The interaction of oral hypoglycaemic drugs with insulin on steroid metabolism in hepatocytes isolated from control and diabetic male rats.

Abstract:

:The effects of the oral hypoglycaemic drugs, phenformin and tolbutamide, and insulin, alone and in combination, on steroid metabolism in hepatocytes isolated from control and streptozotocin-diabetic male rats has been studied. Both phenformin and tolbutamide mimic the action of insulin in stimulating hepatic steroid metabolism in a dose-dependent manner in control cells. Unlike insulin, however, both drugs give a similar effect in cells derived from diabetic animals although to a lesser extent. Both drugs can partially restore the effect of insulin in cells derived from diabetic animals. Biguanides and sulphonylureas, therefore, have a direct effect on liver cells to mimic insulin action and can still have an effect under conditions where insulin is inactive. Both types of oral hypoglycaemics can also affect insulin-insensitive cells isolated from diabetic rat liver to restore to a certain extent their response to insulin.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Hussin AH,Skett P

doi

10.1016/0006-2952(90)90724-y

subject

Has Abstract

pub_date

1990-11-15 00:00:00

pages

2285-9

issue

10

eissn

0006-2952

issn

1873-2968

pii

0006-2952(90)90724-Y

journal_volume

40

pub_type

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