Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.

abstract：:Exposure of lung tissue to Co(II) ions both in vivo and in vitro results in toxicity, a relatively early event of which is the oxidation of cellular glutathione. In this study we have attempted to delineate the relationship between this oxidation of glutathione and the subsequent development of cellular dysfunction. S...

journal_title：Biochemical pharmacology

authors： Lewis CP,Demedts M,Nemery B

更新日期：1992-02-04 00:00:00

abstract：:Hep G2 cells, an established cell line derived from a human hepatoma, have retained a number of hepatocytic phase I and II reactions. The influence of picolines (2-, 3- and 4-methylpyridine), related compounds and some classical enzyme inducers on specific glutathione transferase (GST) activity and its subunit composi...

journal_title：Biochemical pharmacology

authors： Dierickx PJ

更新日期：1994-11-16 00:00:00

abstract：:After partial hepatectomy (PHx), there are significant changes in the activity of a number of enzymes in the regenerating rat liver. Administration of low doses of recombinant human tumor necrosis factor-alpha (rHu-TNF) to normal rats induces similar changes in some of the enzymes but not in others. Because certain ob...

journal_title：Biochemical pharmacology

authors： Yasmineh WG,Beyer HS,Caspers JI,Theologides A

更新日期：1995-10-12 00:00:00

abstract：:Apo 2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL), is a member of the TNF family of cytokines, which can induce apoptotic cell death in cells expressing at least one of their specific death receptors, DR4 (TRAIL-R1) or DR5 (TRAIL-R2). In the last decade, the Apo2L/TRAIL system of...

journal_title：Biochemical pharmacology

authors： Martinez-Lostao L,Marzo I,Anel A,Naval J

更新日期：2012-06-01 00:00:00

abstract：:The response and engagement of host normal tissues in malignant disease are major factors in therapeutic resistance. Physically, solid tumors have regions of hypoxia and acidosis. These physical stresses can lead to a more aggressive malignant phenotype through activation of HIF, GLUT-1, carbonic anhydrase IX, and sub...

journal_title：Biochemical pharmacology

authors： Teicher BA

更新日期：2009-06-01 00:00:00

abstract：:When INH was administered orally or intraperitoneally to pregnant female mice, the concentrations of acetyl INH and acetyl hydrazines did not vary significantly in circulating blood and in amniotic fluid. However, the concentration of INH in the amniotic fluid was significantly higher than that observed in the serum. ...

journal_title：Biochemical pharmacology

authors： Menon MM,Bhide SV

更新日期：1983-02-15 00:00:00

abstract：:The antiinflammatory effect of superoxide dismutase was studied in rats with kidney intoxication induced by the injection of nephrotoxic serum. The urinary excretion of protein was increased significantly by the administration of an intravenous injection of nephrotoxic serum. The daily injection of superoxide dismutas...

journal_title：Biochemical pharmacology

authors： Adachi T,Fukuta M,Ito Y,Hirano K,Sugiura M,Sugiura K

更新日期：1986-01-15 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are members of a class of ancient, highly conserved signalling molecules that play major roles in embryonic axis determination, organ development, tissue repair, and regeneration throughout the animal kingdom. The bone morphogenetic proteins are potent developmental morphogens that a...

journal_title：Biochemical pharmacology

authors： Kaplan FS,Shore EM

更新日期：1998-02-15 00:00:00

abstract：:A structure-activity study of fourteen chemically related flavonoids was conducted to evaluate their abilities to inhibit glutathione reductase (GR). By comparing the I50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibit...

journal_title：Biochemical pharmacology

authors： Elliott AJ,Scheiber SA,Thomas C,Pardini RS

更新日期：1992-10-20 00:00:00

abstract：:Amodiaquine, a 4-aminoquinoline antimalarial, has been associated with hepatitis and agranulocytosis in humans. Drug hypersensitivity reactions, especially agranulocytosis, have been attributed to reactive intermediates generated by the oxidants discharged from stimulated polymorphonuclear leucocytes (PMN). The metabo...

journal_title：Biochemical pharmacology

authors： Tingle MD,Jewell H,Maggs JL,O'Neill PM,Park BK

更新日期：1995-09-28 00:00:00

abstract：:Reduced glutathione is nitrosated in aerobic solutions of nitric oxide under physiological conditions; however, the extent of S-nitrosation was found to be dependent on the inorganic anions present. Of nine anions tested, the bifunctional anions, arsenate, phosphate, and pyrophosphate (40 mM), inhibited the S-nitrosat...

