The interaction of oral hypoglycaemic drugs with insulin on steroid metabolism in hepatocytes isolated from control and diabetic male rats.

abstract：:Glutathione transferases are believed to play an important protective role in the various tissues of animals and man by catalysing the glutathione conjugation of electrophilic drugs and electrophilic drug metabolites. Many of these compounds have the potential to react with vital cellular macromolecules in the absence...

journal_title：Biochemical pharmacology

authors： Ahokas JT,Davies C,Ravenscroft PJ,Emmerson BT

更新日期：1984-06-15 00:00:00

abstract：:The partition coefficients (Kp) of three prototype Ca2+ antagonists, nitrendipine, (-)-desmethoxyverapamil and flunarizine were determined in native synaptic plasma membranes (SPM) isolated from sheep brain cortex and in liposomes prepared with the total lipids extracted from the membranes. We found that at 25 degrees...

journal_title：Biochemical pharmacology

authors： Carvalho CM,Oliveira CR,Lima MP,Leysen JE,Carvalho AP

更新日期：1989-07-01 00:00:00

abstract：:The antimalarial artemisinin derivatives artesunate (ART), arteether (ARE), and artemether (ARM) reveal remarkable antineoplastic activity. In the present investigation, we identified mRNA expression profiles associated with the response of tumor cells to ART, ARE, and ARM. We performed correlation and hierarchical cl...

journal_title：Biochemical pharmacology

authors： Efferth T,Olbrich A,Bauer R

更新日期：2002-08-15 00:00:00

abstract：:N-[5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl]-L-glutamic acid (ZD1694) is a folate-based thymidylate synthase (TS; EC 2.1.1.45) inhibitor. Metabolism to higher chain length polyglutamates is essential for its optimal cytotoxic effect. A ZD1694-resistant (300-fold) human ileocecal...

journal_title：Biochemical pharmacology

authors： Lu K,Yin MB,McGuire JJ,Bonmassar E,Rustum YM

更新日期：1995-07-31 00:00:00

abstract：:Lactate, once considered a metabolic dead-end, has been recently proposed to support neuron bioenergetics. To better understand how lactate specifically influences cell energy metabolism, we studied the effects of lactate supplementation on SH-SY5Y human neuroblastoma cell bioenergetic fluxes. Lactate supplementation ...

journal_title：Biochemical pharmacology

authors： E L,Swerdlow RH

更新日期：2016-01-01 00:00:00

abstract：:Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous disease processes of the immune system and beyond. CKRs, which belong to the seven transmembrane domain receptor (7TMR) superfamily, initiate signaling upon binding of endogenous...

journal_title：Biochemical pharmacology

authors： Kleist AB,Getschman AE,Ziarek JJ,Nevins AM,Gauthier PA,Chevigné A,Szpakowska M,Volkman BF

更新日期：2016-08-15 00:00:00

abstract：:We have previously reported that Gen-27, a newly synthesized flavonoid, exhibits anticancer effects against human colorectal cancer cells. In this study, we investigated the anticancer effects in human breast cancer cell lines and its underlying mechanisms. We demonstrated that Gen-27 inhibited the growth and prolifer...

journal_title：Biochemical pharmacology

authors： Tao L,Wei L,Liu Y,Ding Y,Liu X,Zhang X,Wang X,Yao Y,Lu J,Wang Q,Hu R

更新日期：2017-02-01 00:00:00

abstract：:The effect of loxoprofen-Na, a novel non-steroidal anti-inflammatory drug with a prodrug property, on prostaglandin (PG) levels in the inflammatory tissue was investigated with a carrageenin-induced pleurisy model in rats. The intrapleural injection of carrageenin caused a marked increase in the levels of PGE2 and 6-k...

journal_title：Biochemical pharmacology

authors： Sugimoto M,Kojima T,Asami M,Iizuka Y,Matsuda K

更新日期：1991-11-27 00:00:00

abstract：:Anti-idiotypic antibodies which recognize the opiate receptor were generated in guinea pigs following immunization against purified rabbit anti-morphine antibodies. The anti-idiotypic antibodies produced a concentration-dependent inhibition of [3H]naloxone binding to opiate receptors in a membranous mouse brain prepar...

journal_title：Biochemical pharmacology

authors： Ng DS,Isom GE

更新日期：1985-08-15 00:00:00

abstract：:Pancreatic cancer is a major cause of cancer-related mortality around the world. Currently, options for diagnosis and treatment are extremely limited, which culminates in a very high mortality rate. Intensive research spanning more than four decades has met several roadblocks in terms of improvement in overall surviva...

