African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients.

Abstract:

PURPOSE:Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney Injury Network (AKIN) criteria, in critically ill trauma patients. MATERIALS AND METHODS:A prospective cohort of 400 patients admitted to the intensive care unit of a level 1 trauma center was followed for the development of AKI over 5 days. RESULTS:Acute kidney injury developed in 147 (36.8%) of 400 patients. In multivariable regression analysis, independent risk factors for AKI included African American race (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.08-3.18; P = .024), body mass index of 30 kg/m(2) or greater (OR, 4.72 versus normal body mass index; 95% CI, 2.59-8.61; P < .001), diabetes mellitus (OR, 3.26; 95% CI, 1.30-8.20; P = .012), abdominal Abbreviated Injury Scale score of 4 or more (OR, 3.78; 95% CI, 1.79-7.96; P < .001), and unmatched packed red blood cells administered during resuscitation (OR, 1.13 per unit; 95% CI, 1.04-1.23; P = .004). Acute Kidney Injury Network stages 1, 2, and 3 were associated with hospital mortality rates of 9.8%, 13.7%, and 30.4%, respectively, compared with 3.8% for those without AKI (P < .001). CONCLUSIONS:Acute kidney injury in critically ill trauma patients is associated with substantial mortality. The findings of African American race, obesity, and blood product administration as independent risk factors for AKI deserve further study to elucidate underlying mechanisms.

journal_name

J Crit Care

journal_title

Journal of critical care

authors

Shashaty MG,Meyer NJ,Localio AR,Gallop R,Bellamy SL,Holena DN,Lanken PN,Kaplan S,Yarar D,Kawut SM,Feldman HI,Christie JD

doi

10.1016/j.jcrc.2012.02.002

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

496-504

issue

5

eissn

0883-9441

issn

1557-8615

pii

S0883-9441(12)00055-X

journal_volume

27

pub_type

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