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Carboplatin as opposed to cisplatin does not stimulate the expression of the human immunodeficiency virus long terminal repeat sequences.

Abstract：

:The recombinant plasmid pBHIV1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants resistant to geneticin expressed CAT activity from the HIV-1 LTR. It was found that the cytotoxic drug cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) (carboplatin) at concentrations from 1 x 10(-6) to 1 x 10(-4) M does not stimulate the expression of CAT from the HIV-1 LTR. These results differ from previous studies with the related drug cis-diamminedichloroplatinum(II) which showed stimulation of gene expression from the HIV-1 LTR and suggest that carboplatin could be used in the treatment of cancer patients with Acquired Immune Deficiency Syndrome.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Zoumpourlis V,Kerr DJ,Spandidos DA

doi

10.1016/0006-2952(92)90592-7

subject

Has Abstract

pub_date

1992-02-04 00:00:00

pages

650-4

issue

3

eissn

0006-2952

issn

1873-2968

pii

0006-2952(92)90592-7

journal_volume

43

pub_type

杂志文章

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