journal_title：Biochemical pharmacology

authors： Guha Majumdar A,Subramanian M

更新日期：2019-08-01 00:00:00

abstract：:Pyrazole and several of its derivatives increase the hepatic microsomal coumarin 7-hydroxylase to a variable extent. The strongest inducers are pyrazole itself and those derivatives which have a hydroxy group or a halogen at the 4-position of the molecule. The increase in coumarin 7-hydroxylase is due to an increase i...

journal_title：Biochemical pharmacology

authors： Kojo A,Heiskanen R,Rytkönen AL,Honkakoski P,Juvonen R,Lang M

更新日期：1991-10-09 00:00:00

abstract：:The acute effects of carbon tetrachloride (CCl4) on the membrane structure of rat liver microsomes were studied using 31P-NMR and spin-labeling techniques. 31P-NMR spectra of rat liver microsomes were not changed appreciably after the oral administration of CCl4, indicating that the surface structures of microsomal me...

journal_title：Biochemical pharmacology

authors： Utsumi H,Murayama J,Hamada A

更新日期：1985-01-01 00:00:00

abstract：:A novel enzyme that converts dihydroxyphenylacetic acid (DOPAC) to dihydroxyphenylethanol (DOPET) was found to be present in the microdialysate of the rat brain. The enzyme, named DOPAC reductase, was inhibited by EDTA and stimulated by divalent cations like Zn2+, Mn2+, Co2+ and Cu2+. Its Km, pH optimum and temperatur...

journal_title：Biochemical pharmacology

authors： Xu CL,Sim MK

更新日期：1995-10-26 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs), a family of cytochrome P450 epoxygenase metabolites of arachidonic acid, are believed to have an autocrine or paracrine role in the regulation of neurons or neuroendocrine cells. The effects of 14,15-EET on ionic currents were investigated in rat pituitary GH(3) cells. In the whole-ce...

journal_title：Biochemical pharmacology

authors： Wu SN,Li HF,Chiang HT

更新日期：2000-07-15 00:00:00

abstract：:The Na+/K(+)-pump activity and the utilization of adenosine triphosphate (ATP) were studied in rat peritoneal mast cells after histamine secretion induced by compound 48/80. We measured the ouabain-sensitive K(+)-uptake by a radioactive technique (86Rb+). The ATP content and the glycolytic ATP-production were measured...

journal_title：Biochemical pharmacology

authors： Johansen T,Praetorius H

更新日期：1994-05-18 00:00:00

abstract：:The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice. Cimetidine (400-1000 mg/kg, i.p.) induced dose-dependent tonic convulsion. Muscimol, AOAA and DA...

journal_title：Biochemical pharmacology

authors： Amabeoku GJ,Chikuni O

更新日期：1993-12-14 00:00:00

abstract：:The effects of acute systemic injection of the D-1 agonist SKF 38393 (2.5-20 mg/kg) or the D-1 antagonist SCH 23390 (0.25-2.0 mg/kg), and of the D-2 agonist quinpirole (0.12-1.0 mg/kg) or the D-2 antagonist sulpiride (25-100 mg/kg) on the neuropeptide content of rat basal ganglia were investigated. In striatum, the [M...

journal_title：Biochemical pharmacology

authors： Taylor MD,de Ceballos ML,Jenner P,Marsden CD

更新日期：1991-05-01 00:00:00

abstract：:An intestinal active transport system specific to small peptides and peptide-like drugs such as beta-lactam antibiotics was functionally expressed in Xenopus laevis oocytes after microinjection of messenger RNA (mRNA) derived from rat intestinal mucosal cells. The transport activity was evaluated by measuring the upta...

journal_title：Biochemical pharmacology

authors： Tamai I,Tomizawa N,Kadowaki A,Terasaki T,Nakayama K,Higashida H,Tsuji A

更新日期：1994-08-30 00:00:00

abstract：:Involvement of phosphodiesterase isoenzymes (PDEs) in guanosine-3',5'-cyclic monophosphate (cGMP) hydrolysis was analyzed in aortic smooth muscle cells. Four families of PDEs were separated from pig aorta: PDE1 (calcium-calmodulin-activated), PDE3 (cGMP-inhibited), PDE4 (adenosine 3',5'-cyclic monophosphate [cAMP]-spe...

journal_title：Biochemical pharmacology

authors： Mercapide J,Santiago E,Alberdi E,Martinez-Irujo JJ

更新日期：1999-11-15 00:00:00

abstract：:The existence of a distinct pool of glutathione in the nucleus of cultured human melanoma cells was demonstrated. Melanoma cell nuclei contained 13-35 pmol of glutathione/10(6) nuclei, or approximately 0.4-1.3% of the total cellular glutathione. This nuclear glutathione pool resisted depletion by buthionine sulfoximin...

journal_title：Biochemical pharmacology

authors： Jevtović-Todorović V,Guenthner TM

更新日期：1992-10-06 00:00:00

abstract：:Sulphation in rats, and other mammals, is carried out by a family of sulphotransferase isoenzymes, which can be further subdivided into oestrogen, hydroxysteroid and phenol sulphotransferases. We have examined the effects of hypophysectomy on the activity and expression of representative members of the three major sul...

journal_title：Biochemical pharmacology

authors： Borthwick EB,Voice MW,Burchell A,Coughtrie MW

更新日期：1995-05-17 00:00:00

abstract：:Curcumin (diferuloylmethane) is a well-known agent with anti-inflammatory, antioxidant, and anticarcinogenic properties. In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK. Our in vitro kinase experime...

journal_title：Biochemical pharmacology

authors： Leu TH,Su SL,Chuang YC,Maa MC

更新日期：2003-12-15 00:00:00

abstract：:It has been suggested that vasoactive intestinal polypeptide (VIP) has a role as a neurotransmitter and that it participates in the control of hormone release from thyroid follicles. Many hormones and neurotransmitters alter the ionic permeability properties of the plasma membrane of their target cells when they bind ...

journal_title：Biochemical pharmacology

authors： Green ST

更新日期：1987-12-15 00:00:00

abstract：:Metabolic activation to catechols and their oxidation products is variously considered to contribute to the genotoxic, cytotoxic, transforming and tumour-promoting activities of exogenous steroidal oestrogens. 2-Fluoro-17 alpha-ethynyloestradiol (2-FEE2) was synthesized as a prototype of pharmacologically active deriv...

journal_title：Biochemical pharmacology

authors： Morgan P,Maggs JL,Page PC,Park BK

更新日期：1992-11-03 00:00:00

abstract：:In this study we compared two methods, electron spin resonance (ESR) spectroscopy and high performance liquid chromatography (HPLC), which are currently used to detect directly hydroxyl radical (OH.) formation in the ischemic and reperfused heart. Isolated buffer-perfused rat hearts were subjected to 30 min of normoth...

journal_title：Biochemical pharmacology

authors： Tosaki A,Bagchi D,Pali T,Cordis GA,Das DK

更新日期：1993-02-24 00:00:00

abstract：:Muscarinic receptors of the m2 subtype expressed in Chinese hamster ovary cells were labeled with [methyl-3H]acetylcholine([3H]ACh), and the rate of dissociation in the presence and absence of several compounds known to exert allosteric effects on labeled antagonist binding was observed. At 25 degrees C, [3H]ACh bound...

journal_title：Biochemical pharmacology

authors： Gnagey A,Ellis J

更新日期：1996-12-13 00:00:00

abstract：:HeLa S3 cells exposed to Adriamycin and Daunomycin for 3 hr at EC90 and 10 x EC90 concentrations and incubated in drug-free medium demonstrated the characteristics of apoptosis, morphological changes and fragmentation of DNA into oligonucleosome-sized fragments. The kinetics of DNA degradation after incubation with Ad...

journal_title：Biochemical pharmacology

authors： Skladanowski A,Konopa J

更新日期：1993-08-03 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon where cancer cells become simultaneously resistant to anticancer drugs with different structures and mechanisms of action. MDR has been shown to be associated with overexpression of ATP-binding cassette (ABC) transporters. Here, we report that telatinib, a small molecule tyro...

journal_title：Biochemical pharmacology

authors： Sodani K,Patel A,Anreddy N,Singh S,Yang DH,Kathawala RJ,Kumar P,Talele TT,Chen ZS

更新日期：2014-05-01 00:00:00

abstract：:Nobiletin is a polymethoxylated flavone found in certain citrus fruits that exhibits various pharmacological effects including anti-inflammatory, antitumor and neuroprotective properties. The present study investigated the effects of nobiletin on insulin sensitivity in obese diabetic ob/ob mice, and the possible mecha...

journal_title：Biochemical pharmacology

authors： Lee YS,Cha BY,Saito K,Yamakawa H,Choi SS,Yamaguchi K,Yonezawa T,Teruya T,Nagai K,Woo JT

更新日期：2010-06-01 00:00:00

abstract：:In isolated hepatic nuclei, the heavy metals Zn2+ and Cu2+ (10 microM) inhibited Ca2+ uptake and caused a prompt release of Ca2+ from preloaded nuclei in a concentration-dependent manner, with Zn2+ being more effective than Cu2+. The sulfhydryl group reducing agent dithiothreitol (DTT) protected the nuclei from the ef...

journal_title：Biochemical pharmacology

authors： Yamaguchi M

更新日期：1993-02-24 00:00:00