journal_title：Biochemical pharmacology

authors： DeMaster EG,Quast BJ,Mitchell RA

更新日期：1997-02-21 00:00:00

abstract：:5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is a commonly used pharmacological agent to study physiological effects which are similar to those of exercise. However, signal transduction pathways by which AICAR elicits downstream effects in liver are poorly understood. We report here that AICAR not on...

journal_title：Biochemical pharmacology

authors： Wang HM,Mehta S,Bansode R,Huang W,Mehta KD

更新日期：2008-01-15 00:00:00

abstract：:The binding of 1,1-dichloroethane (1,1-DCE) to the substrate binding site of hepatic microsomal cytochrome P-450, and the stimulation of hepatic microsomal CO-inhibitable NADPH oxidation by 1,1-DCE and 1,2-dichloroethane (1,2-DCE) were enhanced by induction with phenobarbital but not with beta-naphthoflavone. Incubati...

journal_title：Biochemical pharmacology

authors： McCall SN,Jurgens P,Ivanetich KM

更新日期：1983-01-15 00:00:00

abstract：:N-Acylurea derivatives of albumin and transferrin prepared with the water-soluble carbodiimides N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide and N-ethyl-N'-(3-trimethylpropylammonium)carbodiimide iodide have been found to bind different types of DNA. The two proteins were reacted with varying amounts of carbodiimide...

journal_title：Biochemical pharmacology

authors： Huckett B,Gordhan H,Hawtrey R,Moodley N,Ariatti M,Hawtrey A

更新日期：1986-04-15 00:00:00

abstract：:A series of fucoidan [sulfated poly(L-fucopyranose)] derivatives were prepared by chemical sulfation and desulfation, and they were tested for their abilities to stimulate tissue plasminogen activator (t-PA)-catalyzed plasminogen activation, clot lysis, and the inhibition of fibrin polymer formation. The magnitude of ...

journal_title：Biochemical pharmacology

authors： Soeda S,Sakaguchi S,Shimeno H,Nagamatsu A

更新日期：1992-04-15 00:00:00

abstract：:The homomeric α7 nicotinic acetylcholine receptor is a well-studied therapeutic target, though its characteristically rapid desensitization complicates the development of drugs with specific agonist effects. Moreover, some experimental compounds such as GTS-21 (2,4diMeOBA), a derivative of the α7-selective partial ago...

journal_title：Biochemical pharmacology

authors： Isaacson MD,Horenstein NA,Stokes C,Kem WR,Papke RL

更新日期：2013-03-15 00:00:00

abstract：:The advent of drugs targeting tumor-associated prosurvival alterations of cancer cells has changed the interest of antitumor drug development from cytotoxic drugs to target-specific agents. Although single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, a promising str...

journal_title：Biochemical pharmacology

authors： Perego P,Cossa G,Zuco V,Zunino F

更新日期：2010-11-15 00:00:00

abstract：:ABT-263 induces MCL1 upregulation in cancer cells, which confers resistance to the drug. An increased understanding of the mechanism underlying ABT-263-induced MCL1 expression may provide a strategy to improve its tumor-suppression activity. The present study revealed that ABT-263 reduced the turnover of MCL1 mRNA, th...

journal_title：Biochemical pharmacology

authors： Lee YC,Wang LJ,Huang CH,Chiou JT,Shi YJ,Chang LS

更新日期：2020-08-01 00:00:00

abstract：:Treatment of immature 21-day-old female Sprague-Dawley rats with 17 beta-estradiol (E2) (0.5 microgram/rat) caused a significant increase in uterine wet weight, DNA synthesis, progesterone receptor (PR) binding, and peroxidase activity. At doses as high as 40 mg/rat, the bioflavonoid naringenin did not cause a signifi...

journal_title：Biochemical pharmacology

authors： Ruh MF,Zacharewski T,Connor K,Howell J,Chen I,Safe S

更新日期：1995-10-26 00:00:00

abstract：:The GABA(B) receptor was the first heteromeric G-protein coupled receptor (GPCR) identified. Indeed, both GABA(B1) and GABA(B2) subunits appear necessary to get a functional GABA(B) receptor. Soon after the cloning of both subunits, it was demonstrated that GABA(B2) was required for GABA(B1) to reach the cell surface....

journal_title：Biochemical pharmacology

authors： Pin JP,Kniazeff J,Binet V,Liu J,Maurel D,Galvez T,Duthey B,Havlickova M,Blahos J,Prézeau L,Rondard P

