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Cardiac sensitivity to the inhibitory effects of chlorpromazine, imipramine and amitriptyline upon formation of flavins.

Abstract：

:Chlorpromazine, imipramine and amitriptyline, drugs structurally related to riboflavin, each inhibited the formation in vivo of flavin adenine dinucleotide (FAD) from riboflavin in rat heart at 2-5 mg/kg body weight, doses comparable on a weight basis to those used clinically. All three drugs inhibited FAD formation in heart within 5 hr after a single dose of 25 mg/kg. Chlorpromazine under these conditions also inhibited FAD formation in liver, cerebrum and cerebellum. A series of psychoactive agents structurally unrelated to riboflavin did not inhibit flavin formation in the organs tested. These findings indicate that the inhibitory effects of the drugs studied have organ specificity with respect to FAD formation.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Pinto J,Huang YP,Pelliccione N,Rivlin RS

doi

10.1016/0006-2952(82)90632-3

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

3495-9

issue

21

eissn

0006-2952

issn

1873-2968

pii

0006-2952(82)90632-3

journal_volume

31

pub_type

杂志文章

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