OR, 3.26; 95% CI, 1.30-8.20; P = .012), abdominal Abbreviated Injury Scale score of 4 or more (OR, 3.78; 95% CI, 1.79-7.96; P < .001), and unmatched packed red blood cells administered during resuscitation (OR, 1.13 per unit; 95% CI, 1.04-1.23; P = .004). Acute Kidney Injury Network stages 1, 2, and 3 were associated with hospital mortality rates of 9.8%, 13.7%, and 30.4%, respectively, compared with 3.8% for those without AKI (P < .001). CONCLUSIONS:Acute kidney injury in critically ill trauma patients is associated with substantial mortality. The findings of African American race, obesity, and blood product administration as independent risk factors for AKI deserve further study to elucidate underlying mechanisms.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Shashaty MG,Meyer NJ,Localio AR,Gallop R,Bellamy SL,Holena DN,Lanken PN,Kaplan S,Yarar D,Kawut SM,Feldman HI,Christie JDdoi
10.1016/j.jcrc.2012.02.002subject
Has Abstractpub_date
2012-10-01 00:00:00pages
496-504issue
5eissn
0883-9441issn
1557-8615pii
S0883-9441(12)00055-Xjournal_volume
27pub_type
杂志文章abstract:PURPOSE:We wanted to identify the importance of the duration of invasive ventilation and of renal replacement therapy for short-term prognosis of surgical patients treated in an intensive care unit (ICU). METHODS:We analyzed adult patients (n = 1462) who had an ICU length of stay of more than 4 days and who were follo...
journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of critical care
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.02.021
更新日期:2017-08-01 00:00:00
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更新日期:2018-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2014.03.023
更新日期:2014-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1053/jcrc.2002.33032
更新日期:2002-03-01 00:00:00
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journal_title:Journal of critical care
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doi:10.1016/j.jcrc.2005.06.005
更新日期:2005-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:Journal of critical care
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doi:10.1016/j.jcrc.2015.08.010
更新日期:2015-12-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2015.03.013
更新日期:2015-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2007.09.006
更新日期:2008-12-01 00:00:00
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journal_title:Journal of critical care
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doi:10.1053/jcrc.2000.16460
更新日期:2000-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2014.11.003
更新日期:2015-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2007.11.011
更新日期:2008-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2015.01.023
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To assess the clinical significance of serial troponin I levels (measured in the first 72 hours from admission) in 42 consecutive patients with moderate-to-severe acute respiratory distress syndrome (ARDS). Echocardiography and electrocardiogram testings were serially performed in the time window. MATERIALS AN...
journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,评审
doi:10.1016/0883-9441(95)90004-7
更新日期:1995-09-01 00:00:00