更新日期：2004-10-15 00:00:00

abstract：:Daily subcutaneous administration of the oral hypoglycaemic agent, diphenyleneiodonium at a low dose (1.5 mg/kg body weight) over a 4-5 week period resulted in a normoglycaemic stable animal model of impaired oxidative phosphorylation in the rat. Diphenyleneiodonium specifically inhibits NAD-linked mitochondrial oxida...

journal_title：Biochemical pharmacology

authors： Cooper JM,Petty RK,Hayes DJ,Morgan-Hughes JA,Clark JB

更新日期：1988-02-15 00:00:00

abstract：:We recently found that simvastatin can modulate the nuclear factor-kappaB (NF-kappaB) activation pathway, but whether other statins have similar effects to those of simvastatin is unknown. Therefore, we evaluated the effect six different statins on TNF-induced NF-kappaB activation in human myeloid leukemia cells. We t...

journal_title：Biochemical pharmacology

authors： Ahn KS,Sethi G,Aggarwal BB

更新日期：2008-02-15 00:00:00

abstract：:The beta-adrenergic stimulation of adenylate cyclase in membranes from human lung was compared to that of adenylate cyclase in membranes with a majority of beta 2-adrenergic receptors (from rat lung) and in membranes with a homogeneous population of beta 2-adrenergic receptors (from rat erythrocytes and reticulocytes)...

journal_title：Biochemical pharmacology

authors： Delhaye M,Taton G,Camus JC,Chatelain P,Robberecht P,Waelbroeck M,Christophe J

更新日期：1983-06-15 00:00:00

abstract：:Short-term agonist-induced loss of cell surface muscarinic receptors and desensitization of receptor-mediated cyclic GMP (cGMP) formation and phosphoinositide hydrolysis were examined in mouse neuroblastoma cells (clone N1E-115) in suspension. This treatment resulted in a time-dependent reduction of approximately 40% ...

journal_title：Biochemical pharmacology

authors： Cioffi CL,el-Fakahany EE

更新日期：1989-06-01 00:00:00

abstract：:MOLT-4 (T-), RAJI (B-), and KM-3 (non-B-non-T-, common ALL) malignant lymphoblasts demonstrated significant differences in their activities of purine de novo synthesis (PDNS) and purine salvage pathway and in their cell-kinetic parameters. Incubations with concentrations of methotrexate (0.02 and 0.2 microM), which ca...

journal_title：Biochemical pharmacology

authors： Bökkerink JP,De Abreu RA,Bakker MA,Hulscher TW,van Baal JM,Schretlen ED,De Bruijn CH

更新日期：1988-06-15 00:00:00

abstract：:The peripheral benzodiazepine receptor (PBR), an integral protein of the mitochondrial membrane, is involved in the formation of mitochondrial permeability transition (MPT) pores. The opening of the MPT-leading to the dissipation of the inner-mitochondrial transmembrane potential (deltapsi(m))-is considered to be an e...

journal_title：Biochemical pharmacology

authors： Strohmeier R,Roller M,Sänger N,Knecht R,Kuhl H

更新日期：2002-07-01 00:00:00

abstract：:These in vitro studies indicate that N-oxidation of N-hydroxyamphetamine (NOHA) by rat liver homogenates yields phenylacetone oxime (PAOx) as the major metabolite. This oxidation was NADPH and oxygen dependent but was not appreciably increased in microsomes from phenobarbital-pretreated animals. The addition to micros...

journal_title：Biochemical pharmacology

authors： Matsumoto RM,Cho AK

更新日期：1982-01-01 00:00:00

abstract：:The recombinant plasmid pBHIV1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants resistant to geneticin expressed CAT activity from the HIV-1 LTR. It was...

journal_title：Biochemical pharmacology

authors： Zoumpourlis V,Kerr DJ,Spandidos DA

更新日期：1992-02-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death. Different signaling pathways are de-regulated in this pathogenesis, among them the epidermal growth factor receptor one (EGFR/Erb1). Here we show that blockage of this pathway by the tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyqui...

journal_title：Biochemical pharmacology

authors： Caja L,Sancho P,Bertran E,Ortiz C,Campbell JS,Fausto N,Fabregat I

更新日期：2011-12-01 00:00:00

abstract：:Quantitative RNase protection assays were performed to determine the levels of muscarinic receptor subtype (m1-m5) mRNAs in rat hippocampi. Results showed that the m1, m3, and m4 subtype mRNAs were expressed at relatively high levels, but the levels of the m2 and m5 subtype were very low. Three weeks following aspirat...

journal_title：Biochemical pharmacology

authors： Zang Z,Creese I

更新日期：1997-05-09 00:00:00