Anti-morphine anti-idiotypic antibodies. Opiate receptor binding and isolated tissue responses.

Abstract:

:Anti-idiotypic antibodies which recognize the opiate receptor were generated in guinea pigs following immunization against purified rabbit anti-morphine antibodies. The anti-idiotypic antibodies produced a concentration-dependent inhibition of [3H]naloxone binding to opiate receptors in a membranous mouse brain preparation. Saturation analysis indicated that the antibodies produced a non-competitive inhibition of naloxone binding. The ability of the antibodies to interact with biological systems was investigated in in vitro systems. In both the isolated guinea pig ileal longitudinal muscle and mouse vas deferens, the antibodies produced a concentration-dependent, opiate agonist-like action. The anti-morphine anti-idiotypic antibodies appear to interact specifically with the opiate receptor and may serve as useful tools in characterization of this receptor system.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Ng DS,Isom GE

doi

10.1016/0006-2952(85)90006-1

subject

Has Abstract

pub_date

1985-08-15 00:00:00

pages

2853-8

issue

16

eissn

0006-2952

issn

1873-2968

pii

0006-2952(85)90006-1

journal_volume

34

pub_